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The map label for this gene is safA [H]

Identifier: 218700129

GI number: 218700129

Start: 1860918

End: 1861115

Strand: Reverse

Name: safA [H]

Synonym: ECIAI39_1765

Alternate gene names: 218700129

Gene position: 1861115-1860918 (Counterclockwise)

Preceding gene: 218700130

Following gene: 218700128

Centisome position: 36.26

GC content: 37.88

Gene sequence:

>198_bases
ATGCATGCGACCACAGTGAAAAACAAAATCACGCAAAGAGACAACTATAAAGAAATCATGTCTGTAATTGTGGTTGTCTT
ATTACTGACACTTACGTTGATAGCCATTTTTTCGGCAATTGATCAGCTGGGTATTTCAGAAATGGGGCGCATTGCAAGAG
ATCTTACACATTTCATTATCAATGGTTTGCAAGACTGA

Upstream 100 bases:

>100_bases
TACTGAAGCACCAGTCCTATTTCCTCTTTTATCCAGCCTGTTATATTAAGCATACTGATTAACGATTTTTAACGTTATCC
GCTAAATAAACATATTTGAA

Downstream 100 bases:

>100_bases
AAATAAACAGCAAATTATCAATATGAAATGTTAAAAAAGTATCGATAAAAACTTTATTGTTTTAAGGAGATAAAATGTCG
CTCGTTTGTTCTGTTATATT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 65; Mature: 65

Protein sequence:

>65_residues
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINGLQD

Sequences:

>Translated_65_residues
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINGLQD
>Mature_65_residues
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINGLQD

Specific function: Connects the signal transduction between the two- component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SafA family [H]

Homologues:

Organism=Escherichia coli, GI1787777, Length=64, Percent_Identity=95.3125, Blast_Score=95, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 7298; Mature: 7298

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFII
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
NGLQD
HHCCC
>Mature Secondary Structure
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFII
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
NGLQD
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12384590; 12704152 [H]