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The map label for this gene is phoP [H]

Identifier: 218708119

GI number: 218708119

Start: 29251

End: 29931

Strand: Reverse

Name: phoP [H]

Synonym: VS_0031

Alternate gene names: 218708119

Gene position: 29931-29251 (Counterclockwise)

Preceding gene: 218708120

Following gene: 218708118

Centisome position: 0.91

GC content: 42.44

Gene sequence:

>681_bases
ATGCTGGTTGTTTTGGTTGAAGATAATGAAATATTGAATCACCACCTATCTTCTCAGCTCAGTGAGCAAGGACATACTGT
CCATGCAGATAGAACAGCTTCTGCATGTTTACAAACGATTCAAAAACAGTCCAATACAGATGTGATGATCATTGACCTTG
GCCTCCCTGACTTTGATGGCATTACGCTGATCAAGCAAATACGTCGTAAAGAAATTGCAGTCCCAATATTAATCTTAACC
GCACGTGGCAACTGGCAAGATAAAGTAGAAGGGCTTAACTCCGGGGCTGATGATTACCTTACCAAGCCCTTCCAATTTGA
AGAGCTACACGCTCGCCTTGAGGCGCTTGTTCGTCGCAATCAAGGGTTTTCCGCTTCCCAAATCAAAGCGCAATCGCTCA
CCTTAGACACTCAAGCCAAACGTATCAGTTACGATGATGCTCTGATTGAACTTACAGCCTTAGAATTTCAAATATTCGAG
TACTTAATTCGCCATTGCTTACAAATCGTATCTAAACAACAAATCGCAGACTCCCTTTATGCGCAGGGTGAAAATGTTCA
GCTAAACAATATTGAGGTTATCGTTTCACGCTTACGTAAAAAGTTAACGCAATACACTCAAGCTAAGCTGATCAGCACCA
TTCGCGGGCAAGGTTATCGTTTTGAACTAGAAGCCAAGTAG

Upstream 100 bases:

>100_bases
GAATAAATATTAAGGGGGAAGCTTTGGCTTCTCCCTTTTTTTTATCCAAAGCTAGTGTAAGCTCTATCTGGTTGAATATT
ATTGTAGATAGGGATATTAC

Downstream 100 bases:

>100_bases
TATGAAAAGACTGTACAAAACTCAGTTCAGACGTCGGACATTCGCCGTTGCTGCTTCCATTATGATTTCAATGGTACTCA
CTAGCGCCTGGTTCTACTAC

Product: DNA-binding response regulator PhoP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MLVVLVEDNEILNHHLSSQLSEQGHTVHADRTASACLQTIQKQSNTDVMIIDLGLPDFDGITLIKQIRRKEIAVPILILT
ARGNWQDKVEGLNSGADDYLTKPFQFEELHARLEALVRRNQGFSASQIKAQSLTLDTQAKRISYDDALIELTALEFQIFE
YLIRHCLQIVSKQQIADSLYAQGENVQLNNIEVIVSRLRKKLTQYTQAKLISTIRGQGYRFELEAK

Sequences:

>Translated_226_residues
MLVVLVEDNEILNHHLSSQLSEQGHTVHADRTASACLQTIQKQSNTDVMIIDLGLPDFDGITLIKQIRRKEIAVPILILT
ARGNWQDKVEGLNSGADDYLTKPFQFEELHARLEALVRRNQGFSASQIKAQSLTLDTQAKRISYDDALIELTALEFQIFE
YLIRHCLQIVSKQQIADSLYAQGENVQLNNIEVIVSRLRKKLTQYTQAKLISTIRGQGYRFELEAK
>Mature_226_residues
MLVVLVEDNEILNHHLSSQLSEQGHTVHADRTASACLQTIQKQSNTDVMIIDLGLPDFDGITLIKQIRRKEIAVPILILT
ARGNWQDKVEGLNSGADDYLTKPFQFEELHARLEALVRRNQGFSASQIKAQSLTLDTQAKRISYDDALIELTALEFQIFE
YLIRHCLQIVSKQQIADSLYAQGENVQLNNIEVIVSRLRKKLTQYTQAKLISTIRGQGYRFELEAK

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=45.0892857142857, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=34.2222222222222, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=31.8385650224215, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=34.6846846846847, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=33.9366515837104, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=34.5454545454545, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=32, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=29.7777777777778, Blast_Score=103, Evalue=6e-24,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=29.0748898678414, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=31.0043668122271, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=29.1304347826087, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=27.5109170305677, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=26.271186440678, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=34.5132743362832, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790299, Length=113, Percent_Identity=30.0884955752212, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25676; Mature: 25676

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVVLVEDNEILNHHLSSQLSEQGHTVHADRTASACLQTIQKQSNTDVMIIDLGLPDFDG
CEEEEECCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
ITLIKQIRRKEIAVPILILTARGNWQDKVEGLNSGADDYLTKPFQFEELHARLEALVRRN
HHHHHHHHHHHCCEEEEEEEECCCCHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHC
QGFSASQIKAQSLTLDTQAKRISYDDALIELTALEFQIFEYLIRHCLQIVSKQQIADSLY
CCCCHHHHHHHHEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGENVQLNNIEVIVSRLRKKLTQYTQAKLISTIRGQGYRFELEAK
HCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MLVVLVEDNEILNHHLSSQLSEQGHTVHADRTASACLQTIQKQSNTDVMIIDLGLPDFDG
CEEEEECCCHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
ITLIKQIRRKEIAVPILILTARGNWQDKVEGLNSGADDYLTKPFQFEELHARLEALVRRN
HHHHHHHHHHHCCEEEEEEEECCCCHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHC
QGFSASQIKAQSLTLDTQAKRISYDDALIELTALEFQIFEYLIRHCLQIVSKQQIADSLY
CCCCHHHHHHHHEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQGENVQLNNIEVIVSRLRKKLTQYTQAKLISTIRGQGYRFELEAK
HCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA