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The map label for this gene is ttcA [H]

Identifier: 218709460

GI number: 218709460

Start: 1601811

End: 1602716

Strand: Reverse

Name: ttcA [H]

Synonym: VS_1469

Alternate gene names: 218709460

Gene position: 1602716-1601811 (Counterclockwise)

Preceding gene: 218709461

Following gene: 218709449

Centisome position: 48.58

GC content: 42.38

Gene sequence:

>906_bases
GTGAGAGTCGCAATGAACCAAAACGAAAATAAAAAAGAAACACTTGAATTCAACAAGCTTCAGAAACGTCTGAGACGAAA
TGTTGGAAATGCCATCGTTGACTACAACATGATCGAAGAGAATGACGTAGTAATGGCATGCATTAGTGGCGGTAAAGATT
CATTTGCGATGCTAGATATTTTGCTACGTTTACGTGAAGCTGCACCTATCAAATTCGATGTTGTTGCCGTAAACCTAGAC
CAAAAACAACCTGGCTTTCCTGAACATATTCTTCCTGAGTACTTCGAAACTCTGAACATTCCTTACTACATCGTAGATAA
AGATACGTACTCCGTAGTTAAAGAGAAAGTGCCAGAGGGTAAAACAACCTGTGGTCTATGTTCTCGTCTTCGTCGTGGTA
CTTTGTACTCGTTTGCAGAGAAAATTGGGGCGACTAAGATTGCTCTTGGCCACCACCTAGACGATATTGTTGAGACGATG
TTCCTGAACATGTTCCACGGTGCACGCTTGAAAGCAATGCCGCCAAAATTGCGTTCTGATGATGGCCGTAACGTTGTTAT
TCGTCCACTGACTTATTGTCGTGAAACGGACTTAATCCAATACGCAGAGCACCTAGATTTCCCAATCATTCCTTGTAACC
TGTGTGGCTCTCAAGAGAACCTACAGCGTCAGAACATTAAAGCGATGTTGATTGATTGGGATAAGCAAACGCCAGGTCGT
GTTGAGAAGATTTTCAAGTCAATTCAGAACGTAAGTCCAAGCCAACTGGCTGACCGAGAACTGTTTGATTTCGTAAACCT
TCCACTAGACCGTAGTGAAGATCGCAAGGCCTACGAATTCGAAGAAGCTGAAATTTCCTCTTCAAATATTGATGAGTCAA
TGTTCATCGACGTGACTAACGTATAA

Upstream 100 bases:

>100_bases
TGTTAATCCTGCCGTTACTATTTCAACATCAAATAAAAATCCGTATAATCCACGCCCTAAAACAGTCCCACTAGCAATCT
ACAGTCGGTAATACGACGGT

Downstream 100 bases:

>100_bases
TACCAATCGTAGTAAATAACTGTTCATCCTAGCTGGTTAAAACACTCGATAACATCGTTAGAAATTTTGATTGTAGAATA
ACTACTTATCGAAAATTTCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MRVAMNQNENKKETLEFNKLQKRLRRNVGNAIVDYNMIEENDVVMACISGGKDSFAMLDILLRLREAAPIKFDVVAVNLD
QKQPGFPEHILPEYFETLNIPYYIVDKDTYSVVKEKVPEGKTTCGLCSRLRRGTLYSFAEKIGATKIALGHHLDDIVETM
FLNMFHGARLKAMPPKLRSDDGRNVVIRPLTYCRETDLIQYAEHLDFPIIPCNLCGSQENLQRQNIKAMLIDWDKQTPGR
VEKIFKSIQNVSPSQLADRELFDFVNLPLDRSEDRKAYEFEEAEISSSNIDESMFIDVTNV

Sequences:

>Translated_301_residues
MRVAMNQNENKKETLEFNKLQKRLRRNVGNAIVDYNMIEENDVVMACISGGKDSFAMLDILLRLREAAPIKFDVVAVNLD
QKQPGFPEHILPEYFETLNIPYYIVDKDTYSVVKEKVPEGKTTCGLCSRLRRGTLYSFAEKIGATKIALGHHLDDIVETM
FLNMFHGARLKAMPPKLRSDDGRNVVIRPLTYCRETDLIQYAEHLDFPIIPCNLCGSQENLQRQNIKAMLIDWDKQTPGR
VEKIFKSIQNVSPSQLADRELFDFVNLPLDRSEDRKAYEFEEAEISSSNIDESMFIDVTNV
>Mature_301_residues
MRVAMNQNENKKETLEFNKLQKRLRRNVGNAIVDYNMIEENDVVMACISGGKDSFAMLDILLRLREAAPIKFDVVAVNLD
QKQPGFPEHILPEYFETLNIPYYIVDKDTYSVVKEKVPEGKTTCGLCSRLRRGTLYSFAEKIGATKIALGHHLDDIVETM
FLNMFHGARLKAMPPKLRSDDGRNVVIRPLTYCRETDLIQYAEHLDFPIIPCNLCGSQENLQRQNIKAMLIDWDKQTPGR
VEKIFKSIQNVSPSQLADRELFDFVNLPLDRSEDRKAYEFEEAEISSSNIDESMFIDVTNV

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=259, Percent_Identity=66.4092664092664, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI193211090, Length=256, Percent_Identity=31.25, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17540090, Length=240, Percent_Identity=27.5, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24651972, Length=231, Percent_Identity=25.974025974026, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 34559; Mature: 34559

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAMNQNENKKETLEFNKLQKRLRRNVGNAIVDYNMIEENDVVMACISGGKDSFAMLDI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECEEECCCCEEEEEECCCCCHHHHHHH
LLRLREAAPIKFDVVAVNLDQKQPGFPEHILPEYFETLNIPYYIVDKDTYSVVKEKVPEG
HHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCC
KTTCGLCSRLRRGTLYSFAEKIGATKIALGHHLDDIVETMFLNMFHGARLKAMPPKLRSD
CCHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DGRNVVIRPLTYCRETDLIQYAEHLDFPIIPCNLCGSQENLQRQNIKAMLIDWDKQTPGR
CCCEEEECCHHHHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHHCCEEEEEECCCCCCHH
VEKIFKSIQNVSPSQLADRELFDFVNLPLDRSEDRKAYEFEEAEISSSNIDESMFIDVTN
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEEC
V
C
>Mature Secondary Structure
MRVAMNQNENKKETLEFNKLQKRLRRNVGNAIVDYNMIEENDVVMACISGGKDSFAMLDI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEECEEECCCCEEEEEECCCCCHHHHHHH
LLRLREAAPIKFDVVAVNLDQKQPGFPEHILPEYFETLNIPYYIVDKDTYSVVKEKVPEG
HHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCC
KTTCGLCSRLRRGTLYSFAEKIGATKIALGHHLDDIVETMFLNMFHGARLKAMPPKLRSD
CCHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
DGRNVVIRPLTYCRETDLIQYAEHLDFPIIPCNLCGSQENLQRQNIKAMLIDWDKQTPGR
CCCEEEECCHHHHHHHHHHHHHHHCCCCEEEHHCCCCHHHHHHHCCEEEEEECCCCCCHH
VEKIFKSIQNVSPSQLADRELFDFVNLPLDRSEDRKAYEFEEAEISSSNIDESMFIDVTN
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEEEC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA