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The map label for this gene is nhaB

Identifier: 218709000

GI number: 218709000

Start: 1042085

End: 1043677

Strand: Reverse

Name: nhaB

Synonym: VS_1006

Alternate gene names: 218709000

Gene position: 1043677-1042085 (Counterclockwise)

Preceding gene: 218709002

Following gene: 218708999

Centisome position: 31.63

GC content: 45.26

Gene sequence:

>1593_bases
ATGCCGATGTCTCTCGGAAACGCTTTTATCAAAAACTTCCTTGGTAAAGCTCCTGATTGGTATAAACTTGCCATCATTTC
CTTTTTAATCATCAACCCGTTTGTTTTTTTCCTAGTTGACCCATTCGTTGCGGGCTGGCTATTAGTGGTTGAGTTTATTT
TCACTCTAGCTATGGCTCTAAAGTGCTACCCTCTCCAACCCGGTGGCTTATTGGCAATTCAAGCCGTCGCCATTGGCATG
ACTAAACCAGAAATGGTATATCATGAGCTACAAGCAAACCTACCAGTATTACTCTTACTAGTATTCATGGTTGCTGGCAT
CTACTTCATGAAAGAACTACTTCTGTTCATTTTTACGAAGATCCTGCTCGGTATCCAATCCAAAATTCTACTCTCTGTCG
CTTTCTGTGTCGCCGCAGCATTCTTGTCTGCCTTCCTAGATGCGCTGACAGTAATCGCCGTAGTCATTAGCGTTGCGGTG
GGCTTCTACTCTATCTACCACAAGGTTGCATCAGGTAAAGGCACAACGTCTGCACACGATCATACTCATGATGAAGAGAT
CTCTGAGCTAACTCGTGATGACCTAGAAAACTACCGCGCATTCCTACGTTCACTACTTATGCACGCCGGTGTTGGTACTG
CTCTGGGTGGTGTAATGACCATGGTAGGTGAACCACAAAACTTAGTAATTGCTAAGCAAGCGGGTTGGGAGTTCGGTGAA
TTTATCATCCGCATGCTGCCAGTAACACTGCCTGTTTTCTTCTGTGGTATTTTAACTTGTGCACTTGTCGAGAAATTCAA
AGTGTTTGGCTACGGTGCGGAGCTGCCAAATAACGTTCGCCAAATCTTAGTTGAATTTGACAACAAAGAACGCGCAAATC
GTACAAAACAAGACGTAGCTAAACTATGGGTTCAAAGTGCAATCGCAGTTTGGCTTATCGTAGGCCTTGCGCTTCACGTC
GCTGAAGTCGGTTTGATTGGCCTTTCAGTGATCATCTTAGCTACAGCGTTTACAGGTGTAATTGAAGAACACTCGATGGG
TAAAGCCTTTGAAGAAGCACTGCCATTTACTGCACTTCTTGCCGTCTTTTTCGCGGTTGTTGCTGTAATCATCGACCAGG
CTCTATTTAAGCCAGTAATCGATGCCGTACTTCACGTTGAAGATAAAGGCGCACAGCTCGCACTCTTCTACGTAGCCAAC
GGTATTTTGTCGATGGTTTCAGACAACGTATTCGTCGGTACGGTTTACATCAACGAAGTTAAAACAGCTCTGGTTGAAGG
CGTCATCACTCGTGACCAATTTGATCTGCTTGCTGTTGCTATCAACACTGGTACCAACCTACCTTCTGTTGCTACGCCAA
ACGGCCAAGCTGCATTCCTATTCCTATTAACGTCAGCACTTGCTCCGTTAATTCGACTGTCTTACGGCCGCATGGTAATC
ATGGCTTTGCCATATACTATCGTATTAGCACTTGTTGGCCTTGCTGGTATTGTGTTCTTCGTAGAACCGATGACAGCATG
GTTCTATGATGCAGGTTGGATCATTCACCGTACGGGTGAAGTGGTAGCTCCAGTTATCTCCGGTGGTCACTAA

Upstream 100 bases:

>100_bases
CTAAGTCACTGTTAGTTATAGGTTTTAACTAAACCTACAACTCGATTCTCAAAATGTTGTATTGCTTGTCTATTCATAAT
CAACATAAAAGAGTATTAAC

Downstream 100 bases:

>100_bases
CCCGGATTTCTATAGCTAAACACAATAGATACATCTAACTAATCAAAAATATTAGTTGATTAGGAAACTTATCCAAGATA
AAAAGCTCTGAGTAATCAGG

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MPMSLGNAFIKNFLGKAPDWYKLAIISFLIINPFVFFLVDPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TKPEMVYHELQANLPVLLLLVFMVAGIYFMKELLLFIFTKILLGIQSKILLSVAFCVAAAFLSAFLDALTVIAVVISVAV
GFYSIYHKVASGKGTTSAHDHTHDEEISELTRDDLENYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLVIAKQAGWEFGE
FIIRMLPVTLPVFFCGILTCALVEKFKVFGYGAELPNNVRQILVEFDNKERANRTKQDVAKLWVQSAIAVWLIVGLALHV
AEVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALLAVFFAVVAVIIDQALFKPVIDAVLHVEDKGAQLALFYVAN
GILSMVSDNVFVGTVYINEVKTALVEGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVI
MALPYTIVLALVGLAGIVFFVEPMTAWFYDAGWIIHRTGEVVAPVISGGH

Sequences:

>Translated_530_residues
MPMSLGNAFIKNFLGKAPDWYKLAIISFLIINPFVFFLVDPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIQAVAIGM
TKPEMVYHELQANLPVLLLLVFMVAGIYFMKELLLFIFTKILLGIQSKILLSVAFCVAAAFLSAFLDALTVIAVVISVAV
GFYSIYHKVASGKGTTSAHDHTHDEEISELTRDDLENYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLVIAKQAGWEFGE
FIIRMLPVTLPVFFCGILTCALVEKFKVFGYGAELPNNVRQILVEFDNKERANRTKQDVAKLWVQSAIAVWLIVGLALHV
AEVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALLAVFFAVVAVIIDQALFKPVIDAVLHVEDKGAQLALFYVAN
GILSMVSDNVFVGTVYINEVKTALVEGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVI
MALPYTIVLALVGLAGIVFFVEPMTAWFYDAGWIIHRTGEVVAPVISGGH
>Mature_529_residues
PMSLGNAFIKNFLGKAPDWYKLAIISFLIINPFVFFLVDPFVAGWLLVVEFIFTLAMALKCYPLQPGGLLAIQAVAIGMT
KPEMVYHELQANLPVLLLLVFMVAGIYFMKELLLFIFTKILLGIQSKILLSVAFCVAAAFLSAFLDALTVIAVVISVAVG
FYSIYHKVASGKGTTSAHDHTHDEEISELTRDDLENYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLVIAKQAGWEFGEF
IIRMLPVTLPVFFCGILTCALVEKFKVFGYGAELPNNVRQILVEFDNKERANRTKQDVAKLWVQSAIAVWLIVGLALHVA
EVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALLAVFFAVVAVIIDQALFKPVIDAVLHVEDKGAQLALFYVANG
ILSMVSDNVFVGTVYINEVKTALVEGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVIM
ALPYTIVLALVGLAGIVFFVEPMTAWFYDAGWIIHRTGEVVAPVISGGH

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family

Homologues:

Organism=Escherichia coli, GI1787435, Length=514, Percent_Identity=69.4552529182879, Blast_Score=680, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAB_VIBSL (B7VLW5)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416621.1
- GeneID:   7160598
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_1006
- HOGENOM:   HBG296776
- OMA:   CFLVEKF
- ProtClustDB:   PRK09547
- HAMAP:   MF_01599
- InterPro:   IPR004671
- TIGRFAMs:   TIGR00774

Pfam domain/function: PF06450 NhaB

EC number: NA

Molecular weight: Translated: 57640; Mature: 57509

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1a7cdc4c)-; HASH(0x189b803c)-; HASH(0x19260d14)-; HASH(0x1a578900)-; HASH(0x1ac79664)-; HASH(0x1acd3ea8)-; HASH(0x1acc5aa8)-; HASH(0x1ad3d148)-; HASH(0x1a903a00)-; HASH(0x1aca2960)-; HASH(0x1a2ef73c)-; HASH(0x1ad16308)-; HASH(0x1a5a3428)-; HASH(0x1adc42a4)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSLGNAFIKNFLGKAPDWYKLAIISFLIINPFVFFLVDPFVAGWLLVVEFIFTLAMAL
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KCYPLQPGGLLAIQAVAIGMTKPEMVYHELQANLPVLLLLVFMVAGIYFMKELLLFIFTK
HCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLGIQSKILLSVAFCVAAAFLSAFLDALTVIAVVISVAVGFYSIYHKVASGKGTTSAHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
HTHDEEISELTRDDLENYRAFLRSLLMHAGVGTALGGVMTMVGEPQNLVIAKQAGWEFGE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHH
FIIRMLPVTLPVFFCGILTCALVEKFKVFGYGAELPNNVRQILVEFDNKERANRTKQDVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
KLWVQSAIAVWLIVGLALHVAEVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
AVFFAVVAVIIDQALFKPVIDAVLHVEDKGAQLALFYVANGILSMVSDNVFVGTVYINEV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCEEEEEEEHHHH
KTALVEGVITRDQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVI
HHHHHHHHHCCCCHHHEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
MALPYTIVLALVGLAGIVFFVEPMTAWFYDAGWIIHRTGEVVAPVISGGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCH
>Mature Secondary Structure 
PMSLGNAFIKNFLGKAPDWYKLAIISFLIINPFVFFLVDPFVAGWLLVVEFIFTLAMAL
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA