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The map label for this gene is lyxK

Identifier: 218697297

GI number: 218697297

Start: 4117661

End: 4119157

Strand: Direct

Name: lyxK

Synonym: EC55989_4037

Alternate gene names: 218697297

Gene position: 4117661-4119157 (Clockwise)

Preceding gene: 218697296

Following gene: 218697298

Centisome position: 79.88

GC content: 56.98

Gene sequence:

>1497_bases
ATGACGCAATACTGGCTGGGGTTAGATTGTGGCGGTAGCTGGCTGAAAGCCGGGCTGTATGACCGCGAAGGCCGGGAGGC
AGGCGTGCAGCGCCTGCCGCTGTGCGCATTAAGCCCGCAGCCAGGTTGGGCAGAGCGCGATATGGCAGAACTGTGGCAAT
GCTGCATGGCTGTCATTCGCGAACTGCTTACCCATTCCGGCGTTAGCGGGGAACAAATTGTCGGTATCGGTATCTCCGCA
CAAGGAAAAGGCTTGTTTTTGCTGGATAAAAACAACAAGCCGCTCGGTAACGCCATTTTATCCTCGGATCGCCGGGCGAT
GGAAATCGTTCGTCGCTGGCAGGAAGATGGCATCCCGGAAAAACTCTACCCGCTGACCCGACAAACCTTGTGGACCGGGC
ATCCGGTATCGCTGTTACGTTGGCTTAAAGAGCACGAACCGGAACGCTACGCGCAAATTGGCTGCGTGATGATGACGCAC
GACTACCTGCGCTGGTGTTTAACCGGCGTCAAAGGCTGTGAAGAGAGTAATATTTCCGAGTCCAATCTCTACAACATGAG
TCTTGGGGAATATGACCCGTGCCTCACCGACTGGCTGGGGATTGCTGAAATCAATCACGCCCTGCCGCCTGTTGTCGGAT
CTGCCGAAATCTGCGGGGAGATCACCGCTCAGACAGCCGTACTGACCGGTCTGAAAGCGGGTACGCCCGTTGTCGGCGGC
CTGTTTGATGTGGTTTCCACCGCACTCTGCGCCGGGATCGAAGACGAATTTACCCTTAATGCGGTGATGGGCACCTGGGC
GGTGACCAGCGGCATAACCCGCGGTTTACGTGACGGTGAAGCGCATCCGTATGTCTATGGTCGCTACGTTAACGATGGTG
AATTTATCGTTCACGAAGCCAGCCCCACCTCTTCCGGCAACCTCGAATGGTTTACCGCACAGTGGGGAGAAATCTCGTTT
GATGAGATCAACCAGGCCGTTGCCAGCTTGCCGAAGGCCGGTGGCGATCTCTTTTTCCTGCCGTTCCTGTACGGCAGCAA
CGCCGGACTCGAGATGACCAGCGGTTTCTACGGGATGCAGGCCATTCACACCCGCGCACACCTGTTGCAGGCCATTTATG
AAGGGGTGGTGTTCAGCCATATGACCCATCTCAACCGGATGCGCGAACGTTTTACTGATGTGCACACCCTGCGCGTCACT
GGCGGCCCGGCGCATTCCGATGTCTGGATGCAAATGCTGGCGGACGTCAGCGGTCTGCGTATTGAGCTGCCGCAGGTGGA
AGAAACCGGCTGCTTTGGTGCAGCACTTGCCGCCCGCGTCGGCACCGGGGTTTATCGCGATTTCAGCGAAGCCCAGCGTG
ATTTACAGCACCCGGTGCGCACCCTGCTGCCGGATATGACCGCCCATCAGCTTTACCAACAAAAATACCAACGCTATCAG
CATCTCATTGCCGCACTTCAGGGCTTTCACGCCCGCATCAAGGAGCACATATTATGA

Upstream 100 bases:

>100_bases
CTTTAGCGACGCACTGGGTACTCAGGTCCGCGACATGTTTGTAAAAGATGTTCCGCAGGGTGCTGATCTACTGAAAGCCG
TGGATGAGGTGCAATAAACC

Downstream 100 bases:

>100_bases
GCCGACCACTTCTGCAACTGGCACTCGACCACTCATCACTTGAAGCCGCACAGCGCGACGTGACGCAGTTAAAAGACAGC
GTCGATATTGTCGAAGCGGG

Product: L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRELLTHSGVSGEQIVGIGISA
QGKGLFLLDKNNKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEASPTSSGNLEWFTAQWGEISF
DEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQ
HLIAALQGFHARIKEHIL

Sequences:

>Translated_498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRELLTHSGVSGEQIVGIGISA
QGKGLFLLDKNNKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEASPTSSGNLEWFTAQWGEISF
DEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQ
HLIAALQGFHARIKEHIL
>Mature_497_residues
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRELLTHSGVSGEQIVGIGISAQ
GKGLFLLDKNNKPLGNAILSSDRRAMEIVRRWQEDGIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHD
YLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGGL
FDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEASPTSSGNLEWFTAQWGEISFD
EINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTG
GPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQH
LIAALQGFHARIKEHIL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=494, Percent_Identity=25.3036437246964, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI164663828, Length=542, Percent_Identity=23.4317343173432, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=98.3935742971888, Blast_Score=1018, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=505, Percent_Identity=25.3465346534653, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1789987, Length=492, Percent_Identity=23.780487804878, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790361, Length=487, Percent_Identity=24.6406570841889, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24655555, Length=463, Percent_Identity=23.9740820734341, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655560, Length=463, Percent_Identity=23.9740820734341, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655570, Length=463, Percent_Identity=23.9740820734341, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655574, Length=463, Percent_Identity=23.9740820734341, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24655565, Length=463, Percent_Identity=23.9740820734341, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24656367, Length=520, Percent_Identity=23.2692307692308, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21357867, Length=532, Percent_Identity=22.3684210526316, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24656372, Length=167, Percent_Identity=28.1437125748503, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24657106, Length=543, Percent_Identity=23.0202578268877, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24657102, Length=543, Percent_Identity=23.0202578268877, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 55245; Mature: 55113

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
CCCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHH
ELLTHSGVSGEQIVGIGISAQGKGLFLLDKNNKPLGNAILSSDRRAMEIVRRWQEDGIPE
HHHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEC
SPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
HLIAALQGFHARIKEHIL
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
CCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHH
ELLTHSGVSGEQIVGIGISAQGKGLFLLDKNNKPLGNAILSSDRRAMEIVRRWQEDGIPE
HHHHHCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SNLYNMSLGEYDPCLTDWLGIAEINHALPPVVGSAEICGEITAQTAVLTGLKAGTPVVGG
CCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITRGLRDGEAHPYVYGRYVNDGEFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEEEEC
SPTSSGNLEWFTAQWGEISFDEINQAVASLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCEECCCHHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDLQHPVRTLLPDMTAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
HLIAALQGFHARIKEHIL
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]