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The map label for this gene is fabB [H]

Identifier: 218708897

GI number: 218708897

Start: 922441

End: 923652

Strand: Direct

Name: fabB [H]

Synonym: VS_0898

Alternate gene names: 218708897

Gene position: 922441-923652 (Clockwise)

Preceding gene: 218708895

Following gene: 218708898

Centisome position: 27.96

GC content: 47.52

Gene sequence:

>1212_bases
ATGAAACGAGTCGTAATCACCGGTATGGGTATTGTTTCAAGTATCGGTAACAACGTCGAAGAAGTTTTAGCATCACTGAA
AGAGGGTAAATCAGGTATTACCGCTTCAGAGCAGTTCAAGGAAAATGGCTTGCGCTCTCAAGTATGGGGTAACCTAAAAA
TGAACCCTGCTGACCATATCGATCGCAAAAAAATGCGCTTTATGGGTGATGCAGCGGCATTCGCTTATCTTTCAATGGAG
CAAGCAATTGCTGACTCTGGTTTAACTGAAGATCAAGTATCTAATGACCGCACAGGTATCGTTGCGGGTTCAGGTGGTGC
TTCATCTCTAAACCAAGTAAACGCAGTAGACATCATCCGTGAAAAAGGCGTGAAGCGCGTTGGCCCATACATGGTTCCAC
GTACAATGGCTTCTACGGTTTCTGCTTGTCTAGCAACACCTTTCAAAATCCGCGGTGTGAACTACTCTATGAGTTCTGCA
TGTGCAACATCTGCACACTGTATCGGTCACGCAATGGAGCTTATCCAACTTGGTAAGCAAGACGTAGTATTTGCTGGTGG
CGGTGAAGAACTGGATTGGTCTCTGACTATGATGTTCGACGCAATGGGCGCACTTTCTACTAAGTACAACGACACGCCAG
AATTGGCTTCTCGTACTTACGATGCTGACCGTGACGGTTTCGTTATCTCTGGTGGCGGCGGTATGCTAGTTATCGAAGAA
CTTGAGCACGCTGTTGCTCGTGGCGCAAAAATTTACGGTGAGATCGTGGGTTACGGCGCAACTTCAGATGGCTACGACAT
GGTTGCTCCTTCTGGTGAAGGCGCGGTTCGTTGTATGAAGATGGCAATGCAAAACGTTGATGGCGTTGACTACGTGAACA
CTCACGGTACTTCAACTCCTGTAGGTGACGTTAAAGAACTTGGCGCAATCCAAGAAGTCTTTGGCGGCAACAGCCCTGCA
ATCTCAGCAACTAAAGCGATGACAGGTCACGCTCTAGGTGCGGCTGGTGTACACGAAGCAATTTACTCAACGCTAATGCT
TGATAACGGCTTCATCGCACCAAGCATTAACGTTGCAAACCTAGACGAAGCGGGCGAAGGCCTAGACATCGTAACCGAAG
CTCGTGAACAAGAGCTAACAACGGTTATGTCTAACAGCTTTGGTTTCGGCGGTACGAACGCAACGCTAGTAATCAAAAAA
TACCAAGGCTAA

Upstream 100 bases:

>100_bases
ATATGTTGGTAGGGATTGTACGAATTTCTAGGAAAGCTGACCACTTTTGTTAGGCTTCTTAGTTATCATCTAGCTGAATT
TAGAATTATAGGAATGTCAC

Downstream 100 bases:

>100_bases
TTGAAGCTAAGGTTAAATTAATAAAAGGTTAATCGTTAATGGGTGACGTGAGTGCTGATTCAACACGCACAGGTCGCTCA
TTAACCCTGACCAACAGAAC

Product: 3-oxoacyl-[acyl-carrier-protein] synthase I (Beta-ketoacyl-ACP synthase I)

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKRVVITGMGIVSSIGNNVEEVLASLKEGKSGITASEQFKENGLRSQVWGNLKMNPADHIDRKKMRFMGDAAAFAYLSME
QAIADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDIIREKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSA
CATSAHCIGHAMELIQLGKQDVVFAGGGEELDWSLTMMFDAMGALSTKYNDTPELASRTYDADRDGFVISGGGGMLVIEE
LEHAVARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDGVDYVNTHGTSTPVGDVKELGAIQEVFGGNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLDNGFIAPSINVANLDEAGEGLDIVTEAREQELTTVMSNSFGFGGTNATLVIKK
YQG

Sequences:

>Translated_403_residues
MKRVVITGMGIVSSIGNNVEEVLASLKEGKSGITASEQFKENGLRSQVWGNLKMNPADHIDRKKMRFMGDAAAFAYLSME
QAIADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDIIREKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSA
CATSAHCIGHAMELIQLGKQDVVFAGGGEELDWSLTMMFDAMGALSTKYNDTPELASRTYDADRDGFVISGGGGMLVIEE
LEHAVARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDGVDYVNTHGTSTPVGDVKELGAIQEVFGGNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLDNGFIAPSINVANLDEAGEGLDIVTEAREQELTTVMSNSFGFGGTNATLVIKK
YQG
>Mature_403_residues
MKRVVITGMGIVSSIGNNVEEVLASLKEGKSGITASEQFKENGLRSQVWGNLKMNPADHIDRKKMRFMGDAAAFAYLSME
QAIADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDIIREKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSA
CATSAHCIGHAMELIQLGKQDVVFAGGGEELDWSLTMMFDAMGALSTKYNDTPELASRTYDADRDGFVISGGGGMLVIEE
LEHAVARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDGVDYVNTHGTSTPVGDVKELGAIQEVFGGNSPA
ISATKAMTGHALGAAGVHEAIYSTLMLDNGFIAPSINVANLDEAGEGLDIVTEAREQELTTVMSNSFGFGGTNATLVIKK
YQG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=424, Percent_Identity=35.6132075471698, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI223972627, Length=169, Percent_Identity=39.0532544378698, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=24.1784037558685, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=72.5925925925926, Blast_Score=595, Evalue=1e-171,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=41.1192214111922, Blast_Score=263, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=421, Percent_Identity=35.6294536817102, Blast_Score=204, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI71983535, Length=267, Percent_Identity=40.0749063670412, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI17550940, Length=412, Percent_Identity=25, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI212642053, Length=353, Percent_Identity=24.6458923512748, Blast_Score=97, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=445, Percent_Identity=31.2359550561798, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24644341, Length=422, Percent_Identity=39.5734597156398, Blast_Score=268, Evalue=6e-72,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=26.1904761904762, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=26.1904761904762, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24581345, Length=426, Percent_Identity=22.3004694835681, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42318; Mature: 42318

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVITGMGIVSSIGNNVEEVLASLKEGKSGITASEQFKENGLRSQVWGNLKMNPADHI
CCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHCCCCCCCCHHHH
DRKKMRFMGDAAAFAYLSMEQAIADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDIIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHH
EKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSACATSAHCIGHAMELIQLGKQ
HCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVVFAGGGEELDWSLTMMFDAMGALSTKYNDTPELASRTYDADRDGFVISGGGGMLVIEE
CEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHAVARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDGVDYVNTHGTSTP
HHHHHHHCHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCCC
VGDVKELGAIQEVFGGNSPAISATKAMTGHALGAAGVHEAIYSTLMLDNGFIAPSINVAN
CCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
LDEAGEGLDIVTEAREQELTTVMSNSFGFGGTNATLVIKKYQG
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKRVVITGMGIVSSIGNNVEEVLASLKEGKSGITASEQFKENGLRSQVWGNLKMNPADHI
CCEEEEECCHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHCCCCCCCCHHHH
DRKKMRFMGDAAAFAYLSMEQAIADSGLTEDQVSNDRTGIVAGSGGASSLNQVNAVDIIR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHHH
EKGVKRVGPYMVPRTMASTVSACLATPFKIRGVNYSMSSACATSAHCIGHAMELIQLGKQ
HCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVVFAGGGEELDWSLTMMFDAMGALSTKYNDTPELASRTYDADRDGFVISGGGGMLVIEE
CEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCEEEECCCCEEEHHH
LEHAVARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDGVDYVNTHGTSTP
HHHHHHHCHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCCC
VGDVKELGAIQEVFGGNSPAISATKAMTGHALGAAGVHEAIYSTLMLDNGFIAPSINVAN
CCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
LDEAGEGLDIVTEAREQELTTVMSNSFGFGGTNATLVIKKYQG
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]