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The map label for this gene is hisM [H]

Identifier: 218709051

GI number: 218709051

Start: 1107762

End: 1108439

Strand: Direct

Name: hisM [H]

Synonym: VS_1057

Alternate gene names: 218709051

Gene position: 1107762-1108439 (Clockwise)

Preceding gene: 218709050

Following gene: 218709052

Centisome position: 33.58

GC content: 43.51

Gene sequence:

>678_bases
ATGGACTTTTCATTGATAATTGAAAGCCTGCCGATTTACCTTGGTGGTTTGTGGACAACGGCTTGGATGGTTTGTGTCGC
TTTGATTGTTGGCTTATTCGTAGCCATACCATTAGCTATCGCTCGTAACAGTCCAAATATGATGATTAATGCACCAGCTT
GGTCGTTCATTTATTTCTTCCGTGGTACGCCGTTATTGGTTCAGTTGTACCTGATTTACTACGGTATGGACCAATTCTTC
CCAGTAAAAGATACACTATGGGAAAACGCGTGGTTCTGTGCTTTAGTTGCGTTTATTCTGAACACATCAGCATATACTGC
AGAGATCATTCGTGGTGCTATTAATGGCTTACCGAAAGGTGAGGTTGAAGCCGCGAAAGCGTACGGCATGAGCACACCAA
AGACTTACCGCCGCATCATTTTGCCAAGTGCTCTACGTCGTGCATTACCGGCTTACAGTAACGAAGTTATCTTTATGCTT
CATGGTTCAGCGGTAGCAGGTATTGTAACCATTATGGATCTAACTGGTGCTGCACGTTTGGTTAACTCTCGCTACTACGC
TCCATTCGAGTCTTTCCTAACTGCAGGTTTATTCTACATGGCGCTAACGTTTATCATCATTGCGATTTTCAAATTCGCAG
AGAAGCGTTTCCTTGCTTACTTAAGGCCGTTAAGTTAA

Upstream 100 bases:

>100_bases
TCTATATGACGGTAGCAATCATCTTCTTATTCTTCACCAGTGTTTCGACGGGCTTACTTAAGTTGGTTGAACGTAAATTC
AGTATCCACGCGAGGTAGTT

Downstream 100 bases:

>100_bases
CTCTACGATACAGATTTTCTTAGATAAACGGCGCTCTTGTAGCGCCGTTTTTAATTTCAATTCAATTGTTCGGGTACCAA
TAAGTTTAAGTGGTATTTGT

Product: histidine transport system permease HisM

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MDFSLIIESLPIYLGGLWTTAWMVCVALIVGLFVAIPLAIARNSPNMMINAPAWSFIYFFRGTPLLVQLYLIYYGMDQFF
PVKDTLWENAWFCALVAFILNTSAYTAEIIRGAINGLPKGEVEAAKAYGMSTPKTYRRIILPSALRRALPAYSNEVIFML
HGSAVAGIVTIMDLTGAARLVNSRYYAPFESFLTAGLFYMALTFIIIAIFKFAEKRFLAYLRPLS

Sequences:

>Translated_225_residues
MDFSLIIESLPIYLGGLWTTAWMVCVALIVGLFVAIPLAIARNSPNMMINAPAWSFIYFFRGTPLLVQLYLIYYGMDQFF
PVKDTLWENAWFCALVAFILNTSAYTAEIIRGAINGLPKGEVEAAKAYGMSTPKTYRRIILPSALRRALPAYSNEVIFML
HGSAVAGIVTIMDLTGAARLVNSRYYAPFESFLTAGLFYMALTFIIIAIFKFAEKRFLAYLRPLS
>Mature_225_residues
MDFSLIIESLPIYLGGLWTTAWMVCVALIVGLFVAIPLAIARNSPNMMINAPAWSFIYFFRGTPLLVQLYLIYYGMDQFF
PVKDTLWENAWFCALVAFILNTSAYTAEIIRGAINGLPKGEVEAAKAYGMSTPKTYRRIILPSALRRALPAYSNEVIFML
HGSAVAGIVTIMDLTGAARLVNSRYYAPFESFLTAGLFYMALTFIIIAIFKFAEKRFLAYLRPLS

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=215, Percent_Identity=48.8372093023256, Blast_Score=194, Evalue=3e-51,
Organism=Escherichia coli, GI1787086, Length=220, Percent_Identity=34.5454545454545, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI1788226, Length=198, Percent_Identity=37.8787878787879, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787030, Length=215, Percent_Identity=30.6976744186047, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1786874, Length=218, Percent_Identity=28.8990825688073, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1787087, Length=224, Percent_Identity=25.4464285714286, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788646, Length=203, Percent_Identity=27.5862068965517, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI87082239, Length=206, Percent_Identity=30.0970873786408, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1786873, Length=222, Percent_Identity=28.3783783783784, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 25207; Mature: 25207

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSLIIESLPIYLGGLWTTAWMVCVALIVGLFVAIPLAIARNSPNMMINAPAWSFIYFF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHH
RGTPLLVQLYLIYYGMDQFFPVKDTLWENAWFCALVAFILNTSAYTAEIIRGAINGLPKG
CCCHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
EVEAAKAYGMSTPKTYRRIILPSALRRALPAYSNEVIFMLHGSAVAGIVTIMDLTGAARL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
VNSRYYAPFESFLTAGLFYMALTFIIIAIFKFAEKRFLAYLRPLS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDFSLIIESLPIYLGGLWTTAWMVCVALIVGLFVAIPLAIARNSPNMMINAPAWSFIYFF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHH
RGTPLLVQLYLIYYGMDQFFPVKDTLWENAWFCALVAFILNTSAYTAEIIRGAINGLPKG
CCCHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCC
EVEAAKAYGMSTPKTYRRIILPSALRRALPAYSNEVIFMLHGSAVAGIVTIMDLTGAARL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHH
VNSRYYAPFESFLTAGLFYMALTFIIIAIFKFAEKRFLAYLRPLS
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]