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The map label for this gene is apt

Identifier: 218708913

GI number: 218708913

Start: 940969

End: 941514

Strand: Direct

Name: apt

Synonym: VS_0914

Alternate gene names: 218708913

Gene position: 940969-941514 (Clockwise)

Preceding gene: 218708912

Following gene: 218708914

Centisome position: 28.52

GC content: 45.79

Gene sequence:

>546_bases
ATGAACACAGAAAAAATCTCTCTGATCAAAGCAAGCATCAAAAGCATTCCTGATTACCCAAAAGCGGGTATTTTGTTCCG
TGACGTAACAAGCTTGATGGAAGATCCTGCCGCTTACAAAGCGACAATCGATCTGTTGGTGGACACATACAAGGGCATGG
GCTTTACTAAGATCGTTGGTACTGAAGCTCGTGGTTTCCTATTTGGTGCGCCTTTGGCACTAGAGCTAGGTGTTGGCTTC
ATTCCTGTTCGTAAACCGGGCAAGTTGCCTCGTCAAACTGTGGCACAATCTTATGAGCTTGAGTACGGCACTGATACGCT
AGAAATTCATACCGATGCTATCGTTGAAGGCGATAAAGTGCTGATGGTTGATGACTTGTTAGCAACAGGCGGTACGATTG
AAGCGACAACGAAGCTGATTCGTCAGCTTGGTGGTGTGGTTGAACACGCTGCATTTGTTATTAACCTTCCAGAAATCGGT
GGTGATAAGCGCTTACAAGGCTTAGGTCTAGAAGTGTTTAGCATCTGCGAATTCGACGGTCACTAA

Upstream 100 bases:

>100_bases
GTTGCAATGAATACCAATCGTACCTTTCCTTAATTCCGAGCGTTGATGTTTGATTCGTTAACGAGAGTTTGGAAAGCGGC
CTAATGAAGTGCATAAGATT

Downstream 100 bases:

>100_bases
TCCTTTTCGGAATTATTCATGAGCTATCTTGCGTTAGCGCGAAAATGGCGACCAACCAAATTCAAAGAAGTGGTTGGTCA
AGCCCATGTTTTAACAGCAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MNTEKISLIKASIKSIPDYPKAGILFRDVTSLMEDPAAYKATIDLLVDTYKGMGFTKIVGTEARGFLFGAPLALELGVGF
IPVRKPGKLPRQTVAQSYELEYGTDTLEIHTDAIVEGDKVLMVDDLLATGGTIEATTKLIRQLGGVVEHAAFVINLPEIG
GDKRLQGLGLEVFSICEFDGH

Sequences:

>Translated_181_residues
MNTEKISLIKASIKSIPDYPKAGILFRDVTSLMEDPAAYKATIDLLVDTYKGMGFTKIVGTEARGFLFGAPLALELGVGF
IPVRKPGKLPRQTVAQSYELEYGTDTLEIHTDAIVEGDKVLMVDDLLATGGTIEATTKLIRQLGGVVEHAAFVINLPEIG
GDKRLQGLGLEVFSICEFDGH
>Mature_181_residues
MNTEKISLIKASIKSIPDYPKAGILFRDVTSLMEDPAAYKATIDLLVDTYKGMGFTKIVGTEARGFLFGAPLALELGVGF
IPVRKPGKLPRQTVAQSYELEYGTDTLEIHTDAIVEGDKVLMVDDLLATGGTIEATTKLIRQLGGVVEHAAFVINLPEIG
GDKRLQGLGLEVFSICEFDGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=182, Percent_Identity=40.1098901098901, Blast_Score=137, Evalue=7e-33,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=46.6165413533835, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1786675, Length=180, Percent_Identity=67.7777777777778, Blast_Score=251, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=42.0731707317073, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=40.4907975460123, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=175, Percent_Identity=36.5714285714286, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136334, Length=166, Percent_Identity=46.3855421686747, Blast_Score=137, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_VIBSL (B7VL95)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416534.1
- ProteinModelPortal:   B7VL95
- SMR:   B7VL95
- GeneID:   7160511
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0914
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19540; Mature: 19540

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTEKISLIKASIKSIPDYPKAGILFRDVTSLMEDPAAYKATIDLLVDTYKGMGFTKIVG
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEC
TEARGFLFGAPLALELGVGFIPVRKPGKLPRQTVAQSYELEYGTDTLEIHTDAIVEGDKV
CCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEECEEECCCEE
LMVDDLLATGGTIEATTKLIRQLGGVVEHAAFVINLPEIGGDKRLQGLGLEVFSICEFDG
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEEEEECCC
H
C
>Mature Secondary Structure
MNTEKISLIKASIKSIPDYPKAGILFRDVTSLMEDPAAYKATIDLLVDTYKGMGFTKIVG
CCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEC
TEARGFLFGAPLALELGVGFIPVRKPGKLPRQTVAQSYELEYGTDTLEIHTDAIVEGDKV
CCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHHHHHCCCCCCCEEEEEECEEECCCEE
LMVDDLLATGGTIEATTKLIRQLGGVVEHAAFVINLPEIGGDKRLQGLGLEVFSICEFDG
EEEEHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCEEEEEEECCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA