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The map label for this gene is maeA1 [H]

Identifier: 218709195

GI number: 218709195

Start: 1274115

End: 1275803

Strand: Reverse

Name: maeA1 [H]

Synonym: VS_1202

Alternate gene names: 218709195

Gene position: 1275803-1274115 (Counterclockwise)

Preceding gene: 218709198

Following gene: 218709194

Centisome position: 38.67

GC content: 47.19

Gene sequence:

>1689_bases
ATGAACAACGATAAACGCCCTCTATATATCCCTTATGCTGGTCCTGCTCTACTAAGTACCCCTCTTCTAAACAAAGGCAG
CGCATTCTCTGCTGAAGAGCGCAGTTCTTTCAACCTTGAAGGCTTGTTACCTGAAACGACCGAAACAATCCAAGAGCAAG
TAGGACGTGCATACAAGCAATATTGTAACTTCGAAAGTGATATGGATAAGCATATCTACCTTCGTAACATCCAAGACACT
AATGAAACGCTTTTTTATCGTTTAGTTCAAAACCACATTTCTGAAATGATGCCTATCATTTACACGCCAACAGTTGGCGC
AGCATGTGAGAACTTCTCAAATATTTACCGTCGTGGCCGTGGTCTGTTTATCTCATACCCGAACCGCGATCGTATCGATG
ACCTACTGAACAATGCGACAAACCACAACGTTAAAGTTATCGTGGTTACGGATGGTGAGCGTATTCTTGGTTTGGGAGAC
CAAGGTATCGGTGGCATGGGTATTCCAATTGGTAAACTAGCACTTTACACAGCTTGTGGCGGCATCAGCCCAGCTTACAT
GCTACCAATCGTGCTCGATGTGGGTACAAACAACCCGCAGCGTCTTGCAGACCCAATGTACATGGGCTGGCGTCACCCTC
GTATCACGGGTGCTGATTACGATGCATTTGTTGAAGAATTCATTCAAGCCGTTCAACGCCGTTGGCCTGATGCATTAGTT
CAGTTCGAAGATTTCGCACAAAAGAACGCAATGCCACTACTTGAACGCTACAAAGATCGCCTTTGTTGTTTCAACGATGA
TATCCAAGGCACAGCCGCTGTAACGGTTGGTTCTCTACTTGCAGCATGTAAAGCAGCGAACAGCAAACTATCAGACCAAC
GCATCACCTTCTTAGGTGCGGGTTCTGCAGGTTGTGGTATTGCTGAAGCTATCATTGCTCAAATGGTGTCTGAAGGTATC
AGCGATGCACAAGCTCGCTCTCAAGTTTACATGGTTGACCGTTGGGGTCTGCTACAGGAAGGCATGCAAAACCTGCTTGA
TTTCCAACAGCGTCTAGTTCAAACCAACGCGAACACCAAAGATTGGGAAAGCGATGGTACTGGTTTCTCTCTACTAGACG
TTGTTCGTCACGCGAAACCTACGGTATTGGTTGGCGTATCTGGTGCGCCGGGTCTGTTCAGCAAAGAAGTCATCAAAGAG
ATGAACCTGCACTGCGAACGCCCTATCGTGTTCCCACTGTCAAACCCAACAAGCCGTGTTGAAGCAACACCAAATGACAT
TATTCGTTGGACTGACGGCCAAGCGCTTGTTGCGACTGGTAGCCCATTTGAGCCGGTGGTTCACAACGGCACCACTTACC
CAATCGCTCAGTGTAATAACAGCTACATCTTCCCAGGTATTGGCCTTGGTGTATTGGCTGTGAATGCTTCACGCATCACT
GACGAAATGCTAATGGAATCAAGCCGAGCACTTGCAACGTGTTCTCCACTTGCTATCAATGGCTCAGGTGCTCTACTTCC
ACCATTGGAAGAGATCCACACCGTATCTAAGAAGATTGCTTTTGCCGTTGGTAAAAAAGCGATTGAGCAAGGTGTTGCTC
TAGAGATCACTGAAGAAGCACTACAACAAGCGATAGACCAGCACTTCTGGCAGCCGGTTTACCGTCGCTACAAGCGTACT
GCATTCTAA

Upstream 100 bases:

>100_bases
ATATCATTTTGTTTGCAAAGATCGGAGGTAAACTATTTACAATTGAATAACTAAACCGTTATCATTTTTCGGTTACCCTT
TCTCCCATATTAGGCATCTA

Downstream 100 bases:

>100_bases
TAAACGTGCTGCGCTTGGAATAAAGAGCGTTAACTACTCTTACAAGAGCCTCTGCAACTGCGGGGGCTTTTTTCTTTACA
CTGTCTTGTCTTTTTAACTG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME 1 [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNNDKRPLYIPYAGPALLSTPLLNKGSAFSAEERSSFNLEGLLPETTETIQEQVGRAYKQYCNFESDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYPNRDRIDDLLNNATNHNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAYMLPIVLDVGTNNPQRLADPMYMGWRHPRITGADYDAFVEEFIQAVQRRWPDALV
QFEDFAQKNAMPLLERYKDRLCCFNDDIQGTAAVTVGSLLAACKAANSKLSDQRITFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMQNLLDFQQRLVQTNANTKDWESDGTGFSLLDVVRHAKPTVLVGVSGAPGLFSKEVIKE
MNLHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFEPVVHNGTTYPIAQCNNSYIFPGIGLGVLAVNASRIT
DEMLMESSRALATCSPLAINGSGALLPPLEEIHTVSKKIAFAVGKKAIEQGVALEITEEALQQAIDQHFWQPVYRRYKRT
AF

Sequences:

>Translated_562_residues
MNNDKRPLYIPYAGPALLSTPLLNKGSAFSAEERSSFNLEGLLPETTETIQEQVGRAYKQYCNFESDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYPNRDRIDDLLNNATNHNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAYMLPIVLDVGTNNPQRLADPMYMGWRHPRITGADYDAFVEEFIQAVQRRWPDALV
QFEDFAQKNAMPLLERYKDRLCCFNDDIQGTAAVTVGSLLAACKAANSKLSDQRITFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMQNLLDFQQRLVQTNANTKDWESDGTGFSLLDVVRHAKPTVLVGVSGAPGLFSKEVIKE
MNLHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFEPVVHNGTTYPIAQCNNSYIFPGIGLGVLAVNASRIT
DEMLMESSRALATCSPLAINGSGALLPPLEEIHTVSKKIAFAVGKKAIEQGVALEITEEALQQAIDQHFWQPVYRRYKRT
AF
>Mature_562_residues
MNNDKRPLYIPYAGPALLSTPLLNKGSAFSAEERSSFNLEGLLPETTETIQEQVGRAYKQYCNFESDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYPNRDRIDDLLNNATNHNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAYMLPIVLDVGTNNPQRLADPMYMGWRHPRITGADYDAFVEEFIQAVQRRWPDALV
QFEDFAQKNAMPLLERYKDRLCCFNDDIQGTAAVTVGSLLAACKAANSKLSDQRITFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMQNLLDFQQRLVQTNANTKDWESDGTGFSLLDVVRHAKPTVLVGVSGAPGLFSKEVIKE
MNLHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFEPVVHNGTTYPIAQCNNSYIFPGIGLGVLAVNASRIT
DEMLMESSRALATCSPLAINGSGALLPPLEEIHTVSKKIAFAVGKKAIEQGVALEITEEALQQAIDQHFWQPVYRRYKRT
AF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=522, Percent_Identity=44.4444444444444, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI62420882, Length=530, Percent_Identity=42.4528301886792, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI62420880, Length=530, Percent_Identity=42.4528301886792, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI239049447, Length=530, Percent_Identity=42.4528301886792, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI4505145, Length=552, Percent_Identity=42.0289855072464, Blast_Score=424, Evalue=1e-118,
Organism=Homo sapiens, GI270265879, Length=463, Percent_Identity=44.9244060475162, Blast_Score=390, Evalue=1e-108,
Organism=Escherichia coli, GI87081919, Length=558, Percent_Identity=69.7132616487455, Blast_Score=800, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=546, Percent_Identity=43.040293040293, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322823, Length=566, Percent_Identity=44.5229681978799, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI281362674, Length=518, Percent_Identity=43.4362934362934, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI21356279, Length=518, Percent_Identity=43.4362934362934, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281362672, Length=518, Percent_Identity=43.4362934362934, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24646388, Length=513, Percent_Identity=41.5204678362573, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24646386, Length=513, Percent_Identity=41.5204678362573, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI78707242, Length=534, Percent_Identity=38.2022471910112, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI78707238, Length=534, Percent_Identity=38.2022471910112, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI78707240, Length=515, Percent_Identity=38.8349514563107, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707232, Length=509, Percent_Identity=37.524557956778, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363505, Length=511, Percent_Identity=37.1819960861057, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI78707236, Length=511, Percent_Identity=37.1819960861057, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI281363503, Length=509, Percent_Identity=36.9351669941061, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19922384, Length=544, Percent_Identity=29.4117647058824, Blast_Score=250, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 61968; Mature: 61968

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00331 MALIC_ENZYMES ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDKRPLYIPYAGPALLSTPLLNKGSAFSAEERSSFNLEGLLPETTETIQEQVGRAYKQ
CCCCCCEEEEECCCHHHHHCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
YCNFESDMDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGR
HCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCC
GLFISYPNRDRIDDLLNNATNHNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACG
EEEEECCCCHHHHHHHCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHC
GISPAYMLPIVLDVGTNNPQRLADPMYMGWRHPRITGADYDAFVEEFIQAVQRRWPDALV
CCCHHHEEEEEEECCCCCHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHH
QFEDFAQKNAMPLLERYKDRLCCFNDDIQGTAAVTVGSLLAACKAANSKLSDQRITFLGA
HHHHHHHHCCHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAGCGIAEAIIAQMVSEGISDAQARSQVYMVDRWGLLQEGMQNLLDFQQRLVQTNANTK
CCCCCHHHHHHHHHHHHHCCCHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DWESDGTGFSLLDVVRHAKPTVLVGVSGAPGLFSKEVIKEMNLHCERPIVFPLSNPTSRV
CCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCC
EATPNDIIRWTDGQALVATGSPFEPVVHNGTTYPIAQCNNSYIFPGIGLGVLAVNASRIT
CCCCCCCEEECCCCEEEECCCCCCCHHCCCCCCCCEECCCCEECCCCCCCCEEECHHHHH
DEMLMESSRALATCSPLAINGSGALLPPLEEIHTVSKKIAFAVGKKAIEQGVALEITEEA
HHHHHHCCCCCEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
LQQAIDQHFWQPVYRRYKRTAF
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNDKRPLYIPYAGPALLSTPLLNKGSAFSAEERSSFNLEGLLPETTETIQEQVGRAYKQ
CCCCCCEEEEECCCHHHHHCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
YCNFESDMDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGR
HCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCC
GLFISYPNRDRIDDLLNNATNHNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACG
EEEEECCCCHHHHHHHCCCCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHC
GISPAYMLPIVLDVGTNNPQRLADPMYMGWRHPRITGADYDAFVEEFIQAVQRRWPDALV
CCCHHHEEEEEEECCCCCHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHH
QFEDFAQKNAMPLLERYKDRLCCFNDDIQGTAAVTVGSLLAACKAANSKLSDQRITFLGA
HHHHHHHHCCHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEC
GSAGCGIAEAIIAQMVSEGISDAQARSQVYMVDRWGLLQEGMQNLLDFQQRLVQTNANTK
CCCCCHHHHHHHHHHHHHCCCHHHHHCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DWESDGTGFSLLDVVRHAKPTVLVGVSGAPGLFSKEVIKEMNLHCERPIVFPLSNPTSRV
CCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCC
EATPNDIIRWTDGQALVATGSPFEPVVHNGTTYPIAQCNNSYIFPGIGLGVLAVNASRIT
CCCCCCCEEECCCCEEEECCCCCCCHHCCCCCCCCEECCCCEECCCCCCCCEEECHHHHH
DEMLMESSRALATCSPLAINGSGALLPPLEEIHTVSKKIAFAVGKKAIEQGVALEITEEA
HHHHHHCCCCCEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHH
LQQAIDQHFWQPVYRRYKRTAF
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA