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The map label for this gene is ndk

Identifier: 218708637

GI number: 218708637

Start: 637340

End: 637774

Strand: Direct

Name: ndk

Synonym: VS_0615

Alternate gene names: 218708637

Gene position: 637340-637774 (Clockwise)

Preceding gene: 218708636

Following gene: 218708638

Centisome position: 19.32

GC content: 45.75

Gene sequence:

>435_bases
ATGGCTCTAGAAAGAACGTTCTCAATTGTTAAGCCGGATGCAGTTAAGCGTAACCTTGTCGGTGAAATCTACCACCGCAT
TGAAAAAGCTGGCCTACAGATTATTGCCGCTAAAATGGTTTCTCTTACAGAAGCGCAAGCAAGTGGCTTCTATGCAGAAC
ATGAAGGTAAAGAGTTCTTTGGACCACTAAAAGAGTTCATGACTTCTGGTCCTATCATGGTTCAAGTACTTGAAGGCGAA
AATGCGATCGCTCGTTACCGTGAACTAATGGGTAAAACTAACCCAGAAGAAGCTGCATGCGGCACTATCCGTGCTGACTA
CGCAATCAGCATGCGTTACAACTCAGTACACGGCAGTGATAGCCCTGAATCTGCGGCTCGCGAAATCGAATTCTTCTTCC
CAGAATCTGAAATTTGCCCGCGTCCAGCTGAATAA

Upstream 100 bases:

>100_bases
GAGTGAGCGGTATTTCGATACCGCTTATTCATAAACTCAGATCGAATGATCTTAGTAATTTCAGTATTTAATAACAAAAA
AATGAAGTGAAGGAATCCCT

Downstream 100 bases:

>100_bases
GCAGACAACAGCAAGTCTCAATAAAGGCTTCACTTCGGTGAAGCCTTTTTCATTTCTGGTGAGTTCTCGTGTCATTCCTG
AGAGTGAAGAAGGAGCATAT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MALERTFSIVKPDAVKRNLVGEIYHRIEKAGLQIIAAKMVSLTEAQASGFYAEHEGKEFFGPLKEFMTSGPIMVQVLEGE
NAIARYRELMGKTNPEEAACGTIRADYAISMRYNSVHGSDSPESAAREIEFFFPESEICPRPAE

Sequences:

>Translated_144_residues
MALERTFSIVKPDAVKRNLVGEIYHRIEKAGLQIIAAKMVSLTEAQASGFYAEHEGKEFFGPLKEFMTSGPIMVQVLEGE
NAIARYRELMGKTNPEEAACGTIRADYAISMRYNSVHGSDSPESAAREIEFFFPESEICPRPAE
>Mature_143_residues
ALERTFSIVKPDAVKRNLVGEIYHRIEKAGLQIIAAKMVSLTEAQASGFYAEHEGKEFFGPLKEFMTSGPIMVQVLEGEN
AIARYRELMGKTNPEEAACGTIRADYAISMRYNSVHGSDSPESAAREIEFFFPESEICPRPAE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=137, Percent_Identity=45.2554744525547, Blast_Score=124, Evalue=3e-29,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=41.1764705882353, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=41.1764705882353, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=41.1764705882353, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=41.1764705882353, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=41.1764705882353, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=40.7407407407407, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=40.7407407407407, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=39.7058823529412, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=38.8489208633094, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=38.8489208633094, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI5031951, Length=138, Percent_Identity=37.6811594202899, Blast_Score=93, Evalue=8e-20,
Organism=Homo sapiens, GI4505413, Length=143, Percent_Identity=36.3636363636364, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI30023828, Length=146, Percent_Identity=34.9315068493151, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=34.0579710144928, Blast_Score=81, Evalue=4e-16,
Organism=Escherichia coli, GI1788866, Length=141, Percent_Identity=63.1205673758865, Blast_Score=192, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=41.4814814814815, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=45.5882352941176, Blast_Score=128, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=41.1764705882353, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=36.7647058823529, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_VIBSL (B7VJT4)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416258.1
- ProteinModelPortal:   B7VJT4
- SMR:   B7VJT4
- GeneID:   7160235
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0615
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16021; Mature: 15890

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALERTFSIVKPDAVKRNLVGEIYHRIEKAGLQIIAAKMVSLTEAQASGFYAEHEGKEFF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GPLKEFMTSGPIMVQVLEGENAIARYRELMGKTNPEEAACGTIRADYAISMRYNSVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHCCCEECCEEEEEEECCCCCCC
SPESAAREIEFFFPESEICPRPAE
CHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure 
ALERTFSIVKPDAVKRNLVGEIYHRIEKAGLQIIAAKMVSLTEAQASGFYAEHEGKEFF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
GPLKEFMTSGPIMVQVLEGENAIARYRELMGKTNPEEAACGTIRADYAISMRYNSVHGSD
HHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHCCCEECCEEEEEEECCCCCCC
SPESAAREIEFFFPESEICPRPAE
CHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA