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The map label for this gene is yhdH [H]

Identifier: 218708126

GI number: 218708126

Start: 36278

End: 37258

Strand: Reverse

Name: yhdH [H]

Synonym: VS_0039

Alternate gene names: 218708126

Gene position: 37258-36278 (Counterclockwise)

Preceding gene: 218708127

Following gene: 218708124

Centisome position: 1.13

GC content: 46.48

Gene sequence:

>981_bases
ATGTTTAAAGCACTTGTACTAAACCAAGAAGACAAAAAAACTATCGCGTCAGTTTCTCAAATTGAAGAGTCTCAATTACC
AGAAGGTAACGTGAAGATCGATGTTAGCTACTCTTCTTTGAACTACAAAGATGGTTTGGCGATTACAGGTAAAGGGCGCA
TTGTTCGTAACTTCCCTATGGTTCCTGGTATCGACCTTTCAGGTGTGGTTTCACAATCTGATGACCCACGCTACAAAGCA
GGCGACGAAGTTGTGCTAACGGGTTGGGGTGTTGGTGAAGGTCACTGGGGCGGCATGGCTGAAAAAGCGAGCCTAAACGG
TGATTGGTTAGTGCCAATGCCAGCAGGTCTAGATGCTAAGAAAGTCATGGCAATCGGTACAGCAGGCTTCACAGCAATGC
TTTGTGTGCAAGCTATCGTAGATGCAGGCATCAAACCAGAAGACGGTGAAATCCTAGTAACGGGTGCTAGTGGCGGCGTA
GGTAGCGTATCTATCACTCTACTAAACCAACTGGGCTACAAAGTGGCAGCAGTGACTGGCCGTGCTTCTGTAAACGGTGA
ACTACTTAAATCACTAGGCGCGACACGTATTGTAGAGCGTGCTGAACTAGAAGAACCAGCTAAGCCACTAGAGAAACAAC
TGTGGGCTGGCGCTATCGATACAGTAGGCAGCAAAGTGCTTGCGAAAGTATTGGCGCAAATTGATTACAACGGTGCGGTT
GCAATGTGTGGTCTAGCAGGCGGTTTTGACTTACCAACTACAGTAATGCCATTCATTCTACGTAACGTTCGCCTACAAGG
TGTGGATTCAGTAATGTGCCCTCGTGAAAAACGTATTAAAGCGTGGGAACAACTGGCTGAATTACTACCTGAGTCTTTCT
ACGGCCAAGCGACTAAAGAAGTGTCTTTAGATGGCGCAATTCAAGCTGCGGAAGACATCACTAACGGTCAAATCACTGGT
CGCGTAGTTATTAAACTGTAA

Upstream 100 bases:

>100_bases
CATAAAACGCATATATTCAATGTTGATGTTTCATTATTTTTTCTCAGATGATTCAACTAAAGTTACTTCAGTTTCCTAAT
ATTCCTCCACGGAGCAGATC

Downstream 100 bases:

>100_bases
TTGAAAATTAAACTTCCGTAACCCAGAATAACAAAGGGCTGATAGTAATCAGCCCTTTTGCGTTTTTGTCATTTGGATCG
AGTAAACTAAAGCGAGATCT

Product: Zinc-binding dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MFKALVLNQEDKKTIASVSQIEESQLPEGNVKIDVSYSSLNYKDGLAITGKGRIVRNFPMVPGIDLSGVVSQSDDPRYKA
GDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPAGLDAKKVMAIGTAGFTAMLCVQAIVDAGIKPEDGEILVTGASGGV
GSVSITLLNQLGYKVAAVTGRASVNGELLKSLGATRIVERAELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQIDYNGAV
AMCGLAGGFDLPTTVMPFILRNVRLQGVDSVMCPREKRIKAWEQLAELLPESFYGQATKEVSLDGAIQAAEDITNGQITG
RVVIKL

Sequences:

>Translated_326_residues
MFKALVLNQEDKKTIASVSQIEESQLPEGNVKIDVSYSSLNYKDGLAITGKGRIVRNFPMVPGIDLSGVVSQSDDPRYKA
GDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPAGLDAKKVMAIGTAGFTAMLCVQAIVDAGIKPEDGEILVTGASGGV
GSVSITLLNQLGYKVAAVTGRASVNGELLKSLGATRIVERAELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQIDYNGAV
AMCGLAGGFDLPTTVMPFILRNVRLQGVDSVMCPREKRIKAWEQLAELLPESFYGQATKEVSLDGAIQAAEDITNGQITG
RVVIKL
>Mature_326_residues
MFKALVLNQEDKKTIASVSQIEESQLPEGNVKIDVSYSSLNYKDGLAITGKGRIVRNFPMVPGIDLSGVVSQSDDPRYKA
GDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPAGLDAKKVMAIGTAGFTAMLCVQAIVDAGIKPEDGEILVTGASGGV
GSVSITLLNQLGYKVAAVTGRASVNGELLKSLGATRIVERAELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQIDYNGAV
AMCGLAGGFDLPTTVMPFILRNVRLQGVDSVMCPREKRIKAWEQLAELLPESFYGQATKEVSLDGAIQAAEDITNGQITG
RVVIKL

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789651, Length=325, Percent_Identity=67.0769230769231, Blast_Score=454, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR014188 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.1

Molecular weight: Translated: 34426; Mature: 34426

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKALVLNQEDKKTIASVSQIEESQLPEGNVKIDVSYSSLNYKDGLAITGKGRIVRNFPM
CCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEECCCEEEEECCC
VPGIDLSGVVSQSDDPRYKAGDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPAGLDAK
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCHH
KVMAIGTAGFTAMLCVQAIVDAGIKPEDGEILVTGASGGVGSVSITLLNQLGYKVAAVTG
HEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEEC
RASVNGELLKSLGATRIVERAELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQIDYNGAV
CCCCCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
AMCGLAGGFDLPTTVMPFILRNVRLQGVDSVMCPREKRIKAWEQLAELLPESFYGQATKE
EEEECCCCCCCHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHCCHHHCCCCCCE
VSLDGAIQAAEDITNGQITGRVVIKL
ECCCHHHHHHHHCCCCEEEEEEEEEC
>Mature Secondary Structure
MFKALVLNQEDKKTIASVSQIEESQLPEGNVKIDVSYSSLNYKDGLAITGKGRIVRNFPM
CCEEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEEECCCEEEEECCC
VPGIDLSGVVSQSDDPRYKAGDEVVLTGWGVGEGHWGGMAEKASLNGDWLVPMPAGLDAK
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCCHH
KVMAIGTAGFTAMLCVQAIVDAGIKPEDGEILVTGASGGVGSVSITLLNQLGYKVAAVTG
HEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEEC
RASVNGELLKSLGATRIVERAELEEPAKPLEKQLWAGAIDTVGSKVLAKVLAQIDYNGAV
CCCCCHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
AMCGLAGGFDLPTTVMPFILRNVRLQGVDSVMCPREKRIKAWEQLAELLPESFYGQATKE
EEEECCCCCCCHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHHHHHCCHHHCCCCCCE
VSLDGAIQAAEDITNGQITGRVVIKL
ECCCHHHHHHHHCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1370469; 9278503 [H]