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The map label for this gene is gor [H]

Identifier: 218708148

GI number: 218708148

Start: 73159

End: 74526

Strand: Reverse

Name: gor [H]

Synonym: VS_0082

Alternate gene names: 218708148

Gene position: 74526-73159 (Counterclockwise)

Preceding gene: 218708149

Following gene: 218708147

Centisome position: 2.26

GC content: 47.66

Gene sequence:

>1368_bases
ATGGAGAAAGTAATGGCGACTCATTTTGATTACATCTGTATCGGCGGCGGTTCAGGCGGCATCGCATCAGCTAACCGCGC
AGCAATGCACGGTGCAAAAGTTGCACTTATCGAAGCTCAAGACCTTGGTGGTACTTGTGTAAACGTTGGTTGTGTTCCTA
AAAAGGTTATGTGGCACGGTGCTCAAGTTGCTGAAGCGATCAACCTATATTCAAAAGACTACGGCTTCGACGTTGACGTA
AAAGGCTTCAACTGGGGCAAACTGGTTGAAAACCGCCAAGCGTACATTGGTCGTATCCACCAATCTTACGATCGTGTTCT
TGGTAACAACAAAATAAACGTAATCAAAGGCTTTGCTAAGTTTATTGATGAAAAAACCGTTGAAGTTAACGGTGAACACT
ACACTGCAGATCACATCCTGATCGCAGTAGGTGGTCGTCCAACCATTCCAAACATCCCTGGCGCAGAGCACGGTATCGAC
TCAAACGGTTTCTTCGACCTGATGGAGCAACCTAAACGTGTTGCTGTTATCGGCGCGGGCTACATCGCAGTAGAAATCGC
AGGCGTACTAAGTGCACTTGGCACAGAGACACACTTGTTCTGTCGTAAAGAGTCACCACTTCGCAGCTTCGACCCAATGA
TCGTAGAAACACTGGTTGAAGTAATGGAAGCGGAAGGTCCAACACTTCACACGCACTCAGTTCCTAAAGAAATAGTGAAA
GAAGCAGATGGCACACTGACTCTGCACCTAGAGAACGGCAACACTCAAAACGTTGACCACCTAATCTGGGCTATCGGCCG
TCACCCAGCCACTGACGCTATCAACCTAGCATCAACTGGCGTTGCAACTAACGACCGTGGCTACATCAAAGTAGACGAGT
TCCAAGCAACCAACGTTCCTGGCATCTACTGTGTTGGTGACATCATGGAAGGCGGTATCGAGCTAACACCTGTTGCTGTT
AAAGCAGGTCGCCAGCTTTCTGAGCGTCTATTCAACGGTCAAACAAACGCAAAGATGGACTACACGCTAGTACCTACTGT
TGTATTCAGCCACCCACCTATCGGCACTATTGGTCTAACGACTCAAGAAGCTGAAGAGCAATACGGCAAAGACAACATCA
AGGTATACACGTCTGGTTTTACTGCAATGTACACAGCAGTCACTCAGCACCGTCAACCTTGTAAGATGAAGCTAGTATGT
GCTGGTGAAGAAGAGACTGTAGTTGGCCTACACGGTATCGGTTTCACTGTTGATGAAATGATTCAAGGCTTCGGCGTTGC
AATGAAAATGGGCGCAACCAAAGCAGATTTCGACTCTGTTGTGGCGATTCACCCAACGGGCAGCGAAGAATTCGTTACCA
TGCGATAA

Upstream 100 bases:

>100_bases
TGAGTTCAACCGATCTGCCCTCAATATAATAATTAGACAATTTAAGAATCTATAGGACGTAGGTGTTCAGTGCGCTCACT
GTACCCACAGCCTTCAATAA

Downstream 100 bases:

>100_bases
ACCACTGTAAGTCAAAGAAATATTATACAAAAGCCGACCTATGTCGGCTTTTTTTGTTTTTTACCGTATGGTTGGGATAT
TTATTAACCGAACAGCATTT

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MEKVMATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQVAEAINLYSKDYGFDVDV
KGFNWGKLVENRQAYIGRIHQSYDRVLGNNKINVIKGFAKFIDEKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGID
SNGFFDLMEQPKRVAVIGAGYIAVEIAGVLSALGTETHLFCRKESPLRSFDPMIVETLVEVMEAEGPTLHTHSVPKEIVK
EADGTLTLHLENGNTQNVDHLIWAIGRHPATDAINLASTGVATNDRGYIKVDEFQATNVPGIYCVGDIMEGGIELTPVAV
KAGRQLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLTTQEAEEQYGKDNIKVYTSGFTAMYTAVTQHRQPCKMKLVC
AGEEETVVGLHGIGFTVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR

Sequences:

>Translated_455_residues
MEKVMATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQVAEAINLYSKDYGFDVDV
KGFNWGKLVENRQAYIGRIHQSYDRVLGNNKINVIKGFAKFIDEKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGID
SNGFFDLMEQPKRVAVIGAGYIAVEIAGVLSALGTETHLFCRKESPLRSFDPMIVETLVEVMEAEGPTLHTHSVPKEIVK
EADGTLTLHLENGNTQNVDHLIWAIGRHPATDAINLASTGVATNDRGYIKVDEFQATNVPGIYCVGDIMEGGIELTPVAV
KAGRQLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLTTQEAEEQYGKDNIKVYTSGFTAMYTAVTQHRQPCKMKLVC
AGEEETVVGLHGIGFTVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR
>Mature_455_residues
MEKVMATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQDLGGTCVNVGCVPKKVMWHGAQVAEAINLYSKDYGFDVDV
KGFNWGKLVENRQAYIGRIHQSYDRVLGNNKINVIKGFAKFIDEKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGID
SNGFFDLMEQPKRVAVIGAGYIAVEIAGVLSALGTETHLFCRKESPLRSFDPMIVETLVEVMEAEGPTLHTHSVPKEIVK
EADGTLTLHLENGNTQNVDHLIWAIGRHPATDAINLASTGVATNDRGYIKVDEFQATNVPGIYCVGDIMEGGIELTPVAV
KAGRQLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLTTQEAEEQYGKDNIKVYTSGFTAMYTAVTQHRQPCKMKLVC
AGEEETVVGLHGIGFTVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=461, Percent_Identity=51.8438177874187, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=37.6906318082789, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI148277065, Length=456, Percent_Identity=35.7456140350877, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI33519430, Length=456, Percent_Identity=35.7456140350877, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519428, Length=456, Percent_Identity=35.7456140350877, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI33519426, Length=456, Percent_Identity=35.7456140350877, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI148277071, Length=456, Percent_Identity=35.7456140350877, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI291045266, Length=481, Percent_Identity=33.4719334719335, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI291045268, Length=481, Percent_Identity=30.3534303534304, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI91199540, Length=461, Percent_Identity=28.8503253796095, Blast_Score=148, Evalue=9e-36,
Organism=Escherichia coli, GI1789915, Length=451, Percent_Identity=68.5144124168514, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=446, Percent_Identity=28.0269058295964, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=27.2727272727273, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87081717, Length=460, Percent_Identity=26.304347826087, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787114, Length=202, Percent_Identity=30.6930693069307, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=54.2222222222222, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=54.2222222222222, Blast_Score=438, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=35.4430379746835, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=34.5114345114345, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=29.8701298701299, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=49.3534482758621, Blast_Score=422, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=27.741935483871, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325240, Length=479, Percent_Identity=22.3382045929019, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24640549, Length=469, Percent_Identity=39.2324093816631, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24640553, Length=469, Percent_Identity=39.2324093816631, Blast_Score=285, Evalue=6e-77,
Organism=Drosophila melanogaster, GI24640551, Length=469, Percent_Identity=39.2324093816631, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI17737741, Length=471, Percent_Identity=37.1549893842887, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI21358499, Length=465, Percent_Identity=29.0322580645161, Blast_Score=155, Evalue=4e-38,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49139; Mature: 49139

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVMATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQDLGGTCVNVGCVPKKVMWHG
CCCCEEECCCEEEEECCCCCCCCCCHHHHCCCEEEEEEECCCCCEEEEECCCCHHHHHCC
AQVAEAINLYSKDYGFDVDVKGFNWGKLVENRQAYIGRIHQSYDRVLGNNKINVIKGFAK
HHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FIDEKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGIDSNGFFDLMEQPKRVAVIGAG
HHCCCEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEECC
YIAVEIAGVLSALGTETHLFCRKESPLRSFDPMIVETLVEVMEAEGPTLHTHSVPKEIVK
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHH
EADGTLTLHLENGNTQNVDHLIWAIGRHPATDAINLASTGVATNDRGYIKVDEFQATNVP
HCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEHHCCCCEECCCCEEEEECEECCCCC
GIYCVGDIMEGGIELTPVAVKAGRQLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLT
CEEEEHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECEEEECCCCCCEEECC
TQEAEEQYGKDNIKVYTSGFTAMYTAVTQHRQPCKMKLVCAGEEETVVGLHGIGFTVDEM
CHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCHHHH
IQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR
HHHCCCEEECCCCCCCCCCEEEEECCCCCCEEEEC
>Mature Secondary Structure
MEKVMATHFDYICIGGGSGGIASANRAAMHGAKVALIEAQDLGGTCVNVGCVPKKVMWHG
CCCCEEECCCEEEEECCCCCCCCCCHHHHCCCEEEEEEECCCCCEEEEECCCCHHHHHCC
AQVAEAINLYSKDYGFDVDVKGFNWGKLVENRQAYIGRIHQSYDRVLGNNKINVIKGFAK
HHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
FIDEKTVEVNGEHYTADHILIAVGGRPTIPNIPGAEHGIDSNGFFDLMEQPKRVAVIGAG
HHCCCEEEECCCEEEECEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEECC
YIAVEIAGVLSALGTETHLFCRKESPLRSFDPMIVETLVEVMEAEGPTLHTHSVPKEIVK
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCHHHHHH
EADGTLTLHLENGNTQNVDHLIWAIGRHPATDAINLASTGVATNDRGYIKVDEFQATNVP
HCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEHHCCCCEECCCCEEEEECEECCCCC
GIYCVGDIMEGGIELTPVAVKAGRQLSERLFNGQTNAKMDYTLVPTVVFSHPPIGTIGLT
CEEEEHHHHHCCEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECEEEECCCCCCEEECC
TQEAEEQYGKDNIKVYTSGFTAMYTAVTQHRQPCKMKLVCAGEEETVVGLHGIGFTVDEM
CHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCCHHHH
IQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR
HHHCCCEEECCCCCCCCCCEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521741; 8041620; 9278503; 2006135; 8061609 [H]