The gene/protein map for NC_011753 is currently unavailable.
Definition Vibrio splendidus LGP32 chromosome 1, complete genome.
Accession NC_011753
Length 3,299,303

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The map label for this gene is pdxB

Identifier: 218708899

GI number: 218708899

Start: 924183

End: 925316

Strand: Direct

Name: pdxB

Synonym: VS_0900

Alternate gene names: 218708899

Gene position: 924183-925316 (Clockwise)

Preceding gene: 218708898

Following gene: 218708900

Centisome position: 28.01

GC content: 45.59

Gene sequence:

>1134_bases
ATGAAAATCTTAATCGACGAAAATATGCCTTATGCTGAAGCGCTTTTTAGCCAGCTAGGGGAAGTGACAATGAAGTCTGG
TCGCACATTAACGGCTGACGACCTAGTTGACGTAGACGCTTTGATGATTCGCTCTGTCACCAAGGTGAACGAGTCATTGA
TCAGCAAAGCCAACAAGCTGAAGTTTGTCGGCACAGCGACGGCAGGTATGGATCATGTCGACCAAGAATTGATGAAAGAA
CGTGGCATTTTCTTTACTGCAGCTCCAGGCTGTAACAAGGTGGGTGTGGCTGAGTATGCGTTCAGCGCGATGATGGTGTT
GGCTCAGCAGCAAGGTTTCTCTGTATTCGAAAAAACGGTCGGTATTATCGGCTGTGGGCAGGTAGGCAGTTACTTAGCGA
AATGCCTTGAAGGTATTGGTATTAAAGTTCTGCTGAACGATCCTCTAAAACAGCAAGAGGGTGATACTCGCGAATTTACT
GAGCTAGATACTCTGCTTGAGCAGTCAGACGTCATCACTCTGCATACGCCAATCACTAAGACAGGTGAGTTCCCAACGCA
TCATTTGATCAATGAGCAAGTACTGAACAATTTACGTGCTGACCAAATTCTGATTAATGCGGCTCGTGGCCCAGTTGTTG
ATAACCAAGCGTTAAAAGCTCGCTTGCAAAAAGCCGATGGTTTCACTGCCGTTCTTGATGTGTTTGAGTTTGAACCTGAA
GTCGATTTTGAGCTGCTTCCACTGCTTGCTTTTACAACTCCTCACGTAGCGGGCTACGGTTTAGAGGGTAAAGCACGTGG
TACCACGATGATCTTCAACAGTTATTGTGAGTTTTTAGGTACTGAACAGCGTGCTTATGCAAGTGACCTTCTGCCGACAG
CACCAGTGCCTAAAATGAAATTAGATAGAGCTTGGGATGAAGCAACACTGCACAATTTGACTCAGTTGATCTATGATGTG
CGCAAAGACGACGCCTTATTCCGTCGCAATATCTCTACGCCGGGTTCTTTTGACAAGATGCGTAAAGAATATTGGGACCG
CAGAGAGTACAGTGCAGTCGAGTTAACGGGCGACGAATCTTGTAATTTAACGCCGTTATCTAAACTCGGTTTTATGGTAA
AGCCAACTTTATAA

Upstream 100 bases:

>100_bases
ATAATGTATTCCAATTGCTACTCGACACCGTGTGTGGAATTTTGCACAATCATTTCAATTCACATTTAGGTCGATAGACC
CCAACAAAAGTACTCGCCAA

Downstream 100 bases:

>100_bases
AAGAGAGAAACAATGAGCCAAGAATTTAATATTGCTATTTTAGGTGCGACTGGTGCGGTTGGTGAAACCATTCTTGAAGT
ACTTAAAGAGCGTAAATTCC

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKILIDENMPYAEALFSQLGEVTMKSGRTLTADDLVDVDALMIRSVTKVNESLISKANKLKFVGTATAGMDHVDQELMKE
RGIFFTAAPGCNKVGVAEYAFSAMMVLAQQQGFSVFEKTVGIIGCGQVGSYLAKCLEGIGIKVLLNDPLKQQEGDTREFT
ELDTLLEQSDVITLHTPITKTGEFPTHHLINEQVLNNLRADQILINAARGPVVDNQALKARLQKADGFTAVLDVFEFEPE
VDFELLPLLAFTTPHVAGYGLEGKARGTTMIFNSYCEFLGTEQRAYASDLLPTAPVPKMKLDRAWDEATLHNLTQLIYDV
RKDDALFRRNISTPGSFDKMRKEYWDRREYSAVELTGDESCNLTPLSKLGFMVKPTL

Sequences:

>Translated_377_residues
MKILIDENMPYAEALFSQLGEVTMKSGRTLTADDLVDVDALMIRSVTKVNESLISKANKLKFVGTATAGMDHVDQELMKE
RGIFFTAAPGCNKVGVAEYAFSAMMVLAQQQGFSVFEKTVGIIGCGQVGSYLAKCLEGIGIKVLLNDPLKQQEGDTREFT
ELDTLLEQSDVITLHTPITKTGEFPTHHLINEQVLNNLRADQILINAARGPVVDNQALKARLQKADGFTAVLDVFEFEPE
VDFELLPLLAFTTPHVAGYGLEGKARGTTMIFNSYCEFLGTEQRAYASDLLPTAPVPKMKLDRAWDEATLHNLTQLIYDV
RKDDALFRRNISTPGSFDKMRKEYWDRREYSAVELTGDESCNLTPLSKLGFMVKPTL
>Mature_377_residues
MKILIDENMPYAEALFSQLGEVTMKSGRTLTADDLVDVDALMIRSVTKVNESLISKANKLKFVGTATAGMDHVDQELMKE
RGIFFTAAPGCNKVGVAEYAFSAMMVLAQQQGFSVFEKTVGIIGCGQVGSYLAKCLEGIGIKVLLNDPLKQQEGDTREFT
ELDTLLEQSDVITLHTPITKTGEFPTHHLINEQVLNNLRADQILINAARGPVVDNQALKARLQKADGFTAVLDVFEFEPE
VDFELLPLLAFTTPHVAGYGLEGKARGTTMIFNSYCEFLGTEQRAYASDLLPTAPVPKMKLDRAWDEATLHNLTQLIYDV
RKDDALFRRNISTPGSFDKMRKEYWDRREYSAVELTGDESCNLTPLSKLGFMVKPTL

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily

Homologues:

Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=28.5223367697594, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI145580578, Length=256, Percent_Identity=28.125, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4557499, Length=256, Percent_Identity=28.125, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI145580575, Length=256, Percent_Identity=29.296875, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI61743967, Length=256, Percent_Identity=29.6875, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4557497, Length=256, Percent_Identity=29.6875, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788660, Length=371, Percent_Identity=50.1347708894879, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI87082289, Length=242, Percent_Identity=31.8181818181818, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787645, Length=209, Percent_Identity=29.1866028708134, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1789279, Length=256, Percent_Identity=30.078125, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=286, Percent_Identity=29.7202797202797, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=303, Percent_Identity=30.03300330033, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322116, Length=303, Percent_Identity=30.03300330033, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=159, Percent_Identity=29.559748427673, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=25.6317689530686, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921140, Length=272, Percent_Identity=24.6323529411765, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646446, Length=257, Percent_Identity=29.1828793774319, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24646448, Length=257, Percent_Identity=29.1828793774319, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24646452, Length=257, Percent_Identity=29.1828793774319, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24646450, Length=257, Percent_Identity=29.1828793774319, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI62472511, Length=257, Percent_Identity=29.1828793774319, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28574286, Length=238, Percent_Identity=28.9915966386555, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585514, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574282, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28574284, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551003, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45552429, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXB_VIBSL (B7VL81)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416520.1
- GeneID:   7160497
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0900
- HOGENOM:   HBG289972
- OMA:   SAPGCNA
- ProtClustDB:   CLSK874680
- GO:   GO:0005737
- HAMAP:   MF_01825
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF4

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.290

Molecular weight: Translated: 41848; Mature: 41848

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 209-209 ACT_SITE 238-238 ACT_SITE 255-255 BINDING 45-45 BINDING 67-67 BINDING 147-147 BINDING 176-176 BINDING 233-233 BINDING 258-258 BINDING 259-259

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MKILIDENMPYAEALFSQLGEVTMKSGRTLTADDLVDVDALMIRSVTKVNESLISKANKL
CEEEEECCCCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
KFVGTATAGMDHVDQELMKERGIFFTAAPGCNKVGVAEYAFSAMMVLAQQQGFSVFEKTV
EEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
GIIGCGQVGSYLAKCLEGIGIKVLLNDPLKQQEGDTREFTELDTLLEQSDVITLHTPITK
CEEECCHHHHHHHHHHHCCCEEEEECCCHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCC
TGEFPTHHLINEQVLNNLRADQILINAARGPVVDNQALKARLQKADGFTAVLDVFEFEPE
CCCCCHHHHHHHHHHHHCCHHHEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCC
VDFELLPLLAFTTPHVAGYGLEGKARGTTMIFNSYCEFLGTEQRAYASDLLPTAPVPKMK
CCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCH
LDRAWDEATLHNLTQLIYDVRKDDALFRRNISTPGSFDKMRKEYWDRREYSAVELTGDES
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
CNLTPLSKLGFMVKPTL
CCCCCHHHCCEEECCCC
>Mature Secondary Structure
MKILIDENMPYAEALFSQLGEVTMKSGRTLTADDLVDVDALMIRSVTKVNESLISKANKL
CEEEEECCCCHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
KFVGTATAGMDHVDQELMKERGIFFTAAPGCNKVGVAEYAFSAMMVLAQQQGFSVFEKTV
EEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
GIIGCGQVGSYLAKCLEGIGIKVLLNDPLKQQEGDTREFTELDTLLEQSDVITLHTPITK
CEEECCHHHHHHHHHHHCCCEEEEECCCHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCC
TGEFPTHHLINEQVLNNLRADQILINAARGPVVDNQALKARLQKADGFTAVLDVFEFEPE
CCCCCHHHHHHHHHHHHCCHHHEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCC
VDFELLPLLAFTTPHVAGYGLEGKARGTTMIFNSYCEFLGTEQRAYASDLLPTAPVPKMK
CCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCH
LDRAWDEATLHNLTQLIYDVRKDDALFRRNISTPGSFDKMRKEYWDRREYSAVELTGDES
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCC
CNLTPLSKLGFMVKPTL
CCCCCHHHCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA