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The map label for this gene is hisQ [H]

Identifier: 218709050

GI number: 218709050

Start: 1107019

End: 1107759

Strand: Direct

Name: hisQ [H]

Synonym: VS_1056

Alternate gene names: 218709050

Gene position: 1107019-1107759 (Clockwise)

Preceding gene: 218709049

Following gene: 218709051

Centisome position: 33.55

GC content: 45.48

Gene sequence:

>741_bases
ATGTTTGATTTACAAGGATATGAAGCGTCGATCCTGAAAGGGGCGGTGCTTACAATCGAAGTTGCCTTACTGTCGCTAAT
TTTAGCTATGGTTCTTGGTATGCTAGGTGCCTTAGCTAAACTCGCGCCTTATCGCTGGGCTCGTGCTATTGCAACCCTCT
ACACAACCGTTATTCGAGGTATCCCCGATCTCGTATTGATGATGCTGATTTTCTTTGGTGGACAAATCCTTTTAAACAAC
AGTTTGTATTCCATCAATGAGTGGCTCAATGAGTGGTTCACATCAAGTGACCCTAACCACGAATGGACCGCTTACCTACC
TGATTATATTGATGTTAGCCCATTTATTGCTGGTGTCTTAACCATTGGCTTCATCTTTGGCGCGTACATGGCAGAAACCT
TCCGTGGTGCAATAATGGCTGTCGACAGCGGTGAGATGGAAGCGGCAAAGGCTTATGGCATGGGCCCTGTTTTAGCGTTC
CGTCGTATTCTATTACCGCAAATGATTCGTCACGCACTGCCAGGGTTTGGTAATAACTGGTTGGTTTTACTAAAAACTAC
CGCGCTGGTTTCTATTATTGGCCTTGAAGACATGGTACGTGTTAGCGCTCTGGCGGCGGGTTCAACCAAAATGCCATTTA
CCTTCTATATGACGGTAGCAATCATCTTCTTATTCTTCACCAGTGTTTCGACGGGCTTACTTAAGTTGGTTGAACGTAAA
TTCAGTATCCACGCGAGGTAG

Upstream 100 bases:

>100_bases
TACGACGTATACGGTAAGTAATCTCTAGCGTCACTTCTTAAGGGAGAGGCTCACCTCTCCCTGTCTTACCAACTTTTTCG
CAGTTCTGTTGGAATTCATT

Downstream 100 bases:

>100_bases
TTATGGACTTTTCATTGATAATTGAAAGCCTGCCGATTTACCTTGGTGGTTTGTGGACAACGGCTTGGATGGTTTGTGTC
GCTTTGATTGTTGGCTTATT

Product: histidine transport system permease HisQ

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MFDLQGYEASILKGAVLTIEVALLSLILAMVLGMLGALAKLAPYRWARAIATLYTTVIRGIPDLVLMMLIFFGGQILLNN
SLYSINEWLNEWFTSSDPNHEWTAYLPDYIDVSPFIAGVLTIGFIFGAYMAETFRGAIMAVDSGEMEAAKAYGMGPVLAF
RRILLPQMIRHALPGFGNNWLVLLKTTALVSIIGLEDMVRVSALAAGSTKMPFTFYMTVAIIFLFFTSVSTGLLKLVERK
FSIHAR

Sequences:

>Translated_246_residues
MFDLQGYEASILKGAVLTIEVALLSLILAMVLGMLGALAKLAPYRWARAIATLYTTVIRGIPDLVLMMLIFFGGQILLNN
SLYSINEWLNEWFTSSDPNHEWTAYLPDYIDVSPFIAGVLTIGFIFGAYMAETFRGAIMAVDSGEMEAAKAYGMGPVLAF
RRILLPQMIRHALPGFGNNWLVLLKTTALVSIIGLEDMVRVSALAAGSTKMPFTFYMTVAIIFLFFTSVSTGLLKLVERK
FSIHAR
>Mature_246_residues
MFDLQGYEASILKGAVLTIEVALLSLILAMVLGMLGALAKLAPYRWARAIATLYTTVIRGIPDLVLMMLIFFGGQILLNN
SLYSINEWLNEWFTSSDPNHEWTAYLPDYIDVSPFIAGVLTIGFIFGAYMAETFRGAIMAVDSGEMEAAKAYGMGPVLAF
RRILLPQMIRHALPGFGNNWLVLLKTTALVSIIGLEDMVRVSALAAGSTKMPFTFYMTVAIIFLFFTSVSTGLLKLVERK
FSIHAR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=243, Percent_Identity=46.5020576131687, Blast_Score=216, Evalue=9e-58,
Organism=Escherichia coli, GI1787087, Length=239, Percent_Identity=35.5648535564854, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1788226, Length=237, Percent_Identity=27.4261603375527, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1788645, Length=233, Percent_Identity=27.4678111587983, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787030, Length=233, Percent_Identity=27.4678111587983, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1786874, Length=235, Percent_Identity=24.6808510638298, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 27165; Mature: 27165

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLQGYEASILKGAVLTIEVALLSLILAMVLGMLGALAKLAPYRWARAIATLYTTVIRG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IPDLVLMMLIFFGGQILLNNSLYSINEWLNEWFTSSDPNHEWTAYLPDYIDVSPFIAGVL
CHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHH
TIGFIFGAYMAETFRGAIMAVDSGEMEAAKAYGMGPVLAFRRILLPQMIRHALPGFGNNW
HHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCE
LVLLKTTALVSIIGLEDMVRVSALAAGSTKMPFTFYMTVAIIFLFFTSVSTGLLKLVERK
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSIHAR
HHCCCC
>Mature Secondary Structure
MFDLQGYEASILKGAVLTIEVALLSLILAMVLGMLGALAKLAPYRWARAIATLYTTVIRG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IPDLVLMMLIFFGGQILLNNSLYSINEWLNEWFTSSDPNHEWTAYLPDYIDVSPFIAGVL
CHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHH
TIGFIFGAYMAETFRGAIMAVDSGEMEAAKAYGMGPVLAFRRILLPQMIRHALPGFGNNW
HHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCE
LVLLKTTALVSIIGLEDMVRVSALAAGSTKMPFTFYMTVAIIFLFFTSVSTGLLKLVERK
EEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSIHAR
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]