Click here to switch to the map view.

The map label for this gene is tetR [H]

Identifier: 218698047

GI number: 218698047

Start: 4973350

End: 4973976

Strand: Reverse

Name: tetR [H]

Synonym: EC55989_4857

Alternate gene names: 218698047

Gene position: 4973976-4973350 (Counterclockwise)

Preceding gene: 218698049

Following gene: 218698043

Centisome position: 96.49

GC content: 40.19

Gene sequence:

>627_bases
ATGATGTCTAGATTAGATAAAAGTAAAGTGATTAACAGCGCATTAGAGCTGCTTAATGAGGTCGGAATCGAAGGTTTAAC
AACCCGTAAACTCGCCCAGAAGCTAGGTGTAGAGCAGCCTACATTGTATTGGCATGTAAAAAATAAGCGGGCTTTGCTCG
ACGCCTTAGCCATTGAGATGTTAGATAGGCACCATACTCACTTTTGCCCTTTAGAAGGGGAAAGCTGGCAAGATTTTTTA
CGTAATAACGCTAAAAGTTTTAGATGTGCTTTACTAAGTCATCGCGATGGAGCAAAAGTACATTTAGGTACACGGCCTAC
AGAAAAACAGTATGAAACTCTCGAAAATCAATTAGCCTTTTTATGCCAACAAGGTTTTTCACTAGAGAATGCATTATATG
CACTCAGCGCTGTGGGGCATTTTACTTTAGGTTGCGTATTGGAAGATCAAGAGCATCAAGTCGCTAAAGAAGAAAGGGAA
ACACCTACTACTGATAGTATGCCGCCATTATTACGACAAGCTATCGAATTATTTGATCACCAAGGTGCAGAGCCAGCCTT
CTTATTCGGCCTTGAATTGATCATATGCGGATTAGAAAAACAACTTAAATGTGAAAGTGGGTCTTAA

Upstream 100 bases:

>100_bases
CGATCTTTGTCGAACTATTCATTTCACTTTTCTCTATCACTGATAGGGAGTGGTAAAATAACTCTATCAATGATAGAGTG
TCAACAAAAATTAGGAATTA

Downstream 100 bases:

>100_bases
AAGCAGCATAACCTTTTTCCGTGATGGTAACTTCACGGTAACCAAGATGTCGAGTTAACCACCCTTTAGATTCATAAAGC
GAAAATAATGCGGCTCCAAC

Product: tetracycline repressor protein TetR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFL
RNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERE
TPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS

Sequences:

>Translated_208_residues
MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFL
RNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERE
TPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS
>Mature_208_residues
MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEMLDRHHTHFCPLEGESWQDFL
RNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAFLCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERE
TPTTDSMPPLLRQAIELFDHQGAEPAFLFGLELIICGLEKQLKCESGS

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23486; Mature: 23486

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEM
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHH
LDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAF
HHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHH
LCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDH
HHHHCCCHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
QGAEPAFLFGLELIICGLEKQLKCESGS
CCCCHHHHHHHHHHHHCCHHHCCCCCCC
>Mature Secondary Structure
MMSRLDKSKVINSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIEM
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHH
LDRHHTHFCPLEGESWQDFLRNNAKSFRCALLSHRDGAKVHLGTRPTEKQYETLENQLAF
HHHCCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHH
LCQQGFSLENALYALSAVGHFTLGCVLEDQEHQVAKEERETPTTDSMPPLLRQAIELFDH
HHHHCCCHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHC
QGAEPAFLFGLELIICGLEKQLKCESGS
CCCCHHHHHHHHHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6330687; 3208760; 6311683; 3062183 [H]