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The map label for this gene is ung [H]

Identifier: 218708535

GI number: 218708535

Start: 520448

End: 521122

Strand: Direct

Name: ung [H]

Synonym: VS_0501

Alternate gene names: 218708535

Gene position: 520448-521122 (Clockwise)

Preceding gene: 218708534

Following gene: 218708536

Centisome position: 15.77

GC content: 47.41

Gene sequence:

>675_bases
ATGAGCGCGCCAAAAACTTGGGAATCCATTATTAATGATGAACGTGACAAAGAGTACTTTCAGAGTGTCCTCGCGTTTGT
TGAACAGCAACGCAATAGTGGGAAAACCGTCTACCCTCCTCAAGAGCAGGTGTTCAGTGCCTTTGATATGACGCCTTTCG
AGTCCGTACGCGTGGTTATCCTGGGGCAAGATCCTTATCACGGCGCTAACCAAGCTCATGGCTTAGCTTTTTCTGTACTG
CCAGGTGTAAAAATCCCTCCTTCTCTACGTAATATGTACAAAGAGCTTGCACAAGATATAGAGGGCTTTGAGATCCCGAG
TCATGGCTACCTCGATTCTTGGGCATCTCAAGGGGTGTTGATGTTGAACACTGTCCTTACAGTAGAAGAGGCAAAAGCCC
ACTCACATGCTAAGTGTGGTTGGGAAACCTTTACCGATGCCATTATTGCAGAGCTCAATCAGCGCTCTGAACCGATCATC
TTCTTGTTGTGGGGCGCACACGCCCAGAAGAAAGGCCAAGCGATTGATGCAGACAAGCACCATGTGTTGGTTGCACCTCA
TCCATCACCATTATCAGCACGCCGTGGTTTCTTCGGTTGTCAGCACTTCTCAACAACCAACAAGCTACTTTCTTCTATGG
ATCAACAATCTATCGACTGGCGTTTACCAACATAA

Upstream 100 bases:

>100_bases
TCAACACGCCCTAAAGCCTTATTTAGGACAGTTAGCCGATACAGCTATTTTTTTGTCTGGCGAAAGCCCCTAGAAATCTT
GATGATTGGGAAGTAAAACG

Downstream 100 bases:

>100_bases
GTATAGGTTGGTGGTTTTCTGAGCAGGGTCAAATCATAAATCAGCATCTTCGTATACACTTATAAACAGTAGGTGTAATG
GAGTGCAATACTATGATGAT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSAPKTWESIINDERDKEYFQSVLAFVEQQRNSGKTVYPPQEQVFSAFDMTPFESVRVVILGQDPYHGANQAHGLAFSVL
PGVKIPPSLRNMYKELAQDIEGFEIPSHGYLDSWASQGVLMLNTVLTVEEAKAHSHAKCGWETFTDAIIAELNQRSEPII
FLLWGAHAQKKGQAIDADKHHVLVAPHPSPLSARRGFFGCQHFSTTNKLLSSMDQQSIDWRLPT

Sequences:

>Translated_224_residues
MSAPKTWESIINDERDKEYFQSVLAFVEQQRNSGKTVYPPQEQVFSAFDMTPFESVRVVILGQDPYHGANQAHGLAFSVL
PGVKIPPSLRNMYKELAQDIEGFEIPSHGYLDSWASQGVLMLNTVLTVEEAKAHSHAKCGWETFTDAIIAELNQRSEPII
FLLWGAHAQKKGQAIDADKHHVLVAPHPSPLSARRGFFGCQHFSTTNKLLSSMDQQSIDWRLPT
>Mature_223_residues
SAPKTWESIINDERDKEYFQSVLAFVEQQRNSGKTVYPPQEQVFSAFDMTPFESVRVVILGQDPYHGANQAHGLAFSVLP
GVKIPPSLRNMYKELAQDIEGFEIPSHGYLDSWASQGVLMLNTVLTVEEAKAHSHAKCGWETFTDAIIAELNQRSEPIIF
LLWGAHAQKKGQAIDADKHHVLVAPHPSPLSARRGFFGCQHFSTTNKLLSSMDQQSIDWRLPT

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=217, Percent_Identity=55.7603686635945, Blast_Score=249, Evalue=9e-67,
Organism=Homo sapiens, GI6224979, Length=217, Percent_Identity=55.7603686635945, Blast_Score=249, Evalue=1e-66,
Organism=Escherichia coli, GI1788934, Length=220, Percent_Identity=60, Blast_Score=285, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=50.6912442396313, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323620, Length=233, Percent_Identity=45.0643776824034, Blast_Score=184, Evalue=8e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25119; Mature: 24987

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPKTWESIINDERDKEYFQSVLAFVEQQRNSGKTVYPPQEQVFSAFDMTPFESVRVVI
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEE
LGQDPYHGANQAHGLAFSVLPGVKIPPSLRNMYKELAQDIEGFEIPSHGYLDSWASQGVL
ECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEE
MLNTVLTVEEAKAHSHAKCGWETFTDAIIAELNQRSEPIIFLLWGAHAQKKGQAIDADKH
EEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
HVLVAPHPSPLSARRGFFGCQHFSTTNKLLSSMDQQSIDWRLPT
EEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
SAPKTWESIINDERDKEYFQSVLAFVEQQRNSGKTVYPPQEQVFSAFDMTPFESVRVVI
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCEEEEE
LGQDPYHGANQAHGLAFSVLPGVKIPPSLRNMYKELAQDIEGFEIPSHGYLDSWASQGVL
ECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCEE
MLNTVLTVEEAKAHSHAKCGWETFTDAIIAELNQRSEPIIFLLWGAHAQKKGQAIDADKH
EEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCC
HVLVAPHPSPLSARRGFFGCQHFSTTNKLLSSMDQQSIDWRLPT
EEEECCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA