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The map label for this gene is phoQ [H]

Identifier: 218708118

GI number: 218708118

Start: 27867

End: 29249

Strand: Reverse

Name: phoQ [H]

Synonym: VS_0030

Alternate gene names: 218708118

Gene position: 29249-27867 (Counterclockwise)

Preceding gene: 218708119

Following gene: 218708103

Centisome position: 0.89

GC content: 41.94

Gene sequence:

>1383_bases
ATGAAAAGACTGTACAAAACTCAGTTCAGACGTCGGACATTCGCCGTTGCTGCTTCCATTATGATTTCAATGGTACTCAC
TAGCGCCTGGTTCTACTACAACAGTCAAAAACACCAACTTTTTGAGTACTACTCGAAAAATACCCTTCGAGAATTGCCTG
CTGTAATCAATGAACTGCTGTCTTCTGGGGAAATACCGCCATTGACGGAGTGGGATAGGTTCTATGCGAAAGAGTCTCCC
AACACTAGCGTCACTCTATGTGATCACAACAATCAACAAGTATGGACATCAGTAAATATTGAAAGACGAGCTAAGCTGCT
ATCAGAGATAGGCGTCAGCCAATCTCAAGTCAACGAACTGTGTCATGATCTAAATTTCCCCATAGATACTATTCGTTTGG
TTGAAAGACCGAATGGCGCCGCTTTTATTGTCCACACAATTCTCTGGAAAGGTTTCCAGGAAAAAAAAGATGGCAGAGTT
ATCTTTACCCAAAGGGTCGAAGAGAAAATAGAACCCATACATCAGTTAAAATACACCGCGGTTGGAGTGTTAGTGGTTGC
GCTTGCTTTGATCAGTGCTCTACTTTTGGTTTTTTATCGTATTAGTTTTGCGCCGTTTACTCGACTAGAGAATGAACTGA
ATGACATAAAGCAGGGTAAACAAAACCAATTAGCCCAGTCATACCCTGAAGATTTACATAGCGTCACCAGTGCATTGAAC
GAATTGCTATACCAACAAAAAGAAAATCAGGAGCGTTATAAGCGTTCTCTCAATGATCTCGCCCATAGTTTGAAGACTCG
CGTGACAGTTTCTCAAGCATTGCTTGATGAAGACTCATCCAAAACAAAGAATGACCAAATCAACCAACAACTGTTAGAAA
TGGATAGCTTAATTCAGGCACAACTCAAAAGGGCTTCGCTAGGCGTTAAAGGTATAACGACTTCATCGACACCGATAAAA
CCAATCCTCGACAGCCTAGTAGGCATGTTTACGAAAATCCATGCCGACAAAAAGATCCAATTCATCACTCAGTTTGACGA
CCAACAGACCGTGCCTCTTAATAAAGATGATCTTATGGAAGTGCTCGGTAACCTATTAGAAAATACTTATCGGTTCGCAC
AAACCTCTATCGAATTCAAAGCCACTCAAAGCGAACAGCAAATCTTGATTGAGATCTATAATGATGGGCCAGTAATAGAT
AGCTCGATCAGCCAAACCTTATTTCAACGTGGCGTAAGAGCCGATCAGAAGACCCATGGTACGGGGTTAGGTTTGGCGCT
ATGTGATGAGATACTCCATAGCTACAAAGGGACAATCTGGTTTGAGCAATCAGATAACCCATCCGTGGGTGTCGTTTTAA
AAATACTGCTCCCAACAAGTTAA

Upstream 100 bases:

>100_bases
GTTTCACGCTTACGTAAAAAGTTAACGCAATACACTCAAGCTAAGCTGATCAGCACCATTCGCGGGCAAGGTTATCGTTT
TGAACTAGAAGCCAAGTAGT

Downstream 100 bases:

>100_bases
ATTTGTAGGGCAGGGTTAAGAGTGCATATCAACCCTGCGATTGTTATGGCGACCGGATTCAGTCTCGTTACTCTGCACTG
GGTTCGCCTCACCTTGTGAA

Product: putative sensor protein phoQ,membrane-associated histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKRLYKTQFRRRTFAVAASIMISMVLTSAWFYYNSQKHQLFEYYSKNTLRELPAVINELLSSGEIPPLTEWDRFYAKESP
NTSVTLCDHNNQQVWTSVNIERRAKLLSEIGVSQSQVNELCHDLNFPIDTIRLVERPNGAAFIVHTILWKGFQEKKDGRV
IFTQRVEEKIEPIHQLKYTAVGVLVVALALISALLLVFYRISFAPFTRLENELNDIKQGKQNQLAQSYPEDLHSVTSALN
ELLYQQKENQERYKRSLNDLAHSLKTRVTVSQALLDEDSSKTKNDQINQQLLEMDSLIQAQLKRASLGVKGITTSSTPIK
PILDSLVGMFTKIHADKKIQFITQFDDQQTVPLNKDDLMEVLGNLLENTYRFAQTSIEFKATQSEQQILIEIYNDGPVID
SSISQTLFQRGVRADQKTHGTGLGLALCDEILHSYKGTIWFEQSDNPSVGVVLKILLPTS

Sequences:

>Translated_460_residues
MKRLYKTQFRRRTFAVAASIMISMVLTSAWFYYNSQKHQLFEYYSKNTLRELPAVINELLSSGEIPPLTEWDRFYAKESP
NTSVTLCDHNNQQVWTSVNIERRAKLLSEIGVSQSQVNELCHDLNFPIDTIRLVERPNGAAFIVHTILWKGFQEKKDGRV
IFTQRVEEKIEPIHQLKYTAVGVLVVALALISALLLVFYRISFAPFTRLENELNDIKQGKQNQLAQSYPEDLHSVTSALN
ELLYQQKENQERYKRSLNDLAHSLKTRVTVSQALLDEDSSKTKNDQINQQLLEMDSLIQAQLKRASLGVKGITTSSTPIK
PILDSLVGMFTKIHADKKIQFITQFDDQQTVPLNKDDLMEVLGNLLENTYRFAQTSIEFKATQSEQQILIEIYNDGPVID
SSISQTLFQRGVRADQKTHGTGLGLALCDEILHSYKGTIWFEQSDNPSVGVVLKILLPTS
>Mature_460_residues
MKRLYKTQFRRRTFAVAASIMISMVLTSAWFYYNSQKHQLFEYYSKNTLRELPAVINELLSSGEIPPLTEWDRFYAKESP
NTSVTLCDHNNQQVWTSVNIERRAKLLSEIGVSQSQVNELCHDLNFPIDTIRLVERPNGAAFIVHTILWKGFQEKKDGRV
IFTQRVEEKIEPIHQLKYTAVGVLVVALALISALLLVFYRISFAPFTRLENELNDIKQGKQNQLAQSYPEDLHSVTSALN
ELLYQQKENQERYKRSLNDLAHSLKTRVTVSQALLDEDSSKTKNDQINQQLLEMDSLIQAQLKRASLGVKGITTSSTPIK
PILDSLVGMFTKIHADKKIQFITQFDDQQTVPLNKDDLMEVLGNLLENTYRFAQTSIEFKATQSEQQILIEIYNDGPVID
SSISQTLFQRGVRADQKTHGTGLGLALCDEILHSYKGTIWFEQSDNPSVGVVLKILLPTS

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=385, Percent_Identity=25.7142857142857, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=25.5639097744361, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788393, Length=271, Percent_Identity=23.6162361623616, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52446; Mature: 52446

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLYKTQFRRRTFAVAASIMISMVLTSAWFYYNSQKHQLFEYYSKNTLRELPAVINELL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SSGEIPPLTEWDRFYAKESPNTSVTLCDHNNQQVWTSVNIERRAKLLSEIGVSQSQVNEL
HCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCHHHHHHH
CHDLNFPIDTIRLVERPNGAAFIVHTILWKGFQEKKDGRVIFTQRVEEKIEPIHQLKYTA
HHHCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
VGVLVVALALISALLLVFYRISFAPFTRLENELNDIKQGKQNQLAQSYPEDLHSVTSALN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHH
ELLYQQKENQERYKRSLNDLAHSLKTRVTVSQALLDEDSSKTKNDQINQQLLEMDSLIQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
QLKRASLGVKGITTSSTPIKPILDSLVGMFTKIHADKKIQFITQFDDQQTVPLNKDDLME
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHH
VLGNLLENTYRFAQTSIEFKATQSEQQILIEIYNDGPVIDSSISQTLFQRGVRADQKTHG
HHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCC
TGLGLALCDEILHSYKGTIWFEQSDNPSVGVVLKILLPTS
CCCHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MKRLYKTQFRRRTFAVAASIMISMVLTSAWFYYNSQKHQLFEYYSKNTLRELPAVINELL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SSGEIPPLTEWDRFYAKESPNTSVTLCDHNNQQVWTSVNIERRAKLLSEIGVSQSQVNEL
HCCCCCCCCHHHHHHHCCCCCCEEEEEECCCCEEEEECCHHHHHHHHHHHCCCHHHHHHH
CHDLNFPIDTIRLVERPNGAAFIVHTILWKGFQEKKDGRVIFTQRVEEKIEPIHQLKYTA
HHHCCCCHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
VGVLVVALALISALLLVFYRISFAPFTRLENELNDIKQGKQNQLAQSYPEDLHSVTSALN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHHH
ELLYQQKENQERYKRSLNDLAHSLKTRVTVSQALLDEDSSKTKNDQINQQLLEMDSLIQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
QLKRASLGVKGITTSSTPIKPILDSLVGMFTKIHADKKIQFITQFDDQQTVPLNKDDLME
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHH
VLGNLLENTYRFAQTSIEFKATQSEQQILIEIYNDGPVIDSSISQTLFQRGVRADQKTHG
HHHHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCC
TGLGLALCDEILHSYKGTIWFEQSDNPSVGVVLKILLPTS
CCCHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA