Click here to switch to the map view.

The map label for this gene is tadA [H]

Identifier: 218708682

GI number: 218708682

Start: 687243

End: 687881

Strand: Direct

Name: tadA [H]

Synonym: VS_0661

Alternate gene names: 218708682

Gene position: 687243-687881 (Clockwise)

Preceding gene: 218708681

Following gene: 218708685

Centisome position: 20.83

GC content: 45.54

Gene sequence:

>639_bases
ATGCTTCACCGCATACCTATTTTCGTTTTTATCCTTTGTTTTCTGGAGCTCCCTTTGTCAGACCATCAATTCAGCCCTCA
AGATGAAATCTTCATGCGACGCGCCATCGAGGTAGCTAAGCAAGCAGAAAAAGAGGGAGAGGTTCCCGTTGGTGCTGTTC
TAGTGAAAGATGGGGAGGTTATCTCTGAAGGATGGAACCGCTCGATTGGCTGCCACGATGCAACCGCACATGCAGAAATC
GAAACCTTGCGTAAAGCAGGTCAAGCCTTGGAAAACTATCGCTTACTTGATACCACCTTGTATGTCACCTTAGAACCGTG
CCCAATGTGCGCGGGTGCCTTATTACACAGCCGAGTAAAGCGCATTGTGTTTGGTGCTCCAGACTTAAAAGCGGGTGCGG
CGGGTACGGTATTGAATCTCTTTGAAAGCCAAGCCTCATACCACTATGCCGATGTTGAGCATGGTTTGTTAGAGGAAGAG
TGTCGTGAACAATTACAGGCGTTTTTTAAACGTCGTAGAAAAGAGATAAAAGAGAAGCGAAATCAAGAACGTCTGTTGGA
AGAGCAGCGTTTAGAATCCGATAAGGCAAGTAATAAGAATAAGGTCAGTAACAAGAACAAGGTCAGTAACAAAAAATAG

Upstream 100 bases:

>100_bases
GACATAGAAGGCGCCAATAGCTAGCGATCCGCCTAATCAGTAAGCGGCGATTGTTCATTGCCTCTTATCTCTTTATTGTT
CATTATCACGAAGATTAGGT

Downstream 100 bases:

>100_bases
CAGCGAGCTTTCGGCACTCTCAATCATAAGAGTGCCAAGCAAACTTACTTGGTCATTACTTTTACTCAGCAATCATCTGC
ATGAAAGCACGGTTGCGCCA

Product: tRNA-specific adenosine deaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MLHRIPIFVFILCFLELPLSDHQFSPQDEIFMRRAIEVAKQAEKEGEVPVGAVLVKDGEVISEGWNRSIGCHDATAHAEI
ETLRKAGQALENYRLLDTTLYVTLEPCPMCAGALLHSRVKRIVFGAPDLKAGAAGTVLNLFESQASYHYADVEHGLLEEE
CREQLQAFFKRRRKEIKEKRNQERLLEEQRLESDKASNKNKVSNKNKVSNKK

Sequences:

>Translated_212_residues
MLHRIPIFVFILCFLELPLSDHQFSPQDEIFMRRAIEVAKQAEKEGEVPVGAVLVKDGEVISEGWNRSIGCHDATAHAEI
ETLRKAGQALENYRLLDTTLYVTLEPCPMCAGALLHSRVKRIVFGAPDLKAGAAGTVLNLFESQASYHYADVEHGLLEEE
CREQLQAFFKRRRKEIKEKRNQERLLEEQRLESDKASNKNKVSNKNKVSNKK
>Mature_212_residues
MLHRIPIFVFILCFLELPLSDHQFSPQDEIFMRRAIEVAKQAEKEGEVPVGAVLVKDGEVISEGWNRSIGCHDATAHAEI
ETLRKAGQALENYRLLDTTLYVTLEPCPMCAGALLHSRVKRIVFGAPDLKAGAAGTVLNLFESQASYHYADVEHGLLEEE
CREQLQAFFKRRRKEIKEKRNQERLLEEQRLESDKASNKNKVSNKNKVSNKK

Specific function: Deaminates adenosine-34 to inosine in tRNA-Arg2 [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI124107608, Length=154, Percent_Identity=32.4675324675325, Blast_Score=78, Evalue=6e-15,
Organism=Escherichia coli, GI145693172, Length=165, Percent_Identity=52.1212121212121, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1786616, Length=155, Percent_Identity=36.1290322580645, Blast_Score=78, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17554608, Length=106, Percent_Identity=44.3396226415094, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17541138, Length=160, Percent_Identity=33.125, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17555996, Length=109, Percent_Identity=34.8623853211009, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6325319, Length=103, Percent_Identity=43.6893203883495, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6322425, Length=175, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: NA

Molecular weight: Translated: 24117; Mature: 24117

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHRIPIFVFILCFLELPLSDHQFSPQDEIFMRRAIEVAKQAEKEGEVPVGAVLVKDGEV
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHH
ISEGWNRSIGCHDATAHAEIETLRKAGQALENYRLLDTTLYVTLEPCPMCAGALLHSRVK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHH
RIVFGAPDLKAGAAGTVLNLFESQASYHYADVEHGLLEEECREQLQAFFKRRRKEIKEKR
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQERLLEEQRLESDKASNKNKVSNKNKVSNKK
HHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCC
>Mature Secondary Structure
MLHRIPIFVFILCFLELPLSDHQFSPQDEIFMRRAIEVAKQAEKEGEVPVGAVLVKDGEV
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHH
ISEGWNRSIGCHDATAHAEIETLRKAGQALENYRLLDTTLYVTLEPCPMCAGALLHSRVK
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHH
RIVFGAPDLKAGAAGTVLNLFESQASYHYADVEHGLLEEECREQLQAFFKRRRKEIKEKR
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQERLLEEQRLESDKASNKNKVSNKNKVSNKK
HHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]