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The map label for this gene is ccmE

Identifier: 218708854

GI number: 218708854

Start: 873800

End: 874282

Strand: Direct

Name: ccmE

Synonym: VS_0854

Alternate gene names: 218708854

Gene position: 873800-874282 (Clockwise)

Preceding gene: 218708853

Following gene: 218708855

Centisome position: 26.48

GC content: 43.48

Gene sequence:

>483_bases
ATGAACCCAAGACGCAAAAAGAGGCTAGGCATTATCTTAGCGATCTTTTTTGGTATCAGTGCAACTGTTGGATTGATGGT
TTATGCACTTAACCAGAACATGGATCTGTTCTACACGCCAACTGAGCTCGTCAACGGCAAAGATGGTAAAAAACCTGAAG
TGGGTCAACGCTTACGTATTGGTGGCATGGTTGTAGTCGGCTCTGTAAGCCGTGACAATGAATCATTGCGTGTAAGCTTC
GATTTGGCTGATGTAGGCCCTAAAGTGACGATTCTATATGATGGCATCCTTCCTGATCTTTTCCGTGAAGGCCAAGGTAT
TGTTGCTCAAGGTGTCCTTAAGGATGCAACGACAATTGAAGCGTTTGAGGTGTTGGCAAAGCACGATGAAGAATATATGC
CTTCTGAAGTTGCTGAAGCAATGAAGAAAACTCATGAGCCTTTGCAATACACGACTGAACAAAAAGAAGGAAATGCTCAA
TGA

Upstream 100 bases:

>100_bases
TCGTAAGCGTTCGTCGTGGTAAGCAATTATTAAATGAAGTACAAGCTAAGATTGACCGTCAAGCTCGTATTGATGCAGCA
AAAAATATGGAGAACACTCT

Downstream 100 bases:

>100_bases
TAGCCGAGATCGGCCATTTTGCGATGATCCTGTCTTTGGGACTTGCACTGCTGCTAAGCGTGCTCCCACTGTATGGAGCC
GCTCGAAATAACACATTATT

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MNPRRKKRLGIILAIFFGISATVGLMVYALNQNMDLFYTPTELVNGKDGKKPEVGQRLRIGGMVVVGSVSRDNESLRVSF
DLADVGPKVTILYDGILPDLFREGQGIVAQGVLKDATTIEAFEVLAKHDEEYMPSEVAEAMKKTHEPLQYTTEQKEGNAQ

Sequences:

>Translated_160_residues
MNPRRKKRLGIILAIFFGISATVGLMVYALNQNMDLFYTPTELVNGKDGKKPEVGQRLRIGGMVVVGSVSRDNESLRVSF
DLADVGPKVTILYDGILPDLFREGQGIVAQGVLKDATTIEAFEVLAKHDEEYMPSEVAEAMKKTHEPLQYTTEQKEGNAQ
>Mature_160_residues
MNPRRKKRLGIILAIFFGISATVGLMVYALNQNMDLFYTPTELVNGKDGKKPEVGQRLRIGGMVVVGSVSRDNESLRVSF
DLADVGPKVTILYDGILPDLFREGQGIVAQGVLKDATTIEAFEVLAKHDEEYMPSEVAEAMKKTHEPLQYTTEQKEGNAQ

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=147, Percent_Identity=56.4625850340136, Blast_Score=165, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_VIBSL (B7VL36)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416475.1
- ProteinModelPortal:   B7VL36
- SMR:   B7VL36
- GeneID:   7160452
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0854
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- ProtClustDB:   PRK13165
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 17687; Mature: 17687

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: BINDING 128-128

Signals:

None

Transmembrane regions:

HASH(0x1a0ff784)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRRKKRLGIILAIFFGISATVGLMVYALNQNMDLFYTPTELVNGKDGKKPEVGQRLRI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCHHHHCCCCCCCCCCCCEEEE
GGMVVVGSVSRDNESLRVSFDLADVGPKVTILYDGILPDLFREGQGIVAQGVLKDATTIE
CCEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHCCCCEEEHHHHCCCHHHH
AFEVLAKHDEEYMPSEVAEAMKKTHEPLQYTTEQKEGNAQ
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCH
>Mature Secondary Structure
MNPRRKKRLGIILAIFFGISATVGLMVYALNQNMDLFYTPTELVNGKDGKKPEVGQRLRI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCHHHHCCCCCCCCCCCCEEEE
GGMVVVGSVSRDNESLRVSFDLADVGPKVTILYDGILPDLFREGQGIVAQGVLKDATTIE
CCEEEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHCCCCEEEHHHHCCCHHHH
AFEVLAKHDEEYMPSEVAEAMKKTHEPLQYTTEQKEGNAQ
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA