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The map label for this gene is envZ [H]

Identifier: 218708874

GI number: 218708874

Start: 897562

End: 899007

Strand: Direct

Name: envZ [H]

Synonym: VS_0874

Alternate gene names: 218708874

Gene position: 897562-899007 (Clockwise)

Preceding gene: 218708873

Following gene: 218708875

Centisome position: 27.2

GC content: 45.44

Gene sequence:

>1446_bases
ATGAACTGGTTGAGTCGATTAAAACCAAACTCTTTGGTCGCAAGAACCTTATTGTTGACGTTGTTAGCCGTTGTGATTGC
TCAAGGCATCGCAACGTCTATATGGTATAGCGAATCAAAACACAAAGAGCTGGAAGGAATTCGTTCTGCCTCGTCGAGCA
TGGCGAACATGTTTGCTTCAACGGTGACTTTTTTCCAATCTCTACCCGTTAAATATCGTCATATCGTGCTGGATCAAATA
CGGAATATGGGCGGTACGCGCTTCTTCGTTTCTTTCAATAAAGAGGCTTTGATTGTCGAACCGATCCCCGATACCCGTTT
AAAAACAGCCTCGATTGAAGCGATAGAAAGTGTTTTGAGTAGCAAACTCAATAAAGTGGCGTCAGTGCGGGTAGATTTTT
CTCGACCTGAACACCTTCGCTTGCTTAAAAACGACATCTACTTAAGCGATCTCCCGCGATCTTGGGCACATCATACTTTA
ACGTTAGAACCGCTGAATCCACCCATTCTGGTTGTACAAATCGAATTGACCAGTCACGAATGGGTATACATTGCGGCATT
GTTGCCTGCTCCATATGTGAAACTCGACGATACGATTCTTGGCAGAGAGCAGGTGATCTTCTTAGTTTCTTCAACGCTTA
TTCTGCTGGTTCTAACTTACTTGATGATTCGTCGCCAAGTGCGTCCTCTGAAAAAGTTAGCAAGGGCGGCCAATGAGATG
AGTATGGATATTCAGCAGCCTCCGCTAAACGAAGAAGGGGCGACTGAACTGGTCACCGCAACCCGAGCCTTTAATCGCAT
GCAGCAACGGATTCGTCGCTATGTTGCCGACCGAGAGCACCTTTTTTCTGCGATCTCCCATGACTTAAAGACACCAATAA
CACGTCTAAGATTGCGTGCAGAGTTGTTGGAGAGTGAAGTAAAGAAAGACAAATTCAATAAAGATCTCGATGAGCTCGAG
ATGATGGTCAAAGGTGCTTTGCAAGCGGTAAGAGACACCGATCTACACGAGAATAATGCCATTATTGACCTCAACGAAAT
GGTACTTTCTGTTATTGAATCTCATAACCAGTATCAGACAAAAGTTGAGTTTGAGCCGGTCGTCATTGAGCCACTGGTCG
CGAAACCACTGGCGATTAAGCGTGTACTGACCAACTTAATTGACAACGCGGTTAAGTATGGTTCATCAGCTGTCGTGGAA
GTTAGTGGTGATGAGCTTTGGGTTGTCGTGACTATTCAAGACCGTGGGAATGGCATTCCTGAAGACAAGTTAGAGATGGT
TTTTGAACCCTATTTTAGGCTAGCAACGGATGATCAAGGACACGGACTTGGCCTCGGGATCTGCCGAAATATCCTGCACG
GACACGGTGGAGATCTCATTATTCGCAACTCCTCTCAAGGTGGCTTGGAAGTCAAAGTCTATATCCCAACAGGCTTAGAA
GTGTAG

Upstream 100 bases:

>100_bases
AACCATGCGCGGTAATGGCTACATTCTTGCTGTGCCGGTTCAGTATGAACATTGATAATCAAGTGCTGTTAATGAACACC
TTGCCAATGAAGTATTTCCT

Downstream 100 bases:

>100_bases
TGTAACAATCCTGTTACATTGGGCTTACCTTTTGTTTCAATCTTACCAGTCAGAATAAGTAGACTCTTTAATGAACCGGA
CGTCGAGTCCGCTAAACATG

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNWLSRLKPNSLVARTLLLTLLAVVIAQGIATSIWYSESKHKELEGIRSASSSMANMFASTVTFFQSLPVKYRHIVLDQI
RNMGGTRFFVSFNKEALIVEPIPDTRLKTASIEAIESVLSSKLNKVASVRVDFSRPEHLRLLKNDIYLSDLPRSWAHHTL
TLEPLNPPILVVQIELTSHEWVYIAALLPAPYVKLDDTILGREQVIFLVSSTLILLVLTYLMIRRQVRPLKKLARAANEM
SMDIQQPPLNEEGATELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRLRAELLESEVKKDKFNKDLDELE
MMVKGALQAVRDTDLHENNAIIDLNEMVLSVIESHNQYQTKVEFEPVVIEPLVAKPLAIKRVLTNLIDNAVKYGSSAVVE
VSGDELWVVVTIQDRGNGIPEDKLEMVFEPYFRLATDDQGHGLGLGICRNILHGHGGDLIIRNSSQGGLEVKVYIPTGLE
V

Sequences:

>Translated_481_residues
MNWLSRLKPNSLVARTLLLTLLAVVIAQGIATSIWYSESKHKELEGIRSASSSMANMFASTVTFFQSLPVKYRHIVLDQI
RNMGGTRFFVSFNKEALIVEPIPDTRLKTASIEAIESVLSSKLNKVASVRVDFSRPEHLRLLKNDIYLSDLPRSWAHHTL
TLEPLNPPILVVQIELTSHEWVYIAALLPAPYVKLDDTILGREQVIFLVSSTLILLVLTYLMIRRQVRPLKKLARAANEM
SMDIQQPPLNEEGATELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRLRAELLESEVKKDKFNKDLDELE
MMVKGALQAVRDTDLHENNAIIDLNEMVLSVIESHNQYQTKVEFEPVVIEPLVAKPLAIKRVLTNLIDNAVKYGSSAVVE
VSGDELWVVVTIQDRGNGIPEDKLEMVFEPYFRLATDDQGHGLGLGICRNILHGHGGDLIIRNSSQGGLEVKVYIPTGLE
V
>Mature_481_residues
MNWLSRLKPNSLVARTLLLTLLAVVIAQGIATSIWYSESKHKELEGIRSASSSMANMFASTVTFFQSLPVKYRHIVLDQI
RNMGGTRFFVSFNKEALIVEPIPDTRLKTASIEAIESVLSSKLNKVASVRVDFSRPEHLRLLKNDIYLSDLPRSWAHHTL
TLEPLNPPILVVQIELTSHEWVYIAALLPAPYVKLDDTILGREQVIFLVSSTLILLVLTYLMIRRQVRPLKKLARAANEM
SMDIQQPPLNEEGATELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRLRAELLESEVKKDKFNKDLDELE
MMVKGALQAVRDTDLHENNAIIDLNEMVLSVIESHNQYQTKVEFEPVVIEPLVAKPLAIKRVLTNLIDNAVKYGSSAVVE
VSGDELWVVVTIQDRGNGIPEDKLEMVFEPYFRLATDDQGHGLGLGICRNILHGHGGDLIIRNSSQGGLEVKVYIPTGLE
V

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=320, Percent_Identity=31.5625, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=30, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1787894, Length=310, Percent_Identity=27.0967741935484, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1790861, Length=381, Percent_Identity=24.4094488188976, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=23.489932885906, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=26.027397260274, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=25.4545454545455, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=233, Percent_Identity=26.6094420600858, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=279, Percent_Identity=23.6559139784946, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=118, Percent_Identity=31.3559322033898, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787374, Length=298, Percent_Identity=23.489932885906, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789403, Length=290, Percent_Identity=25.5172413793103, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=26.6375545851528, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54262; Mature: 54262

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLSRLKPNSLVARTLLLTLLAVVIAQGIATSIWYSESKHKELEGIRSASSSMANMFAS
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TVTFFQSLPVKYRHIVLDQIRNMGGTRFFVSFNKEALIVEPIPDTRLKTASIEAIESVLS
HHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHH
SKLNKVASVRVDFSRPEHLRLLKNDIYLSDLPRSWAHHTLTLEPLNPPILVVQIELTSHE
HHHHHHHEEEEECCCCHHHHHHHHCCCHHCCCCCCCCCEEEEECCCCCEEEEEEEECCCC
WVYIAALLPAPYVKLDDTILGREQVIFLVSSTLILLVLTYLMIRRQVRPLKKLARAANEM
EEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMDIQQPPLNEEGATELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRLRA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLESEVKKDKFNKDLDELEMMVKGALQAVRDTDLHENNAIIDLNEMVLSVIESHNQYQT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCCEEE
KVEFEPVVIEPLVAKPLAIKRVLTNLIDNAVKYGSSAVVEVSGDELWVVVTIQDRGNGIP
EEECCCEEECHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEECCCCCCC
EDKLEMVFEPYFRLATDDQGHGLGLGICRNILHGHGGDLIIRNSSQGGLEVKVYIPTGLE
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCC
V
C
>Mature Secondary Structure
MNWLSRLKPNSLVARTLLLTLLAVVIAQGIATSIWYSESKHKELEGIRSASSSMANMFAS
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
TVTFFQSLPVKYRHIVLDQIRNMGGTRFFVSFNKEALIVEPIPDTRLKTASIEAIESVLS
HHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHH
SKLNKVASVRVDFSRPEHLRLLKNDIYLSDLPRSWAHHTLTLEPLNPPILVVQIELTSHE
HHHHHHHEEEEECCCCHHHHHHHHCCCHHCCCCCCCCCEEEEECCCCCEEEEEEEECCCC
WVYIAALLPAPYVKLDDTILGREQVIFLVSSTLILLVLTYLMIRRQVRPLKKLARAANEM
EEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMDIQQPPLNEEGATELVTATRAFNRMQQRIRRYVADREHLFSAISHDLKTPITRLRLRA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELLESEVKKDKFNKDLDELEMMVKGALQAVRDTDLHENNAIIDLNEMVLSVIESHNQYQT
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCCEEE
KVEFEPVVIEPLVAKPLAIKRVLTNLIDNAVKYGSSAVVEVSGDELWVVVTIQDRGNGIP
EEECCCEEECHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEECCCCCCC
EDKLEMVFEPYFRLATDDQGHGLGLGICRNILHGHGGDLIIRNSSQGGLEVKVYIPTGLE
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEECCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]