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The map label for this gene is kdsA [H]

Identifier: 218708278

GI number: 218708278

Start: 210632

End: 211429

Strand: Direct

Name: kdsA [H]

Synonym: VS_0216

Alternate gene names: 218708278

Gene position: 210632-211429 (Clockwise)

Preceding gene: 218708277

Following gene: 218708279

Centisome position: 6.38

GC content: 40.85

Gene sequence:

>798_bases
ATGTTTTTAATTGCTGGTCCTTGTGTTATTGAATCTGAGCAACTGGTTCTAGATACATTTGGTAGATTACAAGAAATTAC
AAGTAAACTTGGTATTGAATATATTGCTAAGTCCTCTTTTACCAAAGCTAATCGCTCATCTGCTTCCGCCTTTACTGGTC
CGGGAATAGAAGAAGGGTTGAAGATTCTTCAAAAAGCAAAAGAACAACTAGGTGTGAAAATTATCACAGATGTTCATGAT
GATACTCCTTTAGATGAAGTTGCTTCAGTCGTTGATGTTTTACAAACCCCTGCCTTCCTTGTTCGTCAAACAGGTTTTAT
TCAACGAGTTGCGTCAATGGGTAAACCTGTCAACATTAAAAAAGGTCAGTGGATGCACCCATCAGACATGGTTCCAGTAG
TAGAGAAATGCCGCGCAGTTGGTAACGATGATATATGGCTATGTGATCGTGGTACTAGCTTTGGTTTTGGTCAACTCGTT
AACTATATGCCTGGCTTAACTATCATGAAAGAAACTGGGTGCAAGGTTGTCATGGACGCAACGCACAGTGTTCAAATGCC
TGGTACTCTAAATGGTTCTACAGGTGGGAATCGCTATCACGTCCCAGCGATTGCAAGAGCTGCAGTGGCTGTAGGTATTG
ATGGCTTGTTTATGGAAACTCACCCTGAACCAGATAATGCATTATGTGACGGGCCAAATATGTTGCCACTGAAACATATG
GAAGAGCTATTAGAGACTTTACTTGAGATCGATGAAGTTGTTCATCGTCGCGCTTTTATAGAGTCTAAACTGGTTTAA

Upstream 100 bases:

>100_bases
TGGGATAGTGAAATTAGGCTGTCTCAAAATGGATAAAAAAGTATCTCAGTGAATTATAGAGGGCTGAGGTGTAAAGTTAA
TCAAACTAATGGAAGATGAC

Downstream 100 bases:

>100_bases
TTATGTTGGATAAAAAGGTCTGTAAAAATATCAAAATGGTTTTACTTGATGTTGATGGAGTAATGACGGATGGCTCTATC
TATATTAATCAAGACGGTGA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MFLIAGPCVIESEQLVLDTFGRLQEITSKLGIEYIAKSSFTKANRSSASAFTGPGIEEGLKILQKAKEQLGVKIITDVHD
DTPLDEVASVVDVLQTPAFLVRQTGFIQRVASMGKPVNIKKGQWMHPSDMVPVVEKCRAVGNDDIWLCDRGTSFGFGQLV
NYMPGLTIMKETGCKVVMDATHSVQMPGTLNGSTGGNRYHVPAIARAAVAVGIDGLFMETHPEPDNALCDGPNMLPLKHM
EELLETLLEIDEVVHRRAFIESKLV

Sequences:

>Translated_265_residues
MFLIAGPCVIESEQLVLDTFGRLQEITSKLGIEYIAKSSFTKANRSSASAFTGPGIEEGLKILQKAKEQLGVKIITDVHD
DTPLDEVASVVDVLQTPAFLVRQTGFIQRVASMGKPVNIKKGQWMHPSDMVPVVEKCRAVGNDDIWLCDRGTSFGFGQLV
NYMPGLTIMKETGCKVVMDATHSVQMPGTLNGSTGGNRYHVPAIARAAVAVGIDGLFMETHPEPDNALCDGPNMLPLKHM
EELLETLLEIDEVVHRRAFIESKLV
>Mature_265_residues
MFLIAGPCVIESEQLVLDTFGRLQEITSKLGIEYIAKSSFTKANRSSASAFTGPGIEEGLKILQKAKEQLGVKIITDVHD
DTPLDEVASVVDVLQTPAFLVRQTGFIQRVASMGKPVNIKKGQWMHPSDMVPVVEKCRAVGNDDIWLCDRGTSFGFGQLV
NYMPGLTIMKETGCKVVMDATHSVQMPGTLNGSTGGNRYHVPAIARAAVAVGIDGLFMETHPEPDNALCDGPNMLPLKHM
EELLETLLEIDEVVHRRAFIESKLV

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=254, Percent_Identity=45.2755905511811, Blast_Score=231, Evalue=3e-62,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 28906; Mature: 28906

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLIAGPCVIESEQLVLDTFGRLQEITSKLGIEYIAKSSFTKANRSSASAFTGPGIEEGL
CEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
KILQKAKEQLGVKIITDVHDDTPLDEVASVVDVLQTPAFLVRQTGFIQRVASMGKPVNIK
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCC
KGQWMHPSDMVPVVEKCRAVGNDDIWLCDRGTSFGFGQLVNYMPGLTIMKETGCKVVMDA
CCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCEEEEEC
THSVQMPGTLNGSTGGNRYHVPAIARAAVAVGIDGLFMETHPEPDNALCDGPNMLPLKHM
CCCEECCCCCCCCCCCCEEECHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHH
EELLETLLEIDEVVHRRAFIESKLV
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFLIAGPCVIESEQLVLDTFGRLQEITSKLGIEYIAKSSFTKANRSSASAFTGPGIEEGL
CEEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
KILQKAKEQLGVKIITDVHDDTPLDEVASVVDVLQTPAFLVRQTGFIQRVASMGKPVNIK
HHHHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCC
KGQWMHPSDMVPVVEKCRAVGNDDIWLCDRGTSFGFGQLVNYMPGLTIMKETGCKVVMDA
CCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCEEEEEC
THSVQMPGTLNGSTGGNRYHVPAIARAAVAVGIDGLFMETHPEPDNALCDGPNMLPLKHM
CCCEECCCCCCCCCCCCEEECHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHH
EELLETLLEIDEVVHRRAFIESKLV
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA