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The map label for this gene is cusR

Identifier: 218697185

GI number: 218697185

Start: 3986794

End: 3987474

Strand: Direct

Name: cusR

Synonym: EC55989_3917

Alternate gene names: 218697185

Gene position: 3986794-3987474 (Clockwise)

Preceding gene: 218697178

Following gene: 218697186

Centisome position: 77.34

GC content: 51.4

Gene sequence:

>681_bases
ATGAAAATATTGATCGTCGAAGACGAAATTAAAACAGGTGAATATCTCAGCAAAGGGCTTACAGAGGCAGGGTTCGTAGT
GGATCACGCTGATAATGGTCTTACCGGATATCATCTCGCCATGACAGCCGAGTATGATTTAGTCATTCTGGATATCATGC
TACCTGATGTGAACGGCTGGGATATCATCCGCATGCTGCGCACTGCCGGAAAGGGTATGCCGGTCTTACTGCTGACAGCC
CTCGGCACGATCGAACATAGGGTCAAAGGACTGGAACTGGGTGCGGACGATTATCTGGTTAAACCCTTTGCGTTTGCCGA
ACTGCTCGCCCGGGTGAGAACCCTTCTGAGGCGGGGAAACACGATGATCACGGAAAGCCAGTTTAAGGTGGCTGACCTCT
CGATTGATCTCGTATCCAGAAAAGTCAGTCGCGCCGGAAACCGCATTGTGCTCACCAGTAAAGAGTTCAGCCTGCTGGAA
TTCTTCATTCGCCATCAGGGAGAGGTTCTTCCCCGCTCCCTGATTGCCTCTCAGGTCTGGGACATGAATTTTGACAGCGA
CACTAATGCGATCGATGTCGCAGTAAAGCGACTCCGCGCTAAAATAGACAACGATTACGAGACAAAGCTGATCCAGACAG
TCCGGGGCGTGGGCTACATGCTGGAGGTCCCGGATGCATAG

Upstream 100 bases:

>100_bases
CGGGTGACAGGATAATGACAATGTTGTCATTTTTGCTGTAATCCGTTGATAACGATCGTGGGCGCAATAGAATGACATTA
GCAGCCAGCCGGGGAGCAAG

Downstream 100 bases:

>100_bases
CAAACCTTCCAGACGCCCTTTCTCACTCGCTCTGCGGCTGACCTTTTTTATCAGCCTGTCCACGATACTGGCTTTTATCG
CATTCACCTGGTTTATGCTG

Product: DNA-binding transcriptional activator CusR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKILIVEDEIKTGEYLSKGLTEAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDVNGWDIIRMLRTAGKGMPVLLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNTMITESQFKVADLSIDLVSRKVSRAGNRIVLTSKEFSLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA

Sequences:

>Translated_226_residues
MKILIVEDEIKTGEYLSKGLTEAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDVNGWDIIRMLRTAGKGMPVLLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNTMITESQFKVADLSIDLVSRKVSRAGNRIVLTSKEFSLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA
>Mature_226_residues
MKILIVEDEIKTGEYLSKGLTEAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDVNGWDIIRMLRTAGKGMPVLLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNTMITESQFKVADLSIDLVSRKVSRAGNRIVLTSKEFSLLE
FFIRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA

Specific function: Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system silS/silR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=87.1681415929203, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=51.1415525114155, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.7239819004525, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35.4545454545455, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=36.6515837104072, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=35.7758620689655, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=33.1838565022422, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.2941176470588, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=35, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.9557522123894, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=31.858407079646, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=35.0877192982456, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=31.1688311688312, Blast_Score=94, Evalue=5e-21,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.0884955752212, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1790437, Length=132, Percent_Identity=29.5454545454545, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=31.304347826087, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25298; Mature: 25298

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILIVEDEIKTGEYLSKGLTEAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDVNGW
CEEEEEECCCCCHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCH
DIIRMLRTAGKGMPVLLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECCCCCEECHHHHHHHHHHHHHHHHCCC
TMITESQFKVADLSIDLVSRKVSRAGNRIVLTSKEFSLLEFFIRHQGEVLPRSLIASQVW
CEEECCCEEEEHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCC
>Mature Secondary Structure
MKILIVEDEIKTGEYLSKGLTEAGFVVDHADNGLTGYHLAMTAEYDLVILDIMLPDVNGW
CEEEEEECCCCCHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEEEECCCCCH
DIIRMLRTAGKGMPVLLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEECCCCCEECHHHHHHHHHHHHHHHHCCC
TMITESQFKVADLSIDLVSRKVSRAGNRIVLTSKEFSLLEFFIRHQGEVLPRSLIASQVW
CEEECCCEEEEHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHH
DMNFDSDTNAIDVAVKRLRAKIDNDYETKLIQTVRGVGYMLEVPDA
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]