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The map label for this gene is sdaA [H]

Identifier: 218709792

GI number: 218709792

Start: 1933371

End: 1934732

Strand: Direct

Name: sdaA [H]

Synonym: VS_1804

Alternate gene names: 218709792

Gene position: 1933371-1934732 (Clockwise)

Preceding gene: 218709791

Following gene: 218709795

Centisome position: 58.6

GC content: 46.18

Gene sequence:

>1362_bases
ATGATTAGTGTATTTGATATCTATAAAATCGGTGTTGGTCCATCGAGCTCACATACAGTTGGACCAATGAAAGCGGGTAA
AGAATTTATTGATGACCTACGTTCAATGGGAAAATTGCGCGACATCACTAAAATCACCGTGGACGTATATGGATCACTAT
CACTGACAGGGAAAGGTCACCACACAGATATCGCAATCATCATGGGTCTTGCTGGCAATACTCCTGAGCGTGTTGATATC
GATTCTATTGCAGGCTTCATTGCTCGAGTAGAAGAAACTGAACGTCTACCTGTCGGTATGCACTGTCATACTGTTTCGTT
CCCTCGCGACGGCGGAATGAACTTCCACACTAGCAACCTTTCTCTACACGAGAATGGCATGAGCATTCATGCTTGGGTTG
ATGACGAAGTCGCATATTCAAAAACGTATTACTCAATTGGTGGTGGTTTCATCGTTGACGAAGAGAACTTCGGCAAAGAA
GAAGAAAACCCAATTAAAGCACCTTACGAATTCACAACAGCGGAAGAGCTGGTTAATCAGTGTAAAGAAAGTGGTCTTTC
TATCAGTACACTGGTTATGAAAAACCAAGCGGCTTTCCACTCAGACGAAGAGTCTCGCACTTACTTCGCTAACATCTGGA
AAACGATGCGTGAGTGTATGGATCGCGGTATGAATACTGAAGGTATCCTGCCTGGTCCACTGCGTGTACCTCGTCGTGCA
GCAGCACTTCGCCAACAGCTGATCACTTCAGAAAAAACAACTAACGATCCAATGACGGTTGTTGACTGGGTGAACATGTT
TGCTTTCGCAGTAAACGAAGAAAACGCAGCGGGCGGTCGTGTAGTAACGGCACCAACAAACGGCGCGTGTGGCATCATCC
CTGCTGTATTGGCTTACTACGATAAGTTCATTCAAACAGTGACAGAGAAAGACTACATCCGTTACTTCGCAGCTTCTGGC
GCGATCGGGGGTCTTTACAAGCGTAACGCTTCTATCTCTGGTGCTGAAGTTGGCTGTCAGGGTGAAGTTGGCGTGGCGTG
TTCTATGGCTGCTGCTGGTCTTGCTGAGCTTATGGGTGGTAGCCCAGAGCAAGTATGTATGGCTGCAGAAATCGGCATGG
AACACAACCTAGGTCTAACGTGTGACCCAGTTGCTGGCCAAGTACAAGTTCCATGTATTGAGCGTAACGGTATTGCTGCA
GTTAAAGCAATCAACTCAACTCGTATGGCACTTCGTCGCTCTTCTGCCCCTACTGTTTCTCTAGATAAAGTTATCGAAAC
AATGCTAGAAACCGGTAAAGACATGAACGCTAAATACCGTGAGACTTCTCAAGGTGGTTTGGCAGTTAAGGTGGTTTGTT
AA

Upstream 100 bases:

>100_bases
ATGACATTCATCTTATATGGCGAGGTTAGACAAAAAATATAATGATAATAAATGAGCCTCCCTACTCCCCTTGGGAGGCT
CTCTTTTTGAGGTAATCGCT

Downstream 100 bases:

>100_bases
TTAGCATTAGTTTGTTAATAGTTTTCGAATCAATTTGCTTTTAATGAGCAGATAATAAAAAGGAACGCCGATGCGTTCCT
TTTTTTGTATCTGAATTCCG

Product: L-serine dehydratase 1

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRSMGKLRDITKITVDVYGSLSLTGKGHHTDIAIIMGLAGNTPERVDI
DSIAGFIARVEETERLPVGMHCHTVSFPRDGGMNFHTSNLSLHENGMSIHAWVDDEVAYSKTYYSIGGGFIVDEENFGKE
EENPIKAPYEFTTAEELVNQCKESGLSISTLVMKNQAAFHSDEESRTYFANIWKTMRECMDRGMNTEGILPGPLRVPRRA
AALRQQLITSEKTTNDPMTVVDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIQTVTEKDYIRYFAASG
AIGGLYKRNASISGAEVGCQGEVGVACSMAAAGLAELMGGSPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIAA
VKAINSTRMALRRSSAPTVSLDKVIETMLETGKDMNAKYRETSQGGLAVKVVC

Sequences:

>Translated_453_residues
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRSMGKLRDITKITVDVYGSLSLTGKGHHTDIAIIMGLAGNTPERVDI
DSIAGFIARVEETERLPVGMHCHTVSFPRDGGMNFHTSNLSLHENGMSIHAWVDDEVAYSKTYYSIGGGFIVDEENFGKE
EENPIKAPYEFTTAEELVNQCKESGLSISTLVMKNQAAFHSDEESRTYFANIWKTMRECMDRGMNTEGILPGPLRVPRRA
AALRQQLITSEKTTNDPMTVVDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIQTVTEKDYIRYFAASG
AIGGLYKRNASISGAEVGCQGEVGVACSMAAAGLAELMGGSPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIAA
VKAINSTRMALRRSSAPTVSLDKVIETMLETGKDMNAKYRETSQGGLAVKVVC
>Mature_453_residues
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRSMGKLRDITKITVDVYGSLSLTGKGHHTDIAIIMGLAGNTPERVDI
DSIAGFIARVEETERLPVGMHCHTVSFPRDGGMNFHTSNLSLHENGMSIHAWVDDEVAYSKTYYSIGGGFIVDEENFGKE
EENPIKAPYEFTTAEELVNQCKESGLSISTLVMKNQAAFHSDEESRTYFANIWKTMRECMDRGMNTEGILPGPLRVPRRA
AALRQQLITSEKTTNDPMTVVDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYYDKFIQTVTEKDYIRYFAASG
AIGGLYKRNASISGAEVGCQGEVGVACSMAAAGLAELMGGSPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIAA
VKAINSTRMALRRSSAPTVSLDKVIETMLETGKDMNAKYRETSQGGLAVKVVC

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=453, Percent_Identity=74.39293598234, Blast_Score=719, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=452, Percent_Identity=71.0176991150443, Blast_Score=678, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=453, Percent_Identity=67.7704194260486, Blast_Score=635, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48896; Mature: 48896

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRSMGKLRDITKITVDVYGSLSLTGKGH
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCC
HTDIAIIMGLAGNTPERVDIDSIAGFIARVEETERLPVGMHCHTVSFPRDGGMNFHTSNL
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCC
SLHENGMSIHAWVDDEVAYSKTYYSIGGGFIVDEENFGKEEENPIKAPYEFTTAEELVNQ
EEECCCCEEEEEECCCHHHCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHH
CKESGLSISTLVMKNQAAFHSDEESRTYFANIWKTMRECMDRGMNTEGILPGPLRVPRRA
HHHCCCEEEEEEEECCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AALRQQLITSEKTTNDPMTVVDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYY
HHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DKFIQTVTEKDYIRYFAASGAIGGLYKRNASISGAEVGCQGEVGVACSMAAAGLAELMGG
HHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIAAVKAINSTRMALRRSSAPTVS
CHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEECCCCCEEEEEHHHHHHHHHCCCCCCEE
LDKVIETMLETGKDMNAKYRETSQGGLAVKVVC
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MISVFDIYKIGVGPSSSHTVGPMKAGKEFIDDLRSMGKLRDITKITVDVYGSLSLTGKGH
CCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEEECCCCC
HTDIAIIMGLAGNTPERVDIDSIAGFIARVEETERLPVGMHCHTVSFPRDGGMNFHTSNL
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCC
SLHENGMSIHAWVDDEVAYSKTYYSIGGGFIVDEENFGKEEENPIKAPYEFTTAEELVNQ
EEECCCCEEEEEECCCHHHCEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHH
CKESGLSISTLVMKNQAAFHSDEESRTYFANIWKTMRECMDRGMNTEGILPGPLRVPRRA
HHHCCCEEEEEEEECCHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
AALRQQLITSEKTTNDPMTVVDWVNMFAFAVNEENAAGGRVVTAPTNGACGIIPAVLAYY
HHHHHHHHHCCCCCCCCHHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DKFIQTVTEKDYIRYFAASGAIGGLYKRNASISGAEVGCQGEVGVACSMAAAGLAELMGG
HHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCMAAEIGMEHNLGLTCDPVAGQVQVPCIERNGIAAVKAINSTRMALRRSSAPTVS
CHHHHHHHHHCCCCCCCCEEECCCCCCEEEEEECCCCCEEEEEHHHHHHHHHCCCCCCEE
LDKVIETMLETGKDMNAKYRETSQGGLAVKVVC
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]