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The map label for this gene is ubiB

Identifier: 218708166

GI number: 218708166

Start: 92124

End: 93758

Strand: Direct

Name: ubiB

Synonym: VS_0100

Alternate gene names: 218708166

Gene position: 92124-93758 (Clockwise)

Preceding gene: 218708165

Following gene: 218708167

Centisome position: 2.79

GC content: 48.32

Gene sequence:

>1635_bases
ATGACCCCAGCAGAACTGAAACGTCTTTATCATATTATCAAGGTACAGTTGGAATACGGCCTTGATGAGTTGATGCCGGA
ACACCAACTGACTAAAGCCCCTTTGTTGGCGCGAAAGTCACTGTTTTGGCTCAAGAACAAGCATCAAGATAAAGAGTTGG
GTCATCGCTTGCGCCTTGCGCTGCAAGAACTTGGTCCAGTGTGGATCAAGTTTGGACAGATGATGTCGACACGTCGTGAT
CTGTTCCCTCCTCATATCGCCGATCAGTTGGCGTTGTTGCAAGACCAAGTTGCGCCGTTTGATGGTCAATTGGCTAAGCG
AGACATGGAAAAAGCGCTCGGTGGTCGCCTAGATAACTGGTTTACCGACTTTGATATCGAGCCATTGGCTTCTGCTTCTA
TCGCTCAGGTGCATACCGCGAAGCTCAAGGAGAGTGGTCGCGAGATTGTTCTGAAGGTTATTCGCCCTGATATTCGCCCG
GTGATTGACGCAGATCTAAAACTGATGCACCGAATGGCGCGTATAGTCGCTAAGTCGCTTCCTGAAGCACGTCGTTTGAA
ACCGGTTGAAGTCGTTCACGAGTACGAAAAAACGTTACTTGATGAACTAGACCTGCGCCGAGAGGCGGCCAATGCGATTC
AACTACGACGTAATTTTGAAGGCAGTGAAGAGCTGTATGTTCCAGAGGTTATCCCTGATCTAAGCAGCGAAACCCTGATG
GTGTCAGAGCGTATCTACGGTATTCAAGTATCCGATATTGAAACGCTAGAAGCCAACGGCACCAACATGAAATTGCTCGC
GGAACGTGGCGTGACGGTATTCTTCACCCAAGTATTCCGAGACAGCTTTTTCCATGCAGACATGCACCCGGGCAACGTAT
TCGTTAACCCAGAGAATCCAGATAACCCTCAGTGGATTGGTTTGGATTGTGGCATTGTCGGCACGCTCAACAGTGAAGAT
AAGCGCTATTTAGCAGAGAACCTGTTGGCTTTCTTTAATCGAGATTATCGTAAAGTCGCCGAGCTGCACGTTGATTCGGG
TTGGGTGCCACACGACACCAACGTCAATGATTTTGAGTTCGCGATCCGTATGGTGTGTGAGCCAATTTTTGCAAAACCAC
TTGGTGAGATCTCATTTGGCCATGTGTTGCTAAACTTATTTAATACAGCAAGACGTTTCAACATGGAGGTTCAGCCTCAG
TTGGTACTTCTACAGAAGACCTTGTTGTATGTGGAAGGGCTAGGTCGTCAGTTGTATCCGCAACTTGATTTGTGGGCAAC
CGCCAAGCCTTTCCTTGAAACCTGGATGATGAATCAGGTGGGGCCGCAAGCTGTGATCAATGCAGTAAAAGAGCGCGCGC
CATTCTGGGCAGAAAAACTGCCAGAGCTGCCAGAGCTGCTTTATGACAGCTTGCGCCAAGGTAAAGCGATGAACCACAGA
ATGGATCAGCTTTATCAAGGTTACCGAGATAGTAAGCGTCAGCAAGCAACTGGAAAGTTTTTGTTTGGCGTTGGAGCCAC
TTTAGTCGTATGCTCCGCAATATTAGTTTCAAGCCCTTATGAGCAGCTATCTATGGGCTGTGGCATCGCAGGTGTCACAT
TTTGGTTGCTTAGTTGGCGAGCTTACCGTCGTTAG

Upstream 100 bases:

>100_bases
CTGCACCGTTAGAAGTCGCGCATTTTTGCGACCAAGTTGATGACGTAAAAAGCTCTGCTGCTCGTCTTGAAGCTAAGTTG
AACGCTCTGTTGGAGAAAGC

Downstream 100 bases:

>100_bases
ACAGTAGACTCTCTTAATATTTTTTATGTGTAGACAGACCCGAGGACAATGACAATGGGTGGTATCAGTATTTGGCAACT
TCTAATCATTGCTGTAATTG

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MTPAELKRLYHIIKVQLEYGLDELMPEHQLTKAPLLARKSLFWLKNKHQDKELGHRLRLALQELGPVWIKFGQMMSTRRD
LFPPHIADQLALLQDQVAPFDGQLAKRDMEKALGGRLDNWFTDFDIEPLASASIAQVHTAKLKESGREIVLKVIRPDIRP
VIDADLKLMHRMARIVAKSLPEARRLKPVEVVHEYEKTLLDELDLRREAANAIQLRRNFEGSEELYVPEVIPDLSSETLM
VSERIYGIQVSDIETLEANGTNMKLLAERGVTVFFTQVFRDSFFHADMHPGNVFVNPENPDNPQWIGLDCGIVGTLNSED
KRYLAENLLAFFNRDYRKVAELHVDSGWVPHDTNVNDFEFAIRMVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGLGRQLYPQLDLWATAKPFLETWMMNQVGPQAVINAVKERAPFWAEKLPELPELLYDSLRQGKAMNHR
MDQLYQGYRDSKRQQATGKFLFGVGATLVVCSAILVSSPYEQLSMGCGIAGVTFWLLSWRAYRR

Sequences:

>Translated_544_residues
MTPAELKRLYHIIKVQLEYGLDELMPEHQLTKAPLLARKSLFWLKNKHQDKELGHRLRLALQELGPVWIKFGQMMSTRRD
LFPPHIADQLALLQDQVAPFDGQLAKRDMEKALGGRLDNWFTDFDIEPLASASIAQVHTAKLKESGREIVLKVIRPDIRP
VIDADLKLMHRMARIVAKSLPEARRLKPVEVVHEYEKTLLDELDLRREAANAIQLRRNFEGSEELYVPEVIPDLSSETLM
VSERIYGIQVSDIETLEANGTNMKLLAERGVTVFFTQVFRDSFFHADMHPGNVFVNPENPDNPQWIGLDCGIVGTLNSED
KRYLAENLLAFFNRDYRKVAELHVDSGWVPHDTNVNDFEFAIRMVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGLGRQLYPQLDLWATAKPFLETWMMNQVGPQAVINAVKERAPFWAEKLPELPELLYDSLRQGKAMNHR
MDQLYQGYRDSKRQQATGKFLFGVGATLVVCSAILVSSPYEQLSMGCGIAGVTFWLLSWRAYRR
>Mature_543_residues
TPAELKRLYHIIKVQLEYGLDELMPEHQLTKAPLLARKSLFWLKNKHQDKELGHRLRLALQELGPVWIKFGQMMSTRRDL
FPPHIADQLALLQDQVAPFDGQLAKRDMEKALGGRLDNWFTDFDIEPLASASIAQVHTAKLKESGREIVLKVIRPDIRPV
IDADLKLMHRMARIVAKSLPEARRLKPVEVVHEYEKTLLDELDLRREAANAIQLRRNFEGSEELYVPEVIPDLSSETLMV
SERIYGIQVSDIETLEANGTNMKLLAERGVTVFFTQVFRDSFFHADMHPGNVFVNPENPDNPQWIGLDCGIVGTLNSEDK
RYLAENLLAFFNRDYRKVAELHVDSGWVPHDTNVNDFEFAIRMVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQL
VLLQKTLLYVEGLGRQLYPQLDLWATAKPFLETWMMNQVGPQAVINAVKERAPFWAEKLPELPELLYDSLRQGKAMNHRM
DQLYQGYRDSKRQQATGKFLFGVGATLVVCSAILVSSPYEQLSMGCGIAGVTFWLLSWRAYRR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily

Homologues:

Organism=Homo sapiens, GI41393593, Length=271, Percent_Identity=29.1512915129151, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI40254938, Length=254, Percent_Identity=29.9212598425197, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI32261307, Length=315, Percent_Identity=23.8095238095238, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI217035081, Length=208, Percent_Identity=31.25, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI34147522, Length=236, Percent_Identity=30.0847457627119, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI2367309, Length=546, Percent_Identity=69.96336996337, Blast_Score=787, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=304, Percent_Identity=30.2631578947368, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17555620, Length=480, Percent_Identity=24.1666666666667, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32565180, Length=343, Percent_Identity=24.4897959183673, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325148, Length=458, Percent_Identity=24.6724890829694, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323282, Length=297, Percent_Identity=24.5791245791246, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=196, Percent_Identity=26.0204081632653, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI22024280, Length=262, Percent_Identity=28.6259541984733, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24662575, Length=275, Percent_Identity=28.7272727272727, Blast_Score=105, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIB_VIBSL (B7VHC3)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002415787.1
- GeneID:   7159775
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0100
- HOGENOM:   HBG593509
- OMA:   RIQRVVI
- ProtClustDB:   PRK04750
- HAMAP:   MF_00414
- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232
- TIGRFAMs:   TIGR01982

Pfam domain/function: PF03109 ABC1; SSF56112 Kinase_like

EC number: NA

Molecular weight: Translated: 62406; Mature: 62275

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x19598a78)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPAELKRLYHIIKVQLEYGLDELMPEHQLTKAPLLARKSLFWLKNKHQDKELGHRLRLA
CCHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LQELGPVWIKFGQMMSTRRDLFPPHIADQLALLQDQVAPFDGQLAKRDMEKALGGRLDNW
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHCC
FTDFDIEPLASASIAQVHTAKLKESGREIVLKVIRPDIRPVIDADLKLMHRMARIVAKSL
CCCCCCCHHCCHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
PEARRLKPVEVVHEYEKTLLDELDLRREAANAIQLRRNFEGSEELYVPEVIPDLSSETLM
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHCCCCCCCEEE
VSERIYGIQVSDIETLEANGTNMKLLAERGVTVFFTQVFRDSFFHADMHPGNVFVNPENP
EEHHEEEEEECCCCEEECCCCCEEEHHHCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCC
DNPQWIGLDCGIVGTLNSEDKRYLAENLLAFFNRDYRKVAELHVDSGWVPHDTNVNDFEF
CCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
AIRMVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCC
QLDLWATAKPFLETWMMNQVGPQAVINAVKERAPFWAEKLPELPELLYDSLRQGKAMNHR
CCHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHCCCHHHHH
MDQLYQGYRDSKRQQATGKFLFGVGATLVVCSAILVSSPYEQLSMGCGIAGVTFWLLSWR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHH
AYRR
HHCH
>Mature Secondary Structure 
TPAELKRLYHIIKVQLEYGLDELMPEHQLTKAPLLARKSLFWLKNKHQDKELGHRLRLA
CHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LQELGPVWIKFGQMMSTRRDLFPPHIADQLALLQDQVAPFDGQLAKRDMEKALGGRLDNW
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHCC
FTDFDIEPLASASIAQVHTAKLKESGREIVLKVIRPDIRPVIDADLKLMHRMARIVAKSL
CCCCCCCHHCCHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
PEARRLKPVEVVHEYEKTLLDELDLRREAANAIQLRRNFEGSEELYVPEVIPDLSSETLM
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHCCCCCCCEEE
VSERIYGIQVSDIETLEANGTNMKLLAERGVTVFFTQVFRDSFFHADMHPGNVFVNPENP
EEHHEEEEEECCCCEEECCCCCEEEHHHCCCHHHHHHHHHHHHCCCCCCCCEEEECCCCC
DNPQWIGLDCGIVGTLNSEDKRYLAENLLAFFNRDYRKVAELHVDSGWVPHDTNVNDFEF
CCCCEEEEECCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
AIRMVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCC
QLDLWATAKPFLETWMMNQVGPQAVINAVKERAPFWAEKLPELPELLYDSLRQGKAMNHR
CCHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHCCCHHHHH
MDQLYQGYRDSKRQQATGKFLFGVGATLVVCSAILVSSPYEQLSMGCGIAGVTFWLLSWR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHH
AYRR
HHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA