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The map label for this gene is macA [H]

Identifier: 218709530

GI number: 218709530

Start: 1676472

End: 1677605

Strand: Direct

Name: macA [H]

Synonym: VS_1539

Alternate gene names: 218709530

Gene position: 1676472-1677605 (Clockwise)

Preceding gene: 218709529

Following gene: 218709531

Centisome position: 50.81

GC content: 44.18

Gene sequence:

>1134_bases
ATGAAGCCTATCTTTCAACATTCATCTATTTTTCAACGTTCGTCTACCTTTCAACAGACACCTATATTCAAATATACAGT
CATTGCACTAAGCTTAACCGCCCTGTTTGGCTGTAATGACTCTGAGGCGACTGCACCTCAAAAACAAGCTCGACCAATTC
AAGTGATTCAACTTGAGCCTCTTTCACACAAGGCTGAAAAATCTTTTACTGGCAAGATACAATCATCGGAAACGGCTGGC
GTTGCGTTTCGTGTGCCTGGCACTATTCAAAATATGATGGTCTCTGTTGGTGATTCAGTAAAAAAAGGGCAACCACTTGC
GCAGTTAGACCCTCATGACTATCAAGTCGCGTTAGAAGAGTTACAAGCACGAGCCCTTGAAGCTAAATCTGCACACAAAT
TGGCGACATCCGAACTTGTACGCGTAAAACAAGCCATCGCTGATAATGCGATTGCCGATGTTAACCTAGACCGTGCTATT
AGCGGGTACGAGCGAAGTGAAGCGGCGGTTAAAGTCGTAGAACAGAATATACGCCGTGCGAAAGATTCGATTCGTTATAC
CCAATTGCTCGCCCCTTTCGATGGTGTGGTTGCGGCATCCAATTTTGACCAGTACGAACAAGTAATGCCGGGCATCTCGG
TGTTCACAATCCACAATCCAGATAAACTTGAAGTTAAAATTCAAGTACCTGAAAATTTGATTCATGAGTTCAAACCAAAT
CAAAGTTCTGTCATAGATTGGTATGGTTCAGAGACTAAACTAATTGGTTATGCCGCTGAAATTTCGACGTCACCTCACCC
TATCAAGCAGACCTATGCGGTTACTTACCATGTCGACTCCACTGACAAATCGGTATTGCCTGGAAAAGCGGTCACATTGA
CGACTCAACTTGGAGAAGCGAGCAGTAATTTCTGTTTGCCCTATTCTGCGTTAGTCAACCAAACGGGTATCGAGCAAGTA
TTCACGGTTAAAAATGAACAAGCTCATGGCGTGACTGTGGATGTGATTTCTATGTCCGAAAATACTGTGTGTGTTGAATC
GACGCTCAATGATGGCGACTTCGTGGTCGTGAGTGGCGCGCAATACGTGGTGGAAGGACAGTACTTCTCCAATATTCAAG
TTAAAAGCCTGTAG

Upstream 100 bases:

>100_bases
CCATTGTAATGAATATTGTGACAGTGTTTCACGAGCAGGCTAGATTATCCTAACGAAATAGAAAGATAGAATCGCTTCAT
AAATTCAAGAGGAGCAATCC

Downstream 100 bases:

>100_bases
GTGAACCATGATGAATCTAGCTGATTTTGCAATCAAACAACGCACCTTCATCCTGTTTTTCACTGCACTGAGTGTCATCG
CAGGCCTGTTTTCTTATTTT

Product: putative efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKPIFQHSSIFQRSSTFQQTPIFKYTVIALSLTALFGCNDSEATAPQKQARPIQVIQLEPLSHKAEKSFTGKIQSSETAG
VAFRVPGTIQNMMVSVGDSVKKGQPLAQLDPHDYQVALEELQARALEAKSAHKLATSELVRVKQAIADNAIADVNLDRAI
SGYERSEAAVKVVEQNIRRAKDSIRYTQLLAPFDGVVAASNFDQYEQVMPGISVFTIHNPDKLEVKIQVPENLIHEFKPN
QSSVIDWYGSETKLIGYAAEISTSPHPIKQTYAVTYHVDSTDKSVLPGKAVTLTTQLGEASSNFCLPYSALVNQTGIEQV
FTVKNEQAHGVTVDVISMSENTVCVESTLNDGDFVVVSGAQYVVEGQYFSNIQVKSL

Sequences:

>Translated_377_residues
MKPIFQHSSIFQRSSTFQQTPIFKYTVIALSLTALFGCNDSEATAPQKQARPIQVIQLEPLSHKAEKSFTGKIQSSETAG
VAFRVPGTIQNMMVSVGDSVKKGQPLAQLDPHDYQVALEELQARALEAKSAHKLATSELVRVKQAIADNAIADVNLDRAI
SGYERSEAAVKVVEQNIRRAKDSIRYTQLLAPFDGVVAASNFDQYEQVMPGISVFTIHNPDKLEVKIQVPENLIHEFKPN
QSSVIDWYGSETKLIGYAAEISTSPHPIKQTYAVTYHVDSTDKSVLPGKAVTLTTQLGEASSNFCLPYSALVNQTGIEQV
FTVKNEQAHGVTVDVISMSENTVCVESTLNDGDFVVVSGAQYVVEGQYFSNIQVKSL
>Mature_377_residues
MKPIFQHSSIFQRSSTFQQTPIFKYTVIALSLTALFGCNDSEATAPQKQARPIQVIQLEPLSHKAEKSFTGKIQSSETAG
VAFRVPGTIQNMMVSVGDSVKKGQPLAQLDPHDYQVALEELQARALEAKSAHKLATSELVRVKQAIADNAIADVNLDRAI
SGYERSEAAVKVVEQNIRRAKDSIRYTQLLAPFDGVVAASNFDQYEQVMPGISVFTIHNPDKLEVKIQVPENLIHEFKPN
QSSVIDWYGSETKLIGYAAEISTSPHPIKQTYAVTYHVDSTDKSVLPGKAVTLTTQLGEASSNFCLPYSALVNQTGIEQV
FTVKNEQAHGVTVDVISMSENTVCVESTLNDGDFVVVSGAQYVVEGQYFSNIQVKSL

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=314, Percent_Identity=23.8853503184713, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI87082036, Length=378, Percent_Identity=23.5449735449735, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41285; Mature: 41285

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIFQHSSIFQRSSTFQQTPIFKYTVIALSLTALFGCNDSEATAPQKQARPIQVIQLEP
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEECC
LSHKAEKSFTGKIQSSETAGVAFRVPGTIQNMMVSVGDSVKKGQPLAQLDPHDYQVALEE
CCCCHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHH
LQARALEAKSAHKLATSELVRVKQAIADNAIADVNLDRAISGYERSEAAVKVVEQNIRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHCCCHHHHHHHHHHHHHHHHH
KDSIRYTQLLAPFDGVVAASNFDQYEQVMPGISVFTIHNPDKLEVKIQVPENLIHEFKPN
HHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCEEEEEECCCEEEEEEECCHHHHHHCCCC
QSSVIDWYGSETKLIGYAAEISTSPHPIKQTYAVTYHVDSTDKSVLPGKAVTLTTQLGEA
CCCEEEECCCCEEEEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEEECCCC
SSNFCLPYSALVNQTGIEQVFTVKNEQAHGVTVDVISMSENTVCVESTLNDGDFVVVSGA
CCCCEECHHHHHCCCCCHHEEEECCCCCCCEEEEEEEECCCEEEEEECCCCCCEEEECCC
QYVVEGQYFSNIQVKSL
EEEEECCEECCEEEEEC
>Mature Secondary Structure
MKPIFQHSSIFQRSSTFQQTPIFKYTVIALSLTALFGCNDSEATAPQKQARPIQVIQLEP
CCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEEECC
LSHKAEKSFTGKIQSSETAGVAFRVPGTIQNMMVSVGDSVKKGQPLAQLDPHDYQVALEE
CCCCHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHHCCCHHCCCCCCCCCCCHHHHHHHH
LQARALEAKSAHKLATSELVRVKQAIADNAIADVNLDRAISGYERSEAAVKVVEQNIRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHCCCHHHHHHHHHHHHHHHHH
KDSIRYTQLLAPFDGVVAASNFDQYEQVMPGISVFTIHNPDKLEVKIQVPENLIHEFKPN
HHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCEEEEEECCCEEEEEEECCHHHHHHCCCC
QSSVIDWYGSETKLIGYAAEISTSPHPIKQTYAVTYHVDSTDKSVLPGKAVTLTTQLGEA
CCCEEEECCCCEEEEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCEEEEEEECCCC
SSNFCLPYSALVNQTGIEQVFTVKNEQAHGVTVDVISMSENTVCVESTLNDGDFVVVSGA
CCCCEECHHHHHCCCCCHHEEEECCCCCCCEEEEEEEECCCEEEEEECCCCCCEEEECCC
QYVVEGQYFSNIQVKSL
EEEEECCEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]