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The map label for this gene is apaH [H]

Identifier: 218703310

GI number: 218703310

Start: 54819

End: 55661

Strand: Reverse

Name: apaH [H]

Synonym: ECUMN_0051

Alternate gene names: 218703310

Gene position: 55661-54819 (Counterclockwise)

Preceding gene: 218703311

Following gene: 218703301

Centisome position: 1.07

GC content: 55.75

Gene sequence:

>843_bases
ATGGCGACATACCTTATTGGCGACGTTCATGGTTGTTACGATGAACTGATCGCATTGCTGCATAAAGTAGAATTTACCCC
TGGGAAAGATACCCTCTGGCTGACGGGCGATCTGGTCGCGCGCGGCCCGGGTTCGCTGGATGTTCTGCGCTATGTGAAAT
CCTTAGGCGACAGCGTACGTCTGGTGCTGGGCAATCACGATCTGCATCTGCTGGCGGTATTTGCCGGGATCAGCCGCAAT
AAACCGAAAGATCGCCTGACACCGCTGCTGGAAGCGCCGGATGCCGACGAGCTGCTTAACTGGCTGCGTCGCCAGCCTCT
GCTGCAAATCGACGAAGAGAAAAAGCTGGTGATGGCCCACGCCGGGATCACGCCACAGTGGGATCTGAAGACCGCCAAAG
AGTGCGCGCGCGATGTAGAAGCGGTGCTGTCGAGTGACTCCTATCCCTTCTTTCTTGATGCCATGTACGGCGATATGCCA
AATAACTGGTCACCGGAATTGCGGGGGCTGGGAAGACTGCGGTTTATCACCAACGCCTTTACCCGTATGCGTTTTTGCTT
CCCGAACGGTCAACTGGATATGTACAGCAAAGAATCGCCGGAAGAGGCCCCTGCCCCACTGAAACCGTGGTTTGCGATTC
CTGGCCCTGTCGCTGAAGAATACAGCATCGCCTTTGGTCACTGGGCATCGCTGGAAGGCAAAGGTACGCCGGAAGGTATT
TACGCGCTGGATACTGGCTGCTGCTGGGGTGGTACATTAACCTGCCTGCGCTGGGAAGATAAACACTATTTTGTCCAGCC
GTCGAACCGGCATAAGGATTTGGGCGAAGCGGCGGCGTCTTAA

Upstream 100 bases:

>100_bases
GCAGGGTCACTACGAAATGATCGATGAAAATGGCGTCCCTTTCAGCATCGACATTCCCGTATTCCGACTCGCCGTTCCCA
CACTCATTCATTAAAAGAAT

Downstream 100 bases:

>100_bases
ACACAGCCTGATACAGGAAGGCCGGATAAGACGCGACCGGCGTCGCATCCGGCACTAGCCGTAAATTCTATACAAACTTA
CCGCCGCTCCAGAATCTCAA

Product: diadenosine tetraphosphatase

Products: NA

Alternate protein names: Ap4A hydrolase; Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase; Diadenosine tetraphosphatase [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRN
KPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLKTAKECARDVEAVLSSDSYPFFLDAMYGDMP
NNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGI
YALDTGCCWGGTLTCLRWEDKHYFVQPSNRHKDLGEAAAS

Sequences:

>Translated_280_residues
MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRN
KPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLKTAKECARDVEAVLSSDSYPFFLDAMYGDMP
NNWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGI
YALDTGCCWGGTLTCLRWEDKHYFVQPSNRHKDLGEAAAS
>Mature_279_residues
ATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVRLVLGNHDLHLLAVFAGISRNK
PKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAHAGITPQWDLKTAKECARDVEAVLSSDSYPFFLDAMYGDMPN
NWSPELRGLGRLRFITNAFTRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGIY
ALDTGCCWGGTLTCLRWEDKHYFVQPSNRHKDLGEAAAS

Specific function: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP [H]

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Ap4A hydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1786234, Length=280, Percent_Identity=99.2857142857143, Blast_Score=576, Evalue=1e-166,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004617
- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.6.1.41 [H]

Molecular weight: Translated: 31306; Mature: 31175

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVR
CCEEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEECCCCHHHHHHHHHHCCCCEE
LVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAH
EEECCCCCEEHHEEHHCCCCCCHHHHCHHHCCCCHHHHHHHHHHCCCEEECCCCEEEEEE
AGITPQWDLKTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAF
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCHHHHHCHHHHHHHHHH
TRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGI
HHEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEECCCCCCCCCCE
YALDTGCCWGGTLTCLRWEDKHYFVQPSNRHKDLGEAAAS
EEEECCCCCCCEEEEEEEECCEEEECCCCCCCHHHHHHCC
>Mature Secondary Structure 
ATYLIGDVHGCYDELIALLHKVEFTPGKDTLWLTGDLVARGPGSLDVLRYVKSLGDSVR
CEEEEECHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEECCCCHHHHHHHHHHCCCCEE
LVLGNHDLHLLAVFAGISRNKPKDRLTPLLEAPDADELLNWLRRQPLLQIDEEKKLVMAH
EEECCCCCEEHHEEHHCCCCCCHHHHCHHHCCCCHHHHHHHHHHCCCEEECCCCEEEEEE
AGITPQWDLKTAKECARDVEAVLSSDSYPFFLDAMYGDMPNNWSPELRGLGRLRFITNAF
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCHHHHHCHHHHHHHHHH
TRMRFCFPNGQLDMYSKESPEEAPAPLKPWFAIPGPVAEEYSIAFGHWASLEGKGTPEGI
HHEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCEECCCCCCCCCCE
YALDTGCCWGGTLTCLRWEDKHYFVQPSNRHKDLGEAAAS
EEEECCCCCCCEEEEEEEECCEEEECCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA