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The map label for this gene is mutM

Identifier: 218708249

GI number: 218708249

Start: 181527

End: 182336

Strand: Direct

Name: mutM

Synonym: VS_0186

Alternate gene names: 218708249

Gene position: 181527-182336 (Clockwise)

Preceding gene: 218708248

Following gene: 218708250

Centisome position: 5.5

GC content: 46.42

Gene sequence:

>810_bases
ATGCCTGAATTACCCGAAGTTGAAGTAAGCCGCATGGGGATCTCGCCTCATTTAGTCGGTGAGACGATTAAAACGCTTAC
CTTTCGTACCCCCAAACTGCGTTGGGATATCCCTCAAGAACTTAAGCGATTAGAAGGGCAGGTGATTCGCTCTATCTCGC
GTCGTGCAAAGTATTTATTGATTGAGACAGATACAGGCACTGCGATTGTGCATCTTGGTATGTCAGGTTCACTGCGCGTG
TTGGATGCCGATTTCCCGCCAGCAAAACACGATCACGTGGATCTTAAGTTAACCAATGGCAAGATCTTGCGTTATAACGA
TCCGCGTCGCTTTGGTGCGTGGTTATGGTCGGCGCCTGATGAGATACATACTGTATTACTTGGTTCTGGTCCTGAGCCAC
TAACTGACGACTTCAACGCAGATTACATTGCTGAGAAAGCAGAAAAGCGTAAGGTTGCCGTCAAACAGTTCATTATGGAC
AACAAAGTCGTGGTCGGTGTGGGTAATATCTACGCCAATGAAGCTCTGTTTTCTTCACGTATTAATCCTTTGCGCTCTGC
AAGTAAGGTTACAAAACAAGAGTGGCTCTTGTTAACCAAAGAGATCAAGCAAGTACTCGCGACGGCTATCAGACAGGGTG
GAACAACGCTAAAAGACTTTGCCCAAGCGGATGGAAAACCGGGATATTTTGCTCAAGAGCTGCAGGTTTATGGTAAGGCT
GGTGAACAGTGTCCTAACTGTGCAGAGCTGATTCAGGAACTTAAAATCGGGCAAAGAAACACGTTTTATTGCTCTAGCTG
TCAGGTATAG

Upstream 100 bases:

>100_bases
TTCCAGAATTTGGCTCAGACCAGTCCTTTAAATCATACCAGTCATTCAAATCAGACAAGCTATCTATATCAGACGAACCA
TCTCTATCGGACGACTAACT

Downstream 100 bases:

>100_bases
ATGTGTCCTTCTCAACACAGAAGTTGATATCACTTGAAGCTGTGTCTAGGGCACTTTATCTGATAAAATTACGGGTATTA
TTGTGGAATTTGTCGTCTTC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPELPEVEVSRMGISPHLVGETIKTLTFRTPKLRWDIPQELKRLEGQVIRSISRRAKYLLIETDTGTAIVHLGMSGSLRV
LDADFPPAKHDHVDLKLTNGKILRYNDPRRFGAWLWSAPDEIHTVLLGSGPEPLTDDFNADYIAEKAEKRKVAVKQFIMD
NKVVVGVGNIYANEALFSSRINPLRSASKVTKQEWLLLTKEIKQVLATAIRQGGTTLKDFAQADGKPGYFAQELQVYGKA
GEQCPNCAELIQELKIGQRNTFYCSSCQV

Sequences:

>Translated_269_residues
MPELPEVEVSRMGISPHLVGETIKTLTFRTPKLRWDIPQELKRLEGQVIRSISRRAKYLLIETDTGTAIVHLGMSGSLRV
LDADFPPAKHDHVDLKLTNGKILRYNDPRRFGAWLWSAPDEIHTVLLGSGPEPLTDDFNADYIAEKAEKRKVAVKQFIMD
NKVVVGVGNIYANEALFSSRINPLRSASKVTKQEWLLLTKEIKQVLATAIRQGGTTLKDFAQADGKPGYFAQELQVYGKA
GEQCPNCAELIQELKIGQRNTFYCSSCQV
>Mature_268_residues
PELPEVEVSRMGISPHLVGETIKTLTFRTPKLRWDIPQELKRLEGQVIRSISRRAKYLLIETDTGTAIVHLGMSGSLRVL
DADFPPAKHDHVDLKLTNGKILRYNDPRRFGAWLWSAPDEIHTVLLGSGPEPLTDDFNADYIAEKAEKRKVAVKQFIMDN
KVVVGVGNIYANEALFSSRINPLRSASKVTKQEWLLLTKEIKQVLATAIRQGGTTLKDFAQADGKPGYFAQELQVYGKAG
EQCPNCAELIQELKIGQRNTFYCSSCQV

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=268, Percent_Identity=59.7014925373134, Blast_Score=334, Evalue=4e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_VIBSL (B7VHK6)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002415870.1
- GeneID:   7159856
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0186
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK01103
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30122; Mature: 29991

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 57-57 ACT_SITE 259-259 BINDING 90-90 BINDING 109-109 BINDING 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVEVSRMGISPHLVGETIKTLTFRTPKLRWDIPQELKRLEGQVIRSISRRAKYLL
CCCCCCCHHHHCCCCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEE
IETDTGTAIVHLGMSGSLRVLDADFPPAKHDHVDLKLTNGKILRYNDPRRFGAWLWSAPD
EECCCCCEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCEEEEECCCHHHHHHHCCCCH
EIHTVLLGSGPEPLTDDFNADYIAEKAEKRKVAVKQFIMDNKVVVGVGNIYANEALFSSR
HHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
INPLRSASKVTKQEWLLLTKEIKQVLATAIRQGGTTLKDFAQADGKPGYFAQELQVYGKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHCC
GEQCPNCAELIQELKIGQRNTFYCSSCQV
CCCCCCHHHHHHHHHCCCCCCEEECCCCC
>Mature Secondary Structure 
PELPEVEVSRMGISPHLVGETIKTLTFRTPKLRWDIPQELKRLEGQVIRSISRRAKYLL
CCCCCCHHHHCCCCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCEEEE
IETDTGTAIVHLGMSGSLRVLDADFPPAKHDHVDLKLTNGKILRYNDPRRFGAWLWSAPD
EECCCCCEEEEECCCCCEEEEECCCCCCCCCEEEEEEECCEEEEECCCHHHHHHHCCCCH
EIHTVLLGSGPEPLTDDFNADYIAEKAEKRKVAVKQFIMDNKVVVGVGNIYANEALFSSR
HHEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHH
INPLRSASKVTKQEWLLLTKEIKQVLATAIRQGGTTLKDFAQADGKPGYFAQELQVYGKA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHCC
GEQCPNCAELIQELKIGQRNTFYCSSCQV
CCCCCCHHHHHHHHHCCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA