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The map label for this gene is hsdS [H]

Identifier: 218692731

GI number: 218692731

Start: 5143155

End: 5144909

Strand: Reverse

Name: hsdS [H]

Synonym: ECED1_5212

Alternate gene names: 218692731

Gene position: 5144909-5143155 (Counterclockwise)

Preceding gene: 218692732

Following gene: 218692730

Centisome position: 98.76

GC content: 41.42

Gene sequence:

>1755_bases
ATGAGTGTGGAAAAGCTGATCGTTGATCATATGGAAACCTGGACCTCGGCGTTGCAAACCCGTTCCACCGCCGGGCGCGG
CAGTTCCGGTAAAATTGATTTGTATGGCATTAAGAAATTGCGTGAGCTGATTCTGGAACTGGCGGTGCGCGGTAAACTGG
TGCCGCAGGATCCGAATGATGAACCGGCGTCGGAGCTGCTGAAGCGTATTGCGGCGGAAAAAGCAGAGCTGGTGAAGCAA
GGTAAAATTAAAAAGCAAAAACCCCTGCCGGAAATTAGCGAGGAAGAGAAGCCGTTTGAATTGCCGGAGGGATGGGAGTG
GGTAACTTTTTCACATTTAGGCTATTTTTTTGGTGGTAAAACTCCAAGTAAAATGAAAGATGAATATTGGGGAGGAACTA
TTCCATGGGTAACCCCAAAAGATATGAAAACGAATCTAATAGTCGATTCTGAAGATAAGGTGACTCCTTTAGCCCTTGAA
GATGGTTTAACCAAAGTATCTCCAGGCAGTATACTATTTGTCGCAAGAAGTGGAATTCTAAGAAGAATTTTCCCAGTTGC
TATAACATCTATTGAATGTACAGTTAATCAAGATATAAAAGTATTATCACCATTTTTTAGTGATATTTCATACTATATAC
TATTGATGATGAATGGTTTCGAAAGATATATAATTGAGAATTTAACAAAAACAGGAACTACTGTTGAAAGCCTGTTGTTT
GAAGATTTTATATCACACCCATTCATGATTCCACCATTCGCAGAGCAGAATAGGATCTTAAGTACTGTCAAAAAACTCAT
GTCTCTTTGCGACCAACTGGAACAGCAATCCCTGACCACTCTGGACGCACATCAGCAACTGGTTGAAACCCTGTTGGGAA
CGCTTACAGACAGTCAAAACGCCGAGGAACTGGCTGAAAACTGGGCGCGTATTAGCGAACATTTCGACACACTATTTACC
ACTGAAGCCAGCGTGGATGCGTTAAAACAGACCATTCTGCAACTGGCCGTAATGGGTAAACTTGTGCCGCAGGATCCGAA
TGACGAACCAGCCTCTGAACTGCTCAAACGAATTGCGCAGGAAAAAGCTCAACTGGTGAAAGAAGGGAAAATAAAAAAAC
AAAAACCGTTGCCCCCGATTAGCGATGAGGAAAAACCGTTTGAACTTCCGGAAGGGTGGGAGTGGTGTCGTTTAAATGAT
ATTTCATCTAAAATTACTGATGGAGATCATAAAACACCACCTCGTATTGCCGAAGGGTATAAATTACTTTCAGCAAAAAA
TATCCGTGACGGTTATTTAGACTACAATAACTGTGATTATATCTCAGCGATTGACTACGAAAAATCCCGTGAGCGATGCT
TACCTGAAAAAGGTGACTTATTAATTGTTTCGGTTGGTGGAACAATTGGTAGATCTTCTTTAATTAAGGACTGTTCTGAT
TTCGCACTCGTAAGGAGCGTAGCGATTATAAAACCATTATTAATCGAACCTGAGTATTTAAAACTTGCAATGGACTCGAA
GTTATTACAGTCAATGATTCACTCTCATAAACGAGGCGGAGCTCAACCATGCCTATATCTTGGAGAAATTAGTAAATTTC
TATTCCCTACCCCCCCATTGGCGGAACAAAGGAATATAGTTAATAAAGTTAGTATCCTTATGGAAAAATGTAGATTTTTA
TTTTTAGGACTTCAATCCGCCCAGCAAACCCAACTACACGTTGCAGACGCACTCACTGACGCGGCGATAAACTAA

Upstream 100 bases:

>100_bases
TGTTAGCGCAGTATGCAAAACAGCAGGCGGAGATCCAGACGCTGCGTAATCAACTGTGCGATATTCTTGGCGCTGCGCTG
TCTGGCAAGGAGGTTAACTA

Downstream 100 bases:

>100_bases
TTTTCTCGCCCTCAAAAAACCAATAAAGCGGCTCAATAGCCGCTTTATTCACATCACCAAAAATTATATTTTACGCTAAT
TTTCATCTTATTTTCATTAA

Product: Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI)

Products: NA

Alternate protein names: S.EcoAI; Type I restriction enzyme EcoAI specificity protein; S protein [H]

Number of amino acids: Translated: 584; Mature: 583

Protein sequence:

>584_residues
MSVEKLIVDHMETWTSALQTRSTAGRGSSGKIDLYGIKKLRELILELAVRGKLVPQDPNDEPASELLKRIAAEKAELVKQ
GKIKKQKPLPEISEEEKPFELPEGWEWVTFSHLGYFFGGKTPSKMKDEYWGGTIPWVTPKDMKTNLIVDSEDKVTPLALE
DGLTKVSPGSILFVARSGILRRIFPVAITSIECTVNQDIKVLSPFFSDISYYILLMMNGFERYIIENLTKTGTTVESLLF
EDFISHPFMIPPFAEQNRILSTVKKLMSLCDQLEQQSLTTLDAHQQLVETLLGTLTDSQNAEELAENWARISEHFDTLFT
TEASVDALKQTILQLAVMGKLVPQDPNDEPASELLKRIAQEKAQLVKEGKIKKQKPLPPISDEEKPFELPEGWEWCRLND
ISSKITDGDHKTPPRIAEGYKLLSAKNIRDGYLDYNNCDYISAIDYEKSRERCLPEKGDLLIVSVGGTIGRSSLIKDCSD
FALVRSVAIIKPLLIEPEYLKLAMDSKLLQSMIHSHKRGGAQPCLYLGEISKFLFPTPPLAEQRNIVNKVSILMEKCRFL
FLGLQSAQQTQLHVADALTDAAIN

Sequences:

>Translated_584_residues
MSVEKLIVDHMETWTSALQTRSTAGRGSSGKIDLYGIKKLRELILELAVRGKLVPQDPNDEPASELLKRIAAEKAELVKQ
GKIKKQKPLPEISEEEKPFELPEGWEWVTFSHLGYFFGGKTPSKMKDEYWGGTIPWVTPKDMKTNLIVDSEDKVTPLALE
DGLTKVSPGSILFVARSGILRRIFPVAITSIECTVNQDIKVLSPFFSDISYYILLMMNGFERYIIENLTKTGTTVESLLF
EDFISHPFMIPPFAEQNRILSTVKKLMSLCDQLEQQSLTTLDAHQQLVETLLGTLTDSQNAEELAENWARISEHFDTLFT
TEASVDALKQTILQLAVMGKLVPQDPNDEPASELLKRIAQEKAQLVKEGKIKKQKPLPPISDEEKPFELPEGWEWCRLND
ISSKITDGDHKTPPRIAEGYKLLSAKNIRDGYLDYNNCDYISAIDYEKSRERCLPEKGDLLIVSVGGTIGRSSLIKDCSD
FALVRSVAIIKPLLIEPEYLKLAMDSKLLQSMIHSHKRGGAQPCLYLGEISKFLFPTPPLAEQRNIVNKVSILMEKCRFL
FLGLQSAQQTQLHVADALTDAAIN
>Mature_583_residues
SVEKLIVDHMETWTSALQTRSTAGRGSSGKIDLYGIKKLRELILELAVRGKLVPQDPNDEPASELLKRIAAEKAELVKQG
KIKKQKPLPEISEEEKPFELPEGWEWVTFSHLGYFFGGKTPSKMKDEYWGGTIPWVTPKDMKTNLIVDSEDKVTPLALED
GLTKVSPGSILFVARSGILRRIFPVAITSIECTVNQDIKVLSPFFSDISYYILLMMNGFERYIIENLTKTGTTVESLLFE
DFISHPFMIPPFAEQNRILSTVKKLMSLCDQLEQQSLTTLDAHQQLVETLLGTLTDSQNAEELAENWARISEHFDTLFTT
EASVDALKQTILQLAVMGKLVPQDPNDEPASELLKRIAQEKAQLVKEGKIKKQKPLPPISDEEKPFELPEGWEWCRLNDI
SSKITDGDHKTPPRIAEGYKLLSAKNIRDGYLDYNNCDYISAIDYEKSRERCLPEKGDLLIVSVGGTIGRSSLIKDCSDF
ALVRSVAIIKPLLIEPEYLKLAMDSKLLQSMIHSHKRGGAQPCLYLGEISKFLFPTPPLAEQRNIVNKVSILMEKCRFLF
LGLQSAQQTQLHVADALTDAAIN

Specific function: The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. In the presence of the R subunit the complex can also act as an endonuclease, binding to

COG id: COG0732

COG function: function code V; Restriction endonuclease S subunits

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I restriction system S methylase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000055 [H]

Pfam domain/function: PF01420 Methylase_S [H]

EC number: NA

Molecular weight: Translated: 65623; Mature: 65492

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEKLIVDHMETWTSALQTRSTAGRGSSGKIDLYGIKKLRELILELAVRGKLVPQDPND
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCC
EPASELLKRIAAEKAELVKQGKIKKQKPLPEISEEEKPFELPEGWEWVTFSHLGYFFGGK
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCC
TPSKMKDEYWGGTIPWVTPKDMKTNLIVDSEDKVTPLALEDGLTKVSPGSILFVARSGIL
CCHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCEEHHCCCCCCCCCCEEEEEHHHHH
RRIFPVAITSIECTVNQDIKVLSPFFSDISYYILLMMNGFERYIIENLTKTGTTVESLLF
HHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EDFISHPFMIPPFAEQNRILSTVKKLMSLCDQLEQQSLTTLDAHQQLVETLLGTLTDSQN
HHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AEELAENWARISEHFDTLFTTEASVDALKQTILQLAVMGKLVPQDPNDEPASELLKRIAQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EKAQLVKEGKIKKQKPLPPISDEEKPFELPEGWEWCRLNDISSKITDGDHKTPPRIAEGY
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCCCCHHHHHH
KLLSAKNIRDGYLDYNNCDYISAIDYEKSRERCLPEKGDLLIVSVGGTIGRSSLIKDCSD
HHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHH
FALVRSVAIIKPLLIEPEYLKLAMDSKLLQSMIHSHKRGGAQPCLYLGEISKFLFPTPPL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
AEQRNIVNKVSILMEKCRFLFLGLQSAQQTQLHVADALTDAAIN
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVEKLIVDHMETWTSALQTRSTAGRGSSGKIDLYGIKKLRELILELAVRGKLVPQDPND
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCC
EPASELLKRIAAEKAELVKQGKIKKQKPLPEISEEEKPFELPEGWEWVTFSHLGYFFGGK
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHCCC
TPSKMKDEYWGGTIPWVTPKDMKTNLIVDSEDKVTPLALEDGLTKVSPGSILFVARSGIL
CCHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCEEHHCCCCCCCCCCEEEEEHHHHH
RRIFPVAITSIECTVNQDIKVLSPFFSDISYYILLMMNGFERYIIENLTKTGTTVESLLF
HHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EDFISHPFMIPPFAEQNRILSTVKKLMSLCDQLEQQSLTTLDAHQQLVETLLGTLTDSQN
HHHHCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AEELAENWARISEHFDTLFTTEASVDALKQTILQLAVMGKLVPQDPNDEPASELLKRIAQ
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
EKAQLVKEGKIKKQKPLPPISDEEKPFELPEGWEWCRLNDISSKITDGDHKTPPRIAEGY
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCCCCCCCHHHHHH
KLLSAKNIRDGYLDYNNCDYISAIDYEKSRERCLPEKGDLLIVSVGGTIGRSSLIKDCSD
HHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHH
FALVRSVAIIKPLLIEPEYLKLAMDSKLLQSMIHSHKRGGAQPCLYLGEISKFLFPTPPL
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
AEQRNIVNKVSILMEKCRFLFLGLQSAQQTQLHVADALTDAAIN
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2642743 [H]