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The map label for this gene is pepB

Identifier: 218708636

GI number: 218708636

Start: 635938

End: 637233

Strand: Direct

Name: pepB

Synonym: VS_0614

Alternate gene names: 218708636

Gene position: 635938-637233 (Clockwise)

Preceding gene: 218708635

Following gene: 218708637

Centisome position: 19.27

GC content: 47.99

Gene sequence:

>1296_bases
ATGTCTACACAGATGTCAGTATTTTTAAGTCAAGAAGCTGCCCAGCCTCAGTGGGGAGCAAGAGCTATTTTATCGTTTTC
AGAAGCGGGAGCGACAATTCACATTGGTGAAGGCCACGATCTAGGCGCAGTTCAACGTGCAGGTCGTACGCTTGACGGAC
AAGGTATCGCATTGGTTGCACTTAGCGGTAAAGGCTGGGATCTAGAAAGTGTTTGGGCTTTTTACCAAGGCTACCGTGGA
CCAAAGAAAAAGAATGCATTGGAGTGGGATGCTCTAGCTGAAGCTGATCAAGTTGAATTGGAAGCACGTATCCGCGCGAC
AGATTGGACGCGTGACATCATCAACAAAACGGCTGAAGAAGTTGCCCCTCGTCAATTAGCGACAATGGCAGCTGAATACA
TCAAGTCAGTGGCACCAGCAGGCACTGTTAAAGCGAAAATCGTTAAAGACAAAGATCTCCTAACTGAAGGTTGGGAAGGC
ATCTATGCGGTAGGCCGCGGCTCTGAACGTACTTCTGCAATGCTTCAACTGGACTTCAACCCTACCGGCGATGAAAACGC
ACCCGTGTTTGCTTGTCTTGTGGGTAAAGGTATCACTTTCGACTCAGGCGGTTACAGCATTAAGCCAGGTCAATTCATGA
CAGCAATGAAGGCTGACATGGGTGGCGCCGCGACTATTACCGGTGGTTTAGGTCTTGCGATTGAACGTGGCCTGAACAAG
CGCATCAAGCTTATCTTATGTTGTGCAGAGAATATGATCTCTGGTCGTGCATTGAAGCTTGGCGACATCATTACTTACAA
AAATGGTAAGACTGTCGAGATCATGAATACCGATGCGGAAGGTCGTTTAGTTTTGGCTGATGGCCTGATGTTCGCAAGCG
CTCAGAATCCTGAGTTGATCATCGACTGTGCAACGCTAACTGGCGCGGCTAAAAATGCATTAGGTAACGACTACCACGCA
TTATTGAGCTTTGATGATGAGTTGTCTCATCAAGCACTAACGGCTGCGAACCAAGAGAAAGAAGGTCTATGGCCATTGCC
GCTTGCTGATTTCCACCGTGGTATGTTGCCTTCAAACTTTGCTGATCTTTCAAACATCAGCTCTGGTGATTACACTCCGG
GTGCAAGTACAGCTGCCGCGTTCCTTTCTTACTTTGTAGATGACTACAAAAAAGGTTGGATTCACATGGATTGCGCGGGT
ACTTACCGCAAGTCATCAAGTGATAAGTGGGCTGCAGGCGCGACCGGTATGGGTGTTCGTACACTGGCTCGTCTTCTTAT
CGACCAAGCAAAATAA

Upstream 100 bases:

>100_bases
ATCAAAATGACATTTTCCTCCTACATAATGCTAACATCAGTGCGCTAATAAAAAACAATCAGAATCACATACTCAAAGTG
GTTCATGACAAGGAGAAATC

Downstream 100 bases:

>100_bases
TAATAAGAGTGAGCGGTATTTCGATACCGCTTATTCATAAACTCAGATCGAATGATCTTAGTAATTTCAGTATTTAATAA
CAAAAAAATGAAGTGAAGGA

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSTQMSVFLSQEAAQPQWGARAILSFSEAGATIHIGEGHDLGAVQRAGRTLDGQGIALVALSGKGWDLESVWAFYQGYRG
PKKKNALEWDALAEADQVELEARIRATDWTRDIINKTAEEVAPRQLATMAAEYIKSVAPAGTVKAKIVKDKDLLTEGWEG
IYAVGRGSERTSAMLQLDFNPTGDENAPVFACLVGKGITFDSGGYSIKPGQFMTAMKADMGGAATITGGLGLAIERGLNK
RIKLILCCAENMISGRALKLGDIITYKNGKTVEIMNTDAEGRLVLADGLMFASAQNPELIIDCATLTGAAKNALGNDYHA
LLSFDDELSHQALTAANQEKEGLWPLPLADFHRGMLPSNFADLSNISSGDYTPGASTAAAFLSYFVDDYKKGWIHMDCAG
TYRKSSSDKWAAGATGMGVRTLARLLIDQAK

Sequences:

>Translated_431_residues
MSTQMSVFLSQEAAQPQWGARAILSFSEAGATIHIGEGHDLGAVQRAGRTLDGQGIALVALSGKGWDLESVWAFYQGYRG
PKKKNALEWDALAEADQVELEARIRATDWTRDIINKTAEEVAPRQLATMAAEYIKSVAPAGTVKAKIVKDKDLLTEGWEG
IYAVGRGSERTSAMLQLDFNPTGDENAPVFACLVGKGITFDSGGYSIKPGQFMTAMKADMGGAATITGGLGLAIERGLNK
RIKLILCCAENMISGRALKLGDIITYKNGKTVEIMNTDAEGRLVLADGLMFASAQNPELIIDCATLTGAAKNALGNDYHA
LLSFDDELSHQALTAANQEKEGLWPLPLADFHRGMLPSNFADLSNISSGDYTPGASTAAAFLSYFVDDYKKGWIHMDCAG
TYRKSSSDKWAAGATGMGVRTLARLLIDQAK
>Mature_430_residues
STQMSVFLSQEAAQPQWGARAILSFSEAGATIHIGEGHDLGAVQRAGRTLDGQGIALVALSGKGWDLESVWAFYQGYRGP
KKKNALEWDALAEADQVELEARIRATDWTRDIINKTAEEVAPRQLATMAAEYIKSVAPAGTVKAKIVKDKDLLTEGWEGI
YAVGRGSERTSAMLQLDFNPTGDENAPVFACLVGKGITFDSGGYSIKPGQFMTAMKADMGGAATITGGLGLAIERGLNKR
IKLILCCAENMISGRALKLGDIITYKNGKTVEIMNTDAEGRLVLADGLMFASAQNPELIIDCATLTGAAKNALGNDYHAL
LSFDDELSHQALTAANQEKEGLWPLPLADFHRGMLPSNFADLSNISSGDYTPGASTAAAFLSYFVDDYKKGWIHMDCAGT
YRKSSSDKWAAGATGMGVRTLARLLIDQAK

Specific function: Probably plays an important role in intracellular peptide degradation

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=321, Percent_Identity=37.3831775700935, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI47155554, Length=350, Percent_Identity=33.1428571428571, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI87082123, Length=426, Percent_Identity=59.3896713615024, Blast_Score=526, Evalue=1e-151,
Organism=Escherichia coli, GI1790710, Length=290, Percent_Identity=42.0689655172414, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17556903, Length=315, Percent_Identity=33.015873015873, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17565172, Length=328, Percent_Identity=29.8780487804878, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI221379063, Length=351, Percent_Identity=32.1937321937322, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI221379062, Length=351, Percent_Identity=32.1937321937322, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI21357381, Length=351, Percent_Identity=32.1937321937322, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24661038, Length=376, Percent_Identity=28.9893617021277, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI21355725, Length=376, Percent_Identity=29.2553191489362, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24662227, Length=337, Percent_Identity=27.893175074184, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI20129969, Length=373, Percent_Identity=28.1501340482574, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI161077148, Length=408, Percent_Identity=26.2254901960784, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20130057, Length=408, Percent_Identity=26.2254901960784, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21355645, Length=346, Percent_Identity=25.7225433526012, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24662223, Length=346, Percent_Identity=25.7225433526012, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI19922386, Length=341, Percent_Identity=26.9794721407625, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI20129963, Length=410, Percent_Identity=26.0975609756098, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24646701, Length=233, Percent_Identity=27.8969957081545, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646703, Length=233, Percent_Identity=27.8969957081545, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21358201, Length=233, Percent_Identity=27.8969957081545, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPB_VIBSL (B7VJT3)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416257.1
- ProteinModelPortal:   B7VJT3
- SMR:   B7VJT3
- MEROPS:   M17.004
- GeneID:   7160234
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0614
- HOGENOM:   HBG742580
- OMA:   MLQLDYN
- ProtClustDB:   PRK05015
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00504
- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819
- PANTHER:   PTHR11963:SF3
- PIRSF:   PIRSF036388
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17

EC number: =3.4.11.23

Molecular weight: Translated: 46145; Mature: 46014

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 208-208 ACT_SITE 282-282

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQMSVFLSQEAAQPQWGARAILSFSEAGATIHIGEGHDLGAVQRAGRTLDGQGIALVA
CCCCEEEEEEHHCCCCCCCHHHHEEHHCCCCEEEECCCCCCHHHHHCCCCCCCCCEEEEE
LSGKGWDLESVWAFYQGYRGPKKKNALEWDALAEADQVELEARIRATDWTRDIINKTAEE
ECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEEEECHHHHHHHHHHHHH
VAPRQLATMAAEYIKSVAPAGTVKAKIVKDKDLLTEGWEGIYAVGRGSERTSAMLQLDFN
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCEEEECCCCCCCEEEEEEECC
PTGDENAPVFACLVGKGITFDSGGYSIKPGQFMTAMKADMGGAATITGGLGLAIERGLNK
CCCCCCCCEEEEEECCCEEECCCCCEECCCHHHHHHHHCCCCCEEEECCCHHHHHHCCCC
RIKLILCCAENMISGRALKLGDIITYKNGKTVEIMNTDAEGRLVLADGLMFASAQNPELI
EEEEEEEECHHHCCCCEEEECCEEEECCCCEEEEEECCCCCEEEEECCEEEECCCCCCEE
IDCATLTGAAKNALGNDYHALLSFDDELSHQALTAANQEKEGLWPLPLADFHRGMLPSNF
EEEEHHCCHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCC
ADLSNISSGDYTPGASTAAAFLSYFVDDYKKGWIHMDCAGTYRKSSSDKWAAGATGMGVR
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCHH
TLARLLIDQAK
HHHHHHHHCCC
>Mature Secondary Structure 
STQMSVFLSQEAAQPQWGARAILSFSEAGATIHIGEGHDLGAVQRAGRTLDGQGIALVA
CCCEEEEEEHHCCCCCCCHHHHEEHHCCCCEEEECCCCCCHHHHHCCCCCCCCCEEEEE
LSGKGWDLESVWAFYQGYRGPKKKNALEWDALAEADQVELEARIRATDWTRDIINKTAEE
ECCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEEEECHHHHHHHHHHHHH
VAPRQLATMAAEYIKSVAPAGTVKAKIVKDKDLLTEGWEGIYAVGRGSERTSAMLQLDFN
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCEEEECCCCCCCEEEEEEECC
PTGDENAPVFACLVGKGITFDSGGYSIKPGQFMTAMKADMGGAATITGGLGLAIERGLNK
CCCCCCCCEEEEEECCCEEECCCCCEECCCHHHHHHHHCCCCCEEEECCCHHHHHHCCCC
RIKLILCCAENMISGRALKLGDIITYKNGKTVEIMNTDAEGRLVLADGLMFASAQNPELI
EEEEEEEECHHHCCCCEEEECCEEEECCCCEEEEEECCCCCEEEEECCEEEECCCCCCEE
IDCATLTGAAKNALGNDYHALLSFDDELSHQALTAANQEKEGLWPLPLADFHRGMLPSNF
EEEEHHCCHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCC
ADLSNISSGDYTPGASTAAAFLSYFVDDYKKGWIHMDCAGTYRKSSSDKWAAGATGMGVR
HHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCHH
TLARLLIDQAK
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA