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The map label for this gene is dxs [H]

Identifier: 218703703

GI number: 218703703

Start: 497031

End: 498893

Strand: Reverse

Name: dxs [H]

Synonym: ECUMN_0459

Alternate gene names: 218703703

Gene position: 498893-497031 (Counterclockwise)

Preceding gene: 218703704

Following gene: 218703702

Centisome position: 9.59

GC content: 53.95

Gene sequence:

>1863_bases
ATGAGTTTTGATATTGCCAAATACCCGACCCTGGCACTGGTCGACTCCACCCAGGAGTTACGACTGTTGCCGAAAGAGAG
TTTACCGAAACTCTGCGACGAACTGCGCCGCTATTTACTCGACAGCGTGAGCCGTTCCAGCGGGCACTTCGCCTCCGGGC
TGGGCACGGTCGAACTGACCGTGGCGCTGCACTATGTCTACAACACCCCGTTTGACCAATTGATTTGGGATGTGGGGCAT
CAGGCTTATCCGCATAAAATTTTGACCGGACGCCGCGACAAAATCGGCACCATCCGTCAGAAAGGCGGCCTGCACCCGTT
CCCGTGGCGCGGCGAGAGCGAATATGACGTATTAAGCGTCGGGCATTCATCAACCTCCATCAGTGCCGGAATTGGTATTG
CGGTTGCTGCCGAGAAAGAAGGCAAAAATCGCCGTACCGTCTGTGTCATTGGCGATGGCGCTATTACCGCTGGCATGGCG
TTTGAAGCGATGAATCACGCGGGCGATATCCGTCCTGATATGCTGGTGGTTCTCAACGACAATGAAATGTCGATTTCCGA
AAATGTTGGCGCGCTCAACAACCATCTGGCGCAACTGCTTTCCGGTAAGCTTTACTCTTCACTGCGCGAAGGCGGGAAAA
AAGTTTTCTCTGGCGTGCCCCCCATTAAAGAGCTGCTCAAACGTACCGAAGAACATATTAAAGGCATGGTAGTGCCTGGC
ACGTTGTTTGAAGAGCTGGGCTTTAACTACATCGGCCCGGTTGACGGTCACGATGTGCTGGGGCTTATCACTACGCTTAA
GAACATGCGCGACCTGAAAGGACCGCAGTTCCTGCATATCATGACCAAAAAAGGTCGTGGTTATGAACCGGCAGAAAAAG
ACCCAATCACCTTCCACGCCGTGCCTAAATTTGATCCCTCCAGCGGTTGTTTGCCGAAAAGTAGCGGCGGTTTGCCGAGC
TATTCAAAAATCTTTGGCGACTGGTTGTGCGAAACGGCGGCGAAAGATAACAAGCTGATGGCGATTACTCCGGCGATGCG
TGAAGGTTCCGGCATGGTCGAGTTTTCACGTAAATTCCCGGATCGCTACTTCGACGTGGCAATTGCCGAGCAACACGCAG
TGACCTTTGCGGCGGGTCTGGCGATTGGTGGCTACAAACCCGTTGTCGCGATCTACTCCACTTTCCTGCAACGCGCCTAT
GATCAGGTGCTGCATGACGTGGCAATTCAAAAGCTTCCGGTCCTGTTCGCAATCGACCGCGCGGGCATTGTTGGTGCTGA
TGGTCAAACCCACCAGGGCGCTTTTGATCTCTCTTACCTGCGCTGCATACCGGAAATGGTCATTATGACCCCGAGCGATG
AAAACGAATGTCGCCAGATGCTCTATACCGGCTATCACTATAACGATGGCCCGTCAGCGGTACGCTACCCGCGTGGCAAC
GCGGTTGGCGTGGAACTGACGCCGCTGGAAAAACTGCCAATTGGCAAAGGCATTGTGAAGCGTCGTGGCGAGAAACTGGC
GATCCTTAACTTTGGTACGCTGATGCCAGAAGCGGCGAAAGTCGCTGAATCGCTGAACGCTACGCTGGTCGATATGCGTT
TTGTGAAACCGCTTGATGAAGCGTTAATTCTGGAAATGGCCGCCAGCCATGAAGCGCTGGTCACCGTAGAAGAAAACGCC
ATTATGGGCGGCGCAGGCAGCGGAGTGAACGAAGTGCTGATGGCCCATCGTAAACCAGTACCCGTGCTGAACATTGGCCT
GCCTGACTTCTTTATTCCACAAGGAACGCAGGAAGAAATGCGCGCCGAACTCAGCCTCGATGCCGCCGGTATGGAAGCCA
AAATCAAGGCCTGGCTGGCATAA

Upstream 100 bases:

>100_bases
ACAACTGGCTGAACAGTCACTCGATACCTCGGCACTGGAAGCGCTAGCGGACTACATCATCCAGCGTAATAAATAAACAA
TAAGTATTAATAGGCCCCTG

Downstream 100 bases:

>100_bases
TCCCTACTCCACTCCTGCTATGCTTAAGAAATTATTCATGGCAGGAGTGGCAGCATGCAATACAACCCCTTAGGAAAAAC
CGACCTTCGCGTTTCCCGAC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPS
YSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELSLDAAGMEAKIKAWLA

Sequences:

>Translated_620_residues
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMA
FEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPS
YSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENA
IMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELSLDAAGMEAKIKAWLA
>Mature_619_residues
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQ
AYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAF
EAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGT
LFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSY
SKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYD
QVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNA
VGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAI
MGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELSLDAAGMEAKIKAWLA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=496, Percent_Identity=22.9838709677419, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4507521, Length=496, Percent_Identity=22.9838709677419, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=24.1448692152917, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI225637463, Length=495, Percent_Identity=23.8383838383838, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI225637461, Length=495, Percent_Identity=23.8383838383838, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI225637459, Length=495, Percent_Identity=23.8383838383838, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=99.5161290322581, Blast_Score=1273, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=531, Percent_Identity=24.2937853107345, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45550715, Length=531, Percent_Identity=24.2937853107345, Blast_Score=83, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24645119, Length=531, Percent_Identity=24.2937853107345, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24666278, Length=488, Percent_Identity=24.3852459016393, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67620; Mature: 67489

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCC
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
EEEEEECCHHHCCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCEEEHHHHHHHHHH
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELSLDAAGMEAKIKAWLA
HHHHCCCCCCCCHHHHEECC
>Mature Secondary Structure 
SFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSV
EEEEEHHCCCHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCEEEEE
GHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLND
CCCCCEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPG
CCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCEEEEE
VPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHCCCCCCHHHHHCC
DRYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDR
CHHHEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
AGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCC
AVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDE
EEEEEECCHHHCCCCCHHHHCCCCEEEEEECCCCCCHHHHHHHHCCCEEEHHHHHHHHHH
ALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEM
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHH
RAELSLDAAGMEAKIKAWLA
HHHHCCCCCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA