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The map label for this gene is dsbC [H]

Identifier: 218708547

GI number: 218708547

Start: 531761

End: 532540

Strand: Direct

Name: dsbC [H]

Synonym: VS_0513

Alternate gene names: 218708547

Gene position: 531761-532540 (Clockwise)

Preceding gene: 218708546

Following gene: 218708548

Centisome position: 16.12

GC content: 45.77

Gene sequence:

>780_bases
ATGAGCGTATTACGCCGTCTTCCTCTACTAGCGCTTCCTCTCATGATTACTGCATGTAATGCATCAGAAGCGAAAGTAGA
AACAACATCAACAGCCGTAGAAGCTGCTCCAGCTCAAGCTATTGATACAGCTGCGTTAACTAAGCGTTTTGAAAAAATCG
GTATTAAGGTCGATAAGATTGTTCCTTCGGATATCGATGGTCTTTTAGAAGTTCAAACCAACAGCGGTATTATCTTTTCT
TCTCCAGAGGGCGATCACTTTCTAGCCGGTACACTTTACTCTTTGGATGAAAACGGTAAGTTCAGTGATGTTTTGGCTGA
GCGTCAAGCTCCACTGAATGCTGAGAAAGTTGCAGCGATGTCGGATACGGTTATCGAATATAAAGCAGATAACGAAAAGT
ACGTTGTGACGGTATTTACTGACATTACGTGTGGCTACTGTGTTCGTCTGCACAGCCAAATGCAAGGCTACAACGATCTG
GGTATCACCGTTCGTTACATGGCTTACCCACGCCAAGGTGCGACAGGACAAGTTGCCGATCAAATGGCGGCAATCTGGGC
GTCTGACGATCCAAAAACAGCTATGCATGATGCTAAAGTCAATCGTCAAATGCCAGCGTCTGGTAAAGACCTAGCAGAGC
AAAAGCAGATCATTGCTAAACAATACCAACTCGGTCGTGAGCTTGGCATCAATGGCACTCCGGCTATCGTGCTAGCAAGT
GGTGAGTTGGTGAGTGGTTACTTACCTCCGGCGCAACTTATTCAGCGTTTAGAGCAGTAA

Upstream 100 bases:

>100_bases
CCACCCAAATTTATACTCACGTGGCGACTGAAAGGCTGAAGCAAATTCACGCTCAGCATCACCCACGTGCTTAAATCCAT
TTATTTTTAAGGTGAACCTA

Downstream 100 bases:

>100_bases
TCTTCATTTTTTATTACCTATTATTCCCCCCTGTTTTTGATTTAAGGAGTGGCCTGATTGATATCAGGCCCATTTTTATA
TGATAGAGATCCAACGCCGT

Product: thiol:disulfide interchange protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSVLRRLPLLALPLMITACNASEAKVETTSTAVEAAPAQAIDTAALTKRFEKIGIKVDKIVPSDIDGLLEVQTNSGIIFS
SPEGDHFLAGTLYSLDENGKFSDVLAERQAPLNAEKVAAMSDTVIEYKADNEKYVVTVFTDITCGYCVRLHSQMQGYNDL
GITVRYMAYPRQGATGQVADQMAAIWASDDPKTAMHDAKVNRQMPASGKDLAEQKQIIAKQYQLGRELGINGTPAIVLAS
GELVSGYLPPAQLIQRLEQ

Sequences:

>Translated_259_residues
MSVLRRLPLLALPLMITACNASEAKVETTSTAVEAAPAQAIDTAALTKRFEKIGIKVDKIVPSDIDGLLEVQTNSGIIFS
SPEGDHFLAGTLYSLDENGKFSDVLAERQAPLNAEKVAAMSDTVIEYKADNEKYVVTVFTDITCGYCVRLHSQMQGYNDL
GITVRYMAYPRQGATGQVADQMAAIWASDDPKTAMHDAKVNRQMPASGKDLAEQKQIIAKQYQLGRELGINGTPAIVLAS
GELVSGYLPPAQLIQRLEQ
>Mature_258_residues
SVLRRLPLLALPLMITACNASEAKVETTSTAVEAAPAQAIDTAALTKRFEKIGIKVDKIVPSDIDGLLEVQTNSGIIFSS
PEGDHFLAGTLYSLDENGKFSDVLAERQAPLNAEKVAAMSDTVIEYKADNEKYVVTVFTDITCGYCVRLHSQMQGYNDLG
ITVRYMAYPRQGATGQVADQMAAIWASDDPKTAMHDAKVNRQMPASGKDLAEQKQIIAKQYQLGRELGINGTPAIVLASG
ELVSGYLPPAQLIQRLEQ

Specific function: Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1789260, Length=228, Percent_Identity=40.7894736842105, Blast_Score=170, Evalue=7e-44,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018950
- InterPro:   IPR009094
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10411 DsbC_N [H]

EC number: 5.3.4.1

Molecular weight: Translated: 28034; Mature: 27903

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLRRLPLLALPLMITACNASEAKVETTSTAVEAAPAQAIDTAALTKRFEKIGIKVDKI
CCHHHHHHHHHHHHHHEECCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEE
VPSDIDGLLEVQTNSGIIFSSPEGDHFLAGTLYSLDENGKFSDVLAERQAPLNAEKVAAM
CCCCCCCEEEEECCCCEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHH
SDTVIEYKADNEKYVVTVFTDITCGYCVRLHSQMQGYNDLGITVRYMAYPRQGATGQVAD
HCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHH
QMAAIWASDDPKTAMHDAKVNRQMPASGKDLAEQKQIIAKQYQLGRELGINGTPAIVLAS
HHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
GELVSGYLPPAQLIQRLEQ
CCEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
SVLRRLPLLALPLMITACNASEAKVETTSTAVEAAPAQAIDTAALTKRFEKIGIKVDKI
CHHHHHHHHHHHHHHEECCCCCCEEEHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEEE
VPSDIDGLLEVQTNSGIIFSSPEGDHFLAGTLYSLDENGKFSDVLAERQAPLNAEKVAAM
CCCCCCCEEEEECCCCEEEECCCCCEEEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHH
SDTVIEYKADNEKYVVTVFTDITCGYCVRLHSQMQGYNDLGITVRYMAYPRQGATGQVAD
HCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHH
QMAAIWASDDPKTAMHDAKVNRQMPASGKDLAEQKQIIAKQYQLGRELGINGTPAIVLAS
HHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
GELVSGYLPPAQLIQRLEQ
CCEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]