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The map label for this gene is trpR

Identifier: 218708587

GI number: 218708587

Start: 577704

End: 578000

Strand: Direct

Name: trpR

Synonym: VS_0553

Alternate gene names: 218708587

Gene position: 577704-578000 (Clockwise)

Preceding gene: 218708586

Following gene: 218708594

Centisome position: 17.51

GC content: 44.44

Gene sequence:

>297_bases
ATGGCATCACAACCTGAATATGAGAATTGGCAACAACTGATGGACTTGGTAAAGACGGCTGTCGAAAAAGATCAGCATGA
ACTATTGTTGACCATGATGATGACACCAGACGAGCGAGATGCTTTAGTTGCTCGAATTAACATCTTTTGTGAGTTGATGA
AAGGTGAGATGTCTCAACGACAGGTTAGCCAAATGCTGGGAGTAGGCGTCGCGACGATAACCAGAGGCTCAAATGAGCTA
AAGGCCAAATCTGAACAAGAGAAAGCCGTGATCGCCGACCTTTTGCTCAAACAATAA

Upstream 100 bases:

>100_bases
TTTACATTGGATCACATCAAGTGTTTCGGTATAAAGTGTTCGACGCTTTCAATCGTTAAGCGACTCTTTAAAGTCAGAAT
TTAAAAGTAAGTGTAGAGAT

Downstream 100 bases:

>100_bases
CTGAGTTAAGCAACCTCTGAGTAGTGTGTCTATTAATTCGATAAAAACGCTAACTGAATGTTAGCGTTTTTTAATTCTGG
TGATTGTTCTCTGAGGCTTT

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 98; Mature: 97

Protein sequence:

>98_residues
MASQPEYENWQQLMDLVKTAVEKDQHELLLTMMMTPDERDALVARINIFCELMKGEMSQRQVSQMLGVGVATITRGSNEL
KAKSEQEKAVIADLLLKQ

Sequences:

>Translated_98_residues
MASQPEYENWQQLMDLVKTAVEKDQHELLLTMMMTPDERDALVARINIFCELMKGEMSQRQVSQMLGVGVATITRGSNEL
KAKSEQEKAVIADLLLKQ
>Mature_97_residues
ASQPEYENWQQLMDLVKTAVEKDQHELLLTMMMTPDERDALVARINIFCELMKGEMSQRQVSQMLGVGVATITRGSNELK
AKSEQEKAVIADLLLKQ

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family

Homologues:

Organism=Escherichia coli, GI1790854, Length=97, Percent_Identity=48.4536082474227, Blast_Score=83, Evalue=3e-18,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): TRPR_VIBSL (B7VJN4)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416208.1
- ProteinModelPortal:   B7VJN4
- SMR:   B7VJN4
- GeneID:   7160185
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0553
- HOGENOM:   HBG677773
- OMA:   ELMRGEM
- ProtClustDB:   PRK01381
- GO:   GO:0005737
- HAMAP:   MF_00475
- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1270.10
- PIRSF:   PIRSF003196
- ProDom:   PD012582
- TIGRFAMs:   TIGR01321

Pfam domain/function: PF01371 Trp_repressor; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 11125; Mature: 10994

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
8.2 %Met     (Translated Protein)
9.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
7.2 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASQPEYENWQQLMDLVKTAVEKDQHELLLTMMMTPDERDALVARINIFCELMKGEMSQR
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHH
QVSQMLGVGVATITRGSNELKAKSEQEKAVIADLLLKQ
HHHHHHHCHHHHHCCCCCHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASQPEYENWQQLMDLVKTAVEKDQHELLLTMMMTPDERDALVARINIFCELMKGEMSQR
CCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCHHHHH
QVSQMLGVGVATITRGSNELKAKSEQEKAVIADLLLKQ
HHHHHHHCHHHHHCCCCCHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA