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The map label for this gene is ybiC

Identifier: 218694275

GI number: 218694275

Start: 896584

End: 897669

Strand: Direct

Name: ybiC

Synonym: EC55989_0845

Alternate gene names: 218694275

Gene position: 896584-897669 (Clockwise)

Preceding gene: 218694274

Following gene: 218694281

Centisome position: 17.39

GC content: 55.43

Gene sequence:

>1086_bases
ATGGAAAGTGGTCATCGCTTTGATGCTCAGACGCTGCACAGTTTTATTCAGGCTGTATTTCGTCAGATGGGTAGCGAGGA
ACAAGAAGCGAAATTAGTGGCCGATCATTTAATCGCGGCAAACCTGGCAGGGCATGATTCTCATGGTATTGGCATGATCC
CAAGCTATGTGCGTTCCTGGAGTCAGGGGCATCTGCAAATTAACCATCATGCCAAAATCGTTAAAGAGGCGGGGGCGGCA
GTCACGCTCGATGGCGATCGCGCATTCGGTCAGGTCGCGGCACACGAAGCGATGGCGCTGGGGATTGAGAAAGCGCATCA
GCACGGTATTGCTGCCGTGGCGCTACATAACTCGCATCATATCGGCCGTATCGGTTACTGGGCGGAGCAGTGTGCAGCGG
CGGGGTTTGTCTCTATCCACTTTGTTAGCGTGGTCGGTATTCCAATGGTCGCACCGTTCCACGGTCGCGACAGCCGCTTT
GGCACCAATCCGTTCTGTGTGGTTTTCCCTCGTAAAGATAATTTCCCGCTGTTGCTTGATTACGCCACCAGCGCCATTGC
ATTTGGCAAAACCCGCGTCGCCTGGCATAAAGGCGTCCCCGTGCCGCCAGGTTGCCTGATTGACGTTAACGGCGTGCCGA
CGACCAATCCGGCGGTAATGCAGGAGTCGCCGTTGGGTTCGCTGTTGACCTTTGCCGAACATAAAGGCTACGCCCTTGCA
GCGATGTGTGAAATTCTTGGCGGGGCGCTTTCCGGCGGTAAAACGACGCATCAGGAAACGTTACAAACCAGTCCCGATGC
CATTCTTAACTGCATGACCACTATCATCATCAACCCGGAACTCTTCGGCGCGCCGGATTGTAGCGCGCAGACCGAAGCCT
TTGCCGAGTGGGTGAAAGCCTCGCCGCATGATGATGATAAGCCGATTTTGCTACCGGGCGAGTGGGAAGTGAACACGCAT
CGCGAACGGCAGGAGCAGGGGATTCCATTGGATGCGGGAAGCTGGCAGGCCATTTGTGATGCGGCGCGGCAGATTGGTAT
GTCGGAAGAGACGTTGCAGGCTTTCTGTCAGCAGTTAGCCAGCTAA

Upstream 100 bases:

>100_bases
CCCCACCGCAATATGAAATTCCTGCATCTTTATTGACCTTCCCGCGCCCGGCGTGCAGCATAAAAAAACAACAAACACAT
AACATAAACAGGAGTTAACC

Downstream 100 bases:

>100_bases
AAAAAAGCCCGTCCAGTGGCGGACGGGCAAACAAGGGTAACATAGGATCAATGAGGGTTAGAGCATATGCGTCTGTCGGC
AAACAGACAGGGAAATACTT

Product: hypothetical protein

Products: oxaloacetate; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCSAQTEAFAEWVKASPHDDDKPILLPGEWEVNTH
RERQEQGIPLDAGSWQAICDAARQIGMSEETLQAFCQQLAS

Sequences:

>Translated_361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCSAQTEAFAEWVKASPHDDDKPILLPGEWEVNTH
RERQEQGIPLDAGSWQAICDAARQIGMSEETLQAFCQQLAS
>Mature_361_residues
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAA
VTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRF
GTNPFCVVFPRKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCSAQTEAFAEWVKASPHDDDKPILLPGEWEVNTH
RERQEQGIPLDAGSWQAICDAARQIGMSEETLQAFCQQLAS

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=361, Percent_Identity=98.6149584487535, Blast_Score=737, Evalue=0.0,
Organism=Escherichia coli, GI1786727, Length=356, Percent_Identity=29.7752808988764, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1790000, Length=331, Percent_Identity=24.1691842900302, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17507179, Length=316, Percent_Identity=29.1139240506329, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17536633, Length=351, Percent_Identity=27.0655270655271, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45553211, Length=313, Percent_Identity=30.6709265175719, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24667912, Length=313, Percent_Identity=30.6709265175719, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24667908, Length=313, Percent_Identity=30.6709265175719, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24667904, Length=311, Percent_Identity=30.8681672025724, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24658010, Length=306, Percent_Identity=28.4313725490196, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24648360, Length=334, Percent_Identity=27.8443113772455, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: 1.1.1.37

Molecular weight: Translated: 38854; Mature: 38854

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSW
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
SQGHLQINHHAKIVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHH
CCCCEEECHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
IGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLD
CCHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
YATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
CHHHHHHCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHH
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCSAQTEAFAEWVKA
HHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHC
SPHDDDKPILLPGEWEVNTHRERQEQGIPLDAGSWQAICDAARQIGMSEETLQAFCQQLA
CCCCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
S
C
>Mature Secondary Structure
MESGHRFDAQTLHSFIQAVFRQMGSEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSW
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCC
SQGHLQINHHAKIVKEAGAAVTLDGDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHH
CCCCEEECHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCC
IGRIGYWAEQCAAAGFVSIHFVSVVGIPMVAPFHGRDSRFGTNPFCVVFPRKDNFPLLLD
CCHHHHHHHHHHHCCHHHHHHHHHHCCCEECCCCCCCCCCCCCCEEEEEECCCCCCEEEE
YATSAIAFGKTRVAWHKGVPVPPGCLIDVNGVPTTNPAVMQESPLGSLLTFAEHKGYALA
CHHHHHHCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCHHH
AMCEILGGALSGGKTTHQETLQTSPDAILNCMTTIIINPELFGAPDCSAQTEAFAEWVKA
HHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHC
SPHDDDKPILLPGEWEVNTHRERQEQGIPLDAGSWQAICDAARQIGMSEETLQAFCQQLA
CCCCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-malate; NAD+

Specific reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]