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The map label for this gene is wzc [H]

Identifier: 218708277

GI number: 218708277

Start: 208009

End: 210177

Strand: Direct

Name: wzc [H]

Synonym: VS_0215

Alternate gene names: 218708277

Gene position: 208009-210177 (Clockwise)

Preceding gene: 218708276

Following gene: 218708278

Centisome position: 6.3

GC content: 42.69

Gene sequence:

>2169_bases
ATGACAATACAACCATCTCAGCAATCACACACAGATAACTCTGATGAGATAGATTTAGGGAAACTGCTTGGTATCTTATT
AGATGCTAAATGGCTAATCATGCTGACCACATTCGTTTTTTCTGTGTTTGGTATTGCGTTTGCCCTCCTTTCAACTCCGA
TATACAAAGCAGATGCATTAATTCAAATTGAAGAAAAGAGCTCTGGTGGCATTTCATCAATGGTCGGTGACATGGGCGAG
TTGTTTTCTCAGGAATCTTCTGCGACGACAGAAGTTGAGATCATTAAATCTCGTATGATCTTGGGTGAAACGGTTGATAA
GTTTAACTTAACCACCGTAACTTCACCGAACTATGCACCAATCATTGGTAAAGGACTCGCTCGCTTAACCGGTAACATCA
ACCATATTGCAGTGAGCCGTTTTACGTTGCCAAGCCATATGGAGGATTACACACACACGATTCAGATTCTTGATGTTGAG
CAAGGTACTTACCAACTCGTTCGTGATGATGAACGTATTATCTTTAAAGGTAAAGTAGGTGAACTCGTGACAGCAGACGA
TTACAGCTTGTTTGTGGCTGGCTTCGAGTCAAACAATGGCTTTGAATTTACCATTGGTAAACGCAGCAGATTAGAAGCTA
TCGAGTGGCTGAAATCTTCTTTGTCTCTGTCTGAGCAAGGTAAGCAAACTGGTATTTTGAAGCTAAGCTTTGAAGGCGAA
AACAAGCTGAAGATCTCTGAGATACTCAACCATATCAGCCAGATATATTTCTTACAAAACGTGAAACGTAATTCAGCGGA
AGCAGAGAAGAGCCTATCGTTCTTAGAAAGCCATCTTCCAGGCATTAAGTCTGAGTTAACTGGTTACGAAGACATATTAA
ACAACTATCGCCAAGAAAACGAATCGATCGACTTGGGCTTAGAAGCACAATCAACCTTGAGGGTAATGGTAGAGCTTGAA
GCGCAATTGAATGAGCTGACGTTCAAAGAGAGCGAAATAAGCCAACGTTTTACTAAAGATCACCCGGCATACAAAGCATT
GTTGGATAAGCGTAAAACGCTATTGGGCGAGAAAGAACGTCAGAACAAGCAAGTGCAAAAATTACCAAAGACACAGCGCG
AAGTGCTACGTATGACTCGTGATGTTGAAGTAAACCAGCAGATCTACATCCAACTGATGAATAAAGTTCAGGAGCTGGGC
ATTATCAAAGCCGGCACCGTAGGTAACGTTCGTATCTTAGATGACGCTCAAACTTATGCTCACGCAGTTAAACCTAAGAA
GCCGCTGATTGTTGTGTTAGCTACGCTACTGGGTGGTATGCTAAGTATCGCGTTTGTGTTAGTAAAAGCGGCGTTCCACC
GAGGTGTTGACAGCCCGGACCAAATTGAACAGATTGGCCTACCAGTATACGCAGCCGTACCAAAATCAGACTTTCAGATA
GAGCTAACTAACCGCTTTAAATCGAAGAAGAAGAACCAGGGGACTCAAGCGCTGCTTGCTGAATCTAACCCTGCGGATCT
TTCGGTTGAAGCACTGCGTGGCCTTCGTACTAGCTTGCACTTCGCGATGCTAGAAGCGAAAAACAACATTCTGATGATTT
CAGGTCCTGCTCCGGGCATTGGTAAATCATTTATTTCGACCAACTTCTCCGCAGTAGCAGCCCAAACAGGTCAAAAAGTA
CTGTTGATTGATGCCGATATGCGTAAAGGTTACCTACAACAAAGCTTTGGTGTTAACTGGGATAACGGTCTTTCGGATGT
ATTAAGCGGTAAGCAAGAGTTTGCTCAGTCCATTAAAACAACAGCAATAGAGAACCTAGAAATTATTACTCGCGGTCAAG
TACCACCCAACCCATCTGAATTGTTGATGCACCCACGCTTTGCCGAACTAATGGAGTGGGCTTCAAAAGAGTACGACTTA
GTGATTGTTGATACCCCTCCAATACTTGCTGTAACCGATCCAAGTATTGTTGGCGCTTTTGCTGGTACTACATTAATGGT
GGCCCGTTTTGGTCAAAATACCATTAAAGAAATCGATGTTGCTCGTAATCGCTTCGAACAGTCTGGTATTGAAGTTAAAG
GTGTTATCTTTAACGCCATCGAAAAGAAAGCATCAAGTTCTTATGGCTACGGTTACTACAACTATGCATATTCGAGTAAC
AATACGTAA

Upstream 100 bases:

>100_bases
TAAGCTTGAATTACCAACGATAGAATCTCATAAGAGAGAAGGGTACGTAAGCCGTACGTCACTTATCTTAAAAAATATTA
GTTTAGGAAGTAGTAATCTG

Downstream 100 bases:

>100_bases
TATATCATCAGATGCCAAAGAGCAGTAACGAGATGCGAGTAATCGGAAAGATAGAATCTGGCACGTATCCCTCTTACTTG
TCACTCTAGTCTAACTTTTC

Product: putative tyrosine-protein kinase

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 722; Mature: 721

Protein sequence:

>722_residues
MTIQPSQQSHTDNSDEIDLGKLLGILLDAKWLIMLTTFVFSVFGIAFALLSTPIYKADALIQIEEKSSGGISSMVGDMGE
LFSQESSATTEVEIIKSRMILGETVDKFNLTTVTSPNYAPIIGKGLARLTGNINHIAVSRFTLPSHMEDYTHTIQILDVE
QGTYQLVRDDERIIFKGKVGELVTADDYSLFVAGFESNNGFEFTIGKRSRLEAIEWLKSSLSLSEQGKQTGILKLSFEGE
NKLKISEILNHISQIYFLQNVKRNSAEAEKSLSFLESHLPGIKSELTGYEDILNNYRQENESIDLGLEAQSTLRVMVELE
AQLNELTFKESEISQRFTKDHPAYKALLDKRKTLLGEKERQNKQVQKLPKTQREVLRMTRDVEVNQQIYIQLMNKVQELG
IIKAGTVGNVRILDDAQTYAHAVKPKKPLIVVLATLLGGMLSIAFVLVKAAFHRGVDSPDQIEQIGLPVYAAVPKSDFQI
ELTNRFKSKKKNQGTQALLAESNPADLSVEALRGLRTSLHFAMLEAKNNILMISGPAPGIGKSFISTNFSAVAAQTGQKV
LLIDADMRKGYLQQSFGVNWDNGLSDVLSGKQEFAQSIKTTAIENLEIITRGQVPPNPSELLMHPRFAELMEWASKEYDL
VIVDTPPILAVTDPSIVGAFAGTTLMVARFGQNTIKEIDVARNRFEQSGIEVKGVIFNAIEKKASSSYGYGYYNYAYSSN
NT

Sequences:

>Translated_722_residues
MTIQPSQQSHTDNSDEIDLGKLLGILLDAKWLIMLTTFVFSVFGIAFALLSTPIYKADALIQIEEKSSGGISSMVGDMGE
LFSQESSATTEVEIIKSRMILGETVDKFNLTTVTSPNYAPIIGKGLARLTGNINHIAVSRFTLPSHMEDYTHTIQILDVE
QGTYQLVRDDERIIFKGKVGELVTADDYSLFVAGFESNNGFEFTIGKRSRLEAIEWLKSSLSLSEQGKQTGILKLSFEGE
NKLKISEILNHISQIYFLQNVKRNSAEAEKSLSFLESHLPGIKSELTGYEDILNNYRQENESIDLGLEAQSTLRVMVELE
AQLNELTFKESEISQRFTKDHPAYKALLDKRKTLLGEKERQNKQVQKLPKTQREVLRMTRDVEVNQQIYIQLMNKVQELG
IIKAGTVGNVRILDDAQTYAHAVKPKKPLIVVLATLLGGMLSIAFVLVKAAFHRGVDSPDQIEQIGLPVYAAVPKSDFQI
ELTNRFKSKKKNQGTQALLAESNPADLSVEALRGLRTSLHFAMLEAKNNILMISGPAPGIGKSFISTNFSAVAAQTGQKV
LLIDADMRKGYLQQSFGVNWDNGLSDVLSGKQEFAQSIKTTAIENLEIITRGQVPPNPSELLMHPRFAELMEWASKEYDL
VIVDTPPILAVTDPSIVGAFAGTTLMVARFGQNTIKEIDVARNRFEQSGIEVKGVIFNAIEKKASSSYGYGYYNYAYSSN
NT
>Mature_721_residues
TIQPSQQSHTDNSDEIDLGKLLGILLDAKWLIMLTTFVFSVFGIAFALLSTPIYKADALIQIEEKSSGGISSMVGDMGEL
FSQESSATTEVEIIKSRMILGETVDKFNLTTVTSPNYAPIIGKGLARLTGNINHIAVSRFTLPSHMEDYTHTIQILDVEQ
GTYQLVRDDERIIFKGKVGELVTADDYSLFVAGFESNNGFEFTIGKRSRLEAIEWLKSSLSLSEQGKQTGILKLSFEGEN
KLKISEILNHISQIYFLQNVKRNSAEAEKSLSFLESHLPGIKSELTGYEDILNNYRQENESIDLGLEAQSTLRVMVELEA
QLNELTFKESEISQRFTKDHPAYKALLDKRKTLLGEKERQNKQVQKLPKTQREVLRMTRDVEVNQQIYIQLMNKVQELGI
IKAGTVGNVRILDDAQTYAHAVKPKKPLIVVLATLLGGMLSIAFVLVKAAFHRGVDSPDQIEQIGLPVYAAVPKSDFQIE
LTNRFKSKKKNQGTQALLAESNPADLSVEALRGLRTSLHFAMLEAKNNILMISGPAPGIGKSFISTNFSAVAAQTGQKVL
LIDADMRKGYLQQSFGVNWDNGLSDVLSGKQEFAQSIKTTAIENLEIITRGQVPPNPSELLMHPRFAELMEWASKEYDLV
IVDTPPILAVTDPSIVGAFAGTTLMVARFGQNTIKEIDVARNRFEQSGIEVKGVIFNAIEKKASSSYGYGYYNYAYSSNN
T

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium. Phosphorylates udg [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=714, Percent_Identity=47.7591036414566, Blast_Score=677, Evalue=0.0,
Organism=Escherichia coli, GI1787216, Length=704, Percent_Identity=45.4545454545455, Blast_Score=618, Evalue=1e-178,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 80119; Mature: 79987

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQPSQQSHTDNSDEIDLGKLLGILLDAKWLIMLTTFVFSVFGIAFALLSTPIYKADAL
CCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
IQIEEKSSGGISSMVGDMGELFSQESSATTEVEIIKSRMILGETVDKFNLTTVTSPNYAP
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
IIGKGLARLTGNINHIAVSRFTLPSHMEDYTHTIQILDVEQGTYQLVRDDERIIFKGKVG
HHHHHHHHHCCCCCEEEEEEEECCHHHHCCCEEEEEEEECCCCCCEECCCCEEEEECCCC
ELVTADDYSLFVAGFESNNGFEFTIGKRSRLEAIEWLKSSLSLSEQGKQTGILKLSFEGE
CEEEECCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCC
NKLKISEILNHISQIYFLQNVKRNSAEAEKSLSFLESHLPGIKSELTGYEDILNNYRQEN
CCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCC
ESIDLGLEAQSTLRVMVELEAQLNELTFKESEISQRFTKDHPAYKALLDKRKTLLGEKER
CCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHH
QNKQVQKLPKTQREVLRMTRDVEVNQQIYIQLMNKVQELGIIKAGTVGNVRILDDAQTYA
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECHHHHH
HAVKPKKPLIVVLATLLGGMLSIAFVLVKAAFHRGVDSPDQIEQIGLPVYAAVPKSDFQI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCCCCEE
ELTNRFKSKKKNQGTQALLAESNPADLSVEALRGLRTSLHFAMLEAKNNILMISGPAPGI
EEHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEECCCCCC
GKSFISTNFSAVAAQTGQKVLLIDADMRKGYLQQSFGVNWDNGLSDVLSGKQEFAQSIKT
CHHHHHCCHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHH
TAIENLEIITRGQVPPNPSELLMHPRFAELMEWASKEYDLVIVDTPPILAVTDPSIVGAF
HHHCCEEEEECCCCCCCHHHHHCCCHHHHHHHHCCCCCCEEEECCCCEEEECCCHHHHHH
AGTTLMVARFGQNTIKEIDVARNRFEQSGIEVKGVIFNAIEKKASSSYGYGYYNYAYSSN
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCEEEEEECCC
NT
CC
>Mature Secondary Structure 
TIQPSQQSHTDNSDEIDLGKLLGILLDAKWLIMLTTFVFSVFGIAFALLSTPIYKADAL
CCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
IQIEEKSSGGISSMVGDMGELFSQESSATTEVEIIKSRMILGETVDKFNLTTVTSPNYAP
EEEECCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCC
IIGKGLARLTGNINHIAVSRFTLPSHMEDYTHTIQILDVEQGTYQLVRDDERIIFKGKVG
HHHHHHHHHCCCCCEEEEEEEECCHHHHCCCEEEEEEEECCCCCCEECCCCEEEEECCCC
ELVTADDYSLFVAGFESNNGFEFTIGKRSRLEAIEWLKSSLSLSEQGKQTGILKLSFEGE
CEEEECCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCC
NKLKISEILNHISQIYFLQNVKRNSAEAEKSLSFLESHLPGIKSELTGYEDILNNYRQEN
CCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCC
ESIDLGLEAQSTLRVMVELEAQLNELTFKESEISQRFTKDHPAYKALLDKRKTLLGEKER
CCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHH
QNKQVQKLPKTQREVLRMTRDVEVNQQIYIQLMNKVQELGIIKAGTVGNVRILDDAQTYA
HHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCEEEEECHHHHH
HAVKPKKPLIVVLATLLGGMLSIAFVLVKAAFHRGVDSPDQIEQIGLPVYAAVPKSDFQI
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCCCCEE
ELTNRFKSKKKNQGTQALLAESNPADLSVEALRGLRTSLHFAMLEAKNNILMISGPAPGI
EEHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHEEECCCCEEEEECCCCCC
GKSFISTNFSAVAAQTGQKVLLIDADMRKGYLQQSFGVNWDNGLSDVLSGKQEFAQSIKT
CHHHHHCCHHHHHHCCCCEEEEEECHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHH
TAIENLEIITRGQVPPNPSELLMHPRFAELMEWASKEYDLVIVDTPPILAVTDPSIVGAF
HHHCCEEEEECCCCCCCHHHHHCCCHHHHHHHHCCCCCCEEEECCCCEEEECCCHHHHHH
AGTTLMVARFGQNTIKEIDVARNRFEQSGIEVKGVIFNAIEKKASSSYGYGYYNYAYSSN
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCEEEEEECCC
NT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]