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The map label for this gene is fkpB [H]

Identifier: 218708572

GI number: 218708572

Start: 559458

End: 559889

Strand: Direct

Name: fkpB [H]

Synonym: VS_0538

Alternate gene names: 218708572

Gene position: 559458-559889 (Clockwise)

Preceding gene: 218708571

Following gene: 218708573

Centisome position: 16.96

GC content: 42.59

Gene sequence:

>432_bases
GTGGCAGCAATTAAAAATGATTCAGCAGTAACTCTACATTTTACGATTAAAATGAAGGATGGTTCAGTTGCCGATAGCAC
CGAAAATATGGGTAAGCCTGCGAAGTTCGTTATGGGTGATGGCAGCCTAAGTGAGAACTTTGAACAGTGCTTGATTGGTC
TTGAAACGGGGACTGAAAAGTCTATCGAATTGAAGGCGCAAGACGCGTTTGGTATGCCAAATCCAGATCACATTCATCAT
ATGGATCGTGCTAAATTTGTTGGCGATTCTGAAGTCGAAGTTGGCACTATTATGGCTTTTTCTGGTCCTGATGGTATGGA
AATTCCAGGTATTATCACTGAGATCGCGGGTGATTCAGTGACGGTTGATTTTAATCATCCATTAGCAGGCCAAGACGTTA
CGTTTGACGTTAACATCTTAGCGGTGGACTAA

Upstream 100 bases:

>100_bases
CTGTCGGTTGATTCCGGCGGGGCTTTTTTTTATGCTTCAGTCAACAAGGAAGCAAAGCACAGCGCATCCTCAAATAATAA
AGAAATCTAAGGAAAGTAAC

Downstream 100 bases:

>100_bases
CTATTTTAGCGGTGAACTAACTACCTTAGCGTTAGAATAGCTATCTTAACGTTAGAATAGTTATCTTAACGGTTGAATAA
CATCACCTTACAGCTGTGAT

Product: FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MAAIKNDSAVTLHFTIKMKDGSVADSTENMGKPAKFVMGDGSLSENFEQCLIGLETGTEKSIELKAQDAFGMPNPDHIHH
MDRAKFVGDSEVEVGTIMAFSGPDGMEIPGIITEIAGDSVTVDFNHPLAGQDVTFDVNILAVD

Sequences:

>Translated_143_residues
MAAIKNDSAVTLHFTIKMKDGSVADSTENMGKPAKFVMGDGSLSENFEQCLIGLETGTEKSIELKAQDAFGMPNPDHIHH
MDRAKFVGDSEVEVGTIMAFSGPDGMEIPGIITEIAGDSVTVDFNHPLAGQDVTFDVNILAVD
>Mature_142_residues
AAIKNDSAVTLHFTIKMKDGSVADSTENMGKPAKFVMGDGSLSENFEQCLIGLETGTEKSIELKAQDAFGMPNPDHIHHM
DRAKFVGDSEVEVGTIMAFSGPDGMEIPGIITEIAGDSVTVDFNHPLAGQDVTFDVNILAVD

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=141, Percent_Identity=51.7730496453901, Blast_Score=157, Evalue=2e-40,
Organism=Escherichia coli, GI1789748, Length=139, Percent_Identity=30.2158273381295, Blast_Score=70, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15242; Mature: 15111

Theoretical pI: Translated: 4.15; Mature: 4.15

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIKNDSAVTLHFTIKMKDGSVADSTENMGKPAKFVMGDGSLSENFEQCLIGLETGTEK
CCEECCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHEEEECCCCCCC
SIELKAQDAFGMPNPDHIHHMDRAKFVGDSEVEVGTIMAFSGPDGMEIPGIITEIAGDSV
EEEEEECCCCCCCCCCCCCCCCHHEECCCCCCEEEEEEEECCCCCCCCCCEEEECCCCEE
TVDFNHPLAGQDVTFDVNILAVD
EEEECCCCCCCCEEEEEEEEEEC
>Mature Secondary Structure 
AAIKNDSAVTLHFTIKMKDGSVADSTENMGKPAKFVMGDGSLSENFEQCLIGLETGTEK
CEECCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHHEEEECCCCCCC
SIELKAQDAFGMPNPDHIHHMDRAKFVGDSEVEVGTIMAFSGPDGMEIPGIITEIAGDSV
EEEEEECCCCCCCCCCCCCCCCHHEECCCCCCEEEEEEEECCCCCCCCCCEEEECCCCEE
TVDFNHPLAGQDVTFDVNILAVD
EEEECCCCCCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]