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The map label for this gene is dnaX [H]

Identifier: 218708914

GI number: 218708914

Start: 941533

End: 943791

Strand: Direct

Name: dnaX [H]

Synonym: VS_0915

Alternate gene names: 218708914

Gene position: 941533-943791 (Clockwise)

Preceding gene: 218708913

Following gene: 218708915

Centisome position: 28.54

GC content: 48.07

Gene sequence:

>2259_bases
ATGAGCTATCTTGCGTTAGCGCGAAAATGGCGACCAACCAAATTCAAAGAAGTGGTTGGTCAAGCCCATGTTTTAACAGC
ATTAGAGAATGCCCTTAGCCAAAATAGGTTGCATCACGCTTACCTATTCAGCGGTACACGAGGTGTCGGTAAAACGACCA
TCGGCCGTTTGTTTGCGAAGGGACTCAACTGTGAAACAGGCATTACTTCAACCCCTTGTGGTGAGTGTGCAACCTGTAAA
GAGATCGATGAAGGTCGTTTTGTTGACCTGCTCGAGATCGATGCTGCCTCACGTACTAAGGTAGAAGATACCCGCGAGCT
TCTGGACAATGTTCAGTACAAGCCTGCACGTGGTCGCTTCAAGGTTTACCTAATCGATGAAGTACACATGCTGTCTAGGC
ACAGTTTTAACGCGCTTCTAAAGACCTTAGAAGAGCCGCCTGAGTATGTGAAGTTCTTGCTCGCAACGACCGATCCACAA
AAGCTTCCGGTTACGATTCTTTCACGTTGTTTGCAGTTCCATCTTAAGCCGATCAGTGTCGATAATATCCACGAGCAGCT
CGATCATATTCTTGAACAAGAAAATGTGACATCTGAACCTCGTGCGCTTGGGATGATTGCTCATGCTGCTGATGGCAGTA
TGCGTGATGCGCTAAGCCTGAGTGACCAAGCTATCGCATTGGGTAACGGTAATGTCGTAACAGACACTGTTGCTCATATG
CTTGGAACGCTGGATACAGACCAAGCGATTCACCTACTTGAAGCGATTAGCAGTAAACAGCCTCAGCAAGCGATGGCTTG
TATTCAAGCTCTTGCTGAAAATGGCGTTGAGTGGGATGGATTGCTGAGTCAACTTGCGACTCAATTACACCGTTTGGCGA
TGTATCAAGCTCTGCCGTCTACTTTAGACAAGGCCCAGCCTGATGCTGAAAGGCTGGAACTGATGAGCAAAACGTTAAGC
CCTCAAGACATCCAACTCTACTACCAGATAGTGCTAAAAGGTCGTCAAGACTTGCCATTATCGCCAACTGCTCGTGTTGG
TATTGAGATGGTGGTTCTGCGTATGTTGGCATTTAGGCCTGCTGAGCAAACTGTTGCTACGGCAATCTCGACTCAGTCGA
CAAGCCCAGCGCCAGCTCCTGCAGCTCAGAATCCGGTTCAGAACCAGGTTCAGGGTGTTGCTCAGTCAATGAGTCAACCT
GTGCCAGAGCCGAGACAGCAAGTTCAGGCTCCTGTGGGTTCACAGCCTCAAGTACAGCAACAAGCTCCTGTTCAGCAGCC
TGTGCAACAGCAACAACAGAACCCGGCACAATATTCAGATTCGCAAGGTTACGCTGATCATTCAGGCAACCAAGGTTATC
CAGAACAGGATTACCCGCACAGCCAGTATGATGTACCACCTGCTTATGATGAGCGTCCAAGTTACGGTGCAGATCAGCCT
CAGCAGCAACAAACGAATTATCAGAGCCAGAGTCCGGTTCAACAGCCAAGCGCTGCGCCTTCTACTCCTCCTGTTTCGCA
AGAGCAACCCGCGCGTGCAACTTCACCGGTGAGTGGTTTACGCCACCAATTGCGCTCTCAACGCAGAAGCAGCGCGGCAA
CAGATAACAAAGGCTCAACGCCAAAAAAGGCTAAAGCGACATCAGCTAAAACTTCAGTTCTTGACCGAGTTGCCCAGCAA
CACGGTGGTTCTGAGCGGGTGTCGCCAGCTTCTTTATCAGCCTCTTCTACTGAAAAGGTAACCAATGATAATGAACCTTA
TCGCTGGAAACCGTCTAAACCTGTAGTGAAAGAGGTGAGCAAAGAGCTTACACCTACTCAGATCAAGCGTGCGTTAGAGC
ATATTAAGACACCAGAAATGGTCGATAAATTGCTTCAAGAGTCGATTGCTCAAGATGAATGGTCCGCCACGATTCAAAAG
CTAGAGACAGCCAAGCTTGTTGAACAGTTAGCATTGAACTCAGTGTTTGCTAAAAACGACACATCAATCACTTTAACGTT
AAGAGCGAGCCAAGCTCACTTGAATACGGATCGCGCACAGAGCGAACTATTACAGTCGCTCAATACCGTGTTAGGAGAAG
AGTGTCATTTGAGTGTTGAAATCGGCGAAGGTGGAGAAACGCCACTAGAACTACGAGAAAGATTGTATCAAGGTAAGTTG
AAAGACGCGTTTACCGCTTTGGAAAACGATGCCAACGTACAGTTTATTGAAAGACGTTTTGCTGCAGAACTCGACAGAGA
CAGCGTTCGTCCTATTTAG

Upstream 100 bases:

>100_bases
CCTTCCAGAAATCGGTGGTGATAAGCGCTTACAAGGCTTAGGTCTAGAAGTGTTTAGCATCTGCGAATTCGACGGTCACT
AATCCTTTTCGGAATTATTC

Downstream 100 bases:

>100_bases
AACTTTTTCACGTTTAGTGACCGGCGTATCATCCCAGATAAGCAAATCTGAGAACTGAACACCGAGGGGTTGAATCACAC
TGTTTTAACCCCCATTTAAG

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MSYLALARKWRPTKFKEVVGQAHVLTALENALSQNRLHHAYLFSGTRGVGKTTIGRLFAKGLNCETGITSTPCGECATCK
EIDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPVTILSRCLQFHLKPISVDNIHEQLDHILEQENVTSEPRALGMIAHAADGSMRDALSLSDQAIALGNGNVVTDTVAHM
LGTLDTDQAIHLLEAISSKQPQQAMACIQALAENGVEWDGLLSQLATQLHRLAMYQALPSTLDKAQPDAERLELMSKTLS
PQDIQLYYQIVLKGRQDLPLSPTARVGIEMVVLRMLAFRPAEQTVATAISTQSTSPAPAPAAQNPVQNQVQGVAQSMSQP
VPEPRQQVQAPVGSQPQVQQQAPVQQPVQQQQQNPAQYSDSQGYADHSGNQGYPEQDYPHSQYDVPPAYDERPSYGADQP
QQQQTNYQSQSPVQQPSAAPSTPPVSQEQPARATSPVSGLRHQLRSQRRSSAATDNKGSTPKKAKATSAKTSVLDRVAQQ
HGGSERVSPASLSASSTEKVTNDNEPYRWKPSKPVVKEVSKELTPTQIKRALEHIKTPEMVDKLLQESIAQDEWSATIQK
LETAKLVEQLALNSVFAKNDTSITLTLRASQAHLNTDRAQSELLQSLNTVLGEECHLSVEIGEGGETPLELRERLYQGKL
KDAFTALENDANVQFIERRFAAELDRDSVRPI

Sequences:

>Translated_752_residues
MSYLALARKWRPTKFKEVVGQAHVLTALENALSQNRLHHAYLFSGTRGVGKTTIGRLFAKGLNCETGITSTPCGECATCK
EIDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPVTILSRCLQFHLKPISVDNIHEQLDHILEQENVTSEPRALGMIAHAADGSMRDALSLSDQAIALGNGNVVTDTVAHM
LGTLDTDQAIHLLEAISSKQPQQAMACIQALAENGVEWDGLLSQLATQLHRLAMYQALPSTLDKAQPDAERLELMSKTLS
PQDIQLYYQIVLKGRQDLPLSPTARVGIEMVVLRMLAFRPAEQTVATAISTQSTSPAPAPAAQNPVQNQVQGVAQSMSQP
VPEPRQQVQAPVGSQPQVQQQAPVQQPVQQQQQNPAQYSDSQGYADHSGNQGYPEQDYPHSQYDVPPAYDERPSYGADQP
QQQQTNYQSQSPVQQPSAAPSTPPVSQEQPARATSPVSGLRHQLRSQRRSSAATDNKGSTPKKAKATSAKTSVLDRVAQQ
HGGSERVSPASLSASSTEKVTNDNEPYRWKPSKPVVKEVSKELTPTQIKRALEHIKTPEMVDKLLQESIAQDEWSATIQK
LETAKLVEQLALNSVFAKNDTSITLTLRASQAHLNTDRAQSELLQSLNTVLGEECHLSVEIGEGGETPLELRERLYQGKL
KDAFTALENDANVQFIERRFAAELDRDSVRPI
>Mature_751_residues
SYLALARKWRPTKFKEVVGQAHVLTALENALSQNRLHHAYLFSGTRGVGKTTIGRLFAKGLNCETGITSTPCGECATCKE
IDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQK
LPVTILSRCLQFHLKPISVDNIHEQLDHILEQENVTSEPRALGMIAHAADGSMRDALSLSDQAIALGNGNVVTDTVAHML
GTLDTDQAIHLLEAISSKQPQQAMACIQALAENGVEWDGLLSQLATQLHRLAMYQALPSTLDKAQPDAERLELMSKTLSP
QDIQLYYQIVLKGRQDLPLSPTARVGIEMVVLRMLAFRPAEQTVATAISTQSTSPAPAPAAQNPVQNQVQGVAQSMSQPV
PEPRQQVQAPVGSQPQVQQQAPVQQPVQQQQQNPAQYSDSQGYADHSGNQGYPEQDYPHSQYDVPPAYDERPSYGADQPQ
QQQTNYQSQSPVQQPSAAPSTPPVSQEQPARATSPVSGLRHQLRSQRRSSAATDNKGSTPKKAKATSAKTSVLDRVAQQH
GGSERVSPASLSASSTEKVTNDNEPYRWKPSKPVVKEVSKELTPTQIKRALEHIKTPEMVDKLLQESIAQDEWSATIQKL
ETAKLVEQLALNSVFAKNDTSITLTLRASQAHLNTDRAQSELLQSLNTVLGEECHLSVEIGEGGETPLELRERLYQGKLK
DAFTALENDANVQFIERRFAAELDRDSVRPI

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=301, Percent_Identity=23.9202657807309, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI31881687, Length=301, Percent_Identity=23.9202657807309, Blast_Score=70, Evalue=9e-12,
Organism=Homo sapiens, GI6677723, Length=318, Percent_Identity=22.9559748427673, Blast_Score=68, Evalue=4e-11,
Organism=Homo sapiens, GI194306571, Length=316, Percent_Identity=22.7848101265823, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI194306567, Length=316, Percent_Identity=22.7848101265823, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1786676, Length=507, Percent_Identity=52.6627218934911, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI71986063, Length=312, Percent_Identity=22.7564102564103, Blast_Score=71, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=299, Percent_Identity=25.0836120401338, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6324039, Length=223, Percent_Identity=24.6636771300448, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 82862; Mature: 82731

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLALARKWRPTKFKEVVGQAHVLTALENALSQNRLHHAYLFSGTRGVGKTTIGRLFAK
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCCHHHHHHHHHC
GLNCETGITSTPCGECATCKEIDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRF
CCCCCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPVTILSRCLQFHLKPISV
EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCH
DNIHEQLDHILEQENVTSEPRALGMIAHAADGSMRDALSLSDQAIALGNGNVVTDTVAHM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCHHHHHHHH
LGTLDTDQAIHLLEAISSKQPQQAMACIQALAENGVEWDGLLSQLATQLHRLAMYQALPS
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TLDKAQPDAERLELMSKTLSPQDIQLYYQIVLKGRQDLPLSPTARVGIEMVVLRMLAFRP
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
AEQTVATAISTQSTSPAPAPAAQNPVQNQVQGVAQSMSQPVPEPRQQVQAPVGSQPQVQQ
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHH
QAPVQQPVQQQQQNPAQYSDSQGYADHSGNQGYPEQDYPHSQYDVPPAYDERPSYGADQP
HCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QQQQTNYQSQSPVQQPSAAPSTPPVSQEQPARATSPVSGLRHQLRSQRRSSAATDNKGST
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PKKAKATSAKTSVLDRVAQQHGGSERVSPASLSASSTEKVTNDNEPYRWKPSKPVVKEVS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCEEECCCCHHHHHHH
KELTPTQIKRALEHIKTPEMVDKLLQESIAQDEWSATIQKLETAKLVEQLALNSVFAKND
HCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TSITLTLRASQAHLNTDRAQSELLQSLNTVLGEECHLSVEIGEGGETPLELRERLYQGKL
CEEEEEEECCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCHH
KDAFTALENDANVQFIERRFAAELDRDSVRPI
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SYLALARKWRPTKFKEVVGQAHVLTALENALSQNRLHHAYLFSGTRGVGKTTIGRLFAK
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEECCCCCCCHHHHHHHHHC
GLNCETGITSTPCGECATCKEIDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRF
CCCCCCCCCCCCCCCCCHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPVTILSRCLQFHLKPISV
EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCH
DNIHEQLDHILEQENVTSEPRALGMIAHAADGSMRDALSLSDQAIALGNGNVVTDTVAHM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCHHHHHHHH
LGTLDTDQAIHLLEAISSKQPQQAMACIQALAENGVEWDGLLSQLATQLHRLAMYQALPS
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
TLDKAQPDAERLELMSKTLSPQDIQLYYQIVLKGRQDLPLSPTARVGIEMVVLRMLAFRP
HHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCC
AEQTVATAISTQSTSPAPAPAAQNPVQNQVQGVAQSMSQPVPEPRQQVQAPVGSQPQVQQ
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCHHH
QAPVQQPVQQQQQNPAQYSDSQGYADHSGNQGYPEQDYPHSQYDVPPAYDERPSYGADQP
HCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
QQQQTNYQSQSPVQQPSAAPSTPPVSQEQPARATSPVSGLRHQLRSQRRSSAATDNKGST
HHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PKKAKATSAKTSVLDRVAQQHGGSERVSPASLSASSTEKVTNDNEPYRWKPSKPVVKEVS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCCCEEECCCCHHHHHHH
KELTPTQIKRALEHIKTPEMVDKLLQESIAQDEWSATIQKLETAKLVEQLALNSVFAKND
HCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TSITLTLRASQAHLNTDRAQSELLQSLNTVLGEECHLSVEIGEGGETPLELRERLYQGKL
CEEEEEEECCHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCHH
KDAFTALENDANVQFIERRFAAELDRDSVRPI
HHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]