BacMap

Definition	Escherichia coli ED1a chromosome, complete genome.
Accession	NC_011745
Length	5,209,548

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The map label for this gene is idnO [H]

Identifier: 218692652

GI number: 218692652

Start: 5061821

End: 5062585

Strand: Reverse

Name: idnO [H]

Synonym: ECED1_5120

Alternate gene names: 218692652

Gene position: 5062585-5061821 (Counterclockwise)

Preceding gene: 218692653

Following gene: 218692651

Centisome position: 97.18

GC content: 49.41

Gene sequence:

>765_bases
ATGAACGATCTATTTTCACTGGCAGGAAAAAATATCTTGATTACCGGTTCAGCACAGGGCATTGGCTTTTTACTGGCAAC
CGGCCTGGGTAAATATGGCGCACAAATAATTATTAATGATATTACTGCCGAACGCGCAGAACTTGCTGTAGAAAAACTCC
ACCAGGAGGGTATTCAGGCCGTTGCCGCACCTTTTAATGTTACTCATAAACATGAAATTGATGCCGCCGTTGAACATATC
GAAAAGGACATCGGCCCCATTGATGTGCTGGTGAATAACGCCGGTATCCAGCGCCGTCATCCTTTTACTGAGTTCCCTGA
ACAAGAGTGGAATGATGTGATCGCAGTAAACCAGACCGCCGTGTTCCTGGTGTCGCAAGCGGTAACTCGTCACATGGTTG
AACGCAAGGCAGGTAAAGTTATTAATATTTGCTCGATGCAAAGCGAACTGGGACGTGACACCATCACCCCTTATGCCGCA
TCGAAAGGGGCGGTAAAAATGCTCACCCGCGGCATGTGCGTCGAGCTGTCGCGCCACAATATTCAGGTCAACGGTATTGC
GCCGGGCTATTTCAAAACAGAAATGACTAAAGCACTGGTTGAGGACGAAGCCTTCACCGCCTGGTTGTGCAAACGGACCC
CCGCCGCACGCTGGGGAGATCCGCAGGAACTGATTGGTGCTGCGGTGTTCCTTTCTTCAAAAGCCTCTGATTTCGTAAAC
GGCCACCTGTTGTTTGTTGATGGCGGCATGTTAGTGGCTGTTTAA

Upstream 100 bases:

>100_bases
CCTTCACTGACCTGGAAGAGGCGCTACGTTTCGCCGGTGATAAAACCCAGGCAGCAAAAGTCCAGCTTGTTTTCTAAGAG
ATAAATAAAGGAATAATACA

Downstream 100 bases:

>100_bases
CAGCTACTACCCTACGTGCAGCACGAAAGCGCTGCTTTTCTGGCACTAATAAGAGATAAAGACTATGCCATTAATCATTA
TTGCGGCAGGCGTCGCGCTG

Product: gluconate 5-dehydrogenase

Products: NA

Alternate protein names: 5-keto-D-gluconate 5-reductase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFNVTHKHEIDAAVEHI
EKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAA
SKGAVKMLTRGMCVELSRHNIQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVN
GHLLFVDGGMLVAV

Sequences:

>Translated_254_residues
MNDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFNVTHKHEIDAAVEHI
EKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAA
SKGAVKMLTRGMCVELSRHNIQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVN
GHLLFVDGGMLVAV
>Mature_254_residues
MNDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQAVAAPFNVTHKHEIDAAVEHI
EKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTAVFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAA
SKGAVKMLTRGMCVELSRHNIQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVN
GHLLFVDGGMLVAV

Specific function: Catalyzes a reversible reduction of 5-ketoglutanate to form D-gluconate. Dependent on NADP, almost inactive with NAD [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=31.2, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI32483357, Length=247, Percent_Identity=29.9595141700405, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI40254992, Length=237, Percent_Identity=30.379746835443, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI15277342, Length=249, Percent_Identity=29.718875502008, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI19923817, Length=250, Percent_Identity=28, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI126723750, Length=247, Percent_Identity=27.5303643724696, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=28.3400809716599, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI59889578, Length=227, Percent_Identity=31.7180616740088, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI10190704, Length=245, Percent_Identity=27.3469387755102, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI4504505, Length=233, Percent_Identity=27.0386266094421, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=29.3172690763052, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI33667109, Length=198, Percent_Identity=29.2929292929293, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI210032110, Length=195, Percent_Identity=26.1538461538462, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4758504, Length=258, Percent_Identity=28.2945736434109, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI126723191, Length=182, Percent_Identity=29.1208791208791, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI7706318, Length=190, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4503817, Length=207, Percent_Identity=23.1884057971014, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI209862901, Length=199, Percent_Identity=28.643216080402, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI19923983, Length=199, Percent_Identity=28.643216080402, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI226371731, Length=211, Percent_Identity=28.436018957346, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4503301, Length=226, Percent_Identity=23.8938053097345, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI40807363, Length=194, Percent_Identity=26.2886597938144, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI20149619, Length=191, Percent_Identity=26.7015706806283, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI40254986, Length=194, Percent_Identity=29.3814432989691, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI83715985, Length=259, Percent_Identity=27.4131274131274, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=99.6062992125984, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI87082160, Length=250, Percent_Identity=40.8, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1789208, Length=248, Percent_Identity=41.5322580645161, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=35.1239669421488, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=35.8870967741936, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=34, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=32.5102880658436, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367175, Length=243, Percent_Identity=28.8065843621399, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786812, Length=253, Percent_Identity=25.296442687747, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1789378, Length=246, Percent_Identity=26.4227642276423, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789057, Length=253, Percent_Identity=22.1343873517787, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=26.9387755102041, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787526, Length=188, Percent_Identity=27.1276595744681, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787820, Length=179, Percent_Identity=26.2569832402235, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=32.2448979591837, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=30.6122448979592, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=32.5396825396825, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=26.530612244898, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17561402, Length=247, Percent_Identity=28.3400809716599, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI193203117, Length=194, Percent_Identity=27.319587628866, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI193203115, Length=189, Percent_Identity=28.042328042328, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71994600, Length=245, Percent_Identity=28.9795918367347, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=263, Percent_Identity=30.7984790874525, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17560150, Length=257, Percent_Identity=27.6264591439689, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=28.5171102661597, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=28.5714285714286, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=28.735632183908, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17563726, Length=259, Percent_Identity=27.7992277992278, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17564282, Length=193, Percent_Identity=27.4611398963731, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=259, Percent_Identity=28.1853281853282, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=257, Percent_Identity=26.0700389105058, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=259, Percent_Identity=25.4826254826255, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=264, Percent_Identity=29.9242424242424, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17568967, Length=189, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=264, Percent_Identity=26.5151515151515, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=25.4980079681275, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=264, Percent_Identity=24.6212121212121, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=254, Percent_Identity=26.7716535433071, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=261, Percent_Identity=25.6704980842912, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=24.5353159851301, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=26.0536398467433, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17551412, Length=254, Percent_Identity=25.9842519685039, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=27.7566539923954, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=23.9043824701195, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=25.6704980842912, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508895, Length=195, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17561272, Length=237, Percent_Identity=25.7383966244726, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997099, Length=223, Percent_Identity=28.2511210762332, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=255, Percent_Identity=25.0980392156863, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17555612, Length=217, Percent_Identity=26.7281105990783, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193210355, Length=196, Percent_Identity=26.0204081632653, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI115534660, Length=198, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71982365, Length=191, Percent_Identity=28.7958115183246, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=193, Percent_Identity=30.5699481865285, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323882, Length=198, Percent_Identity=30.8080808080808, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=253, Percent_Identity=26.4822134387352, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320089, Length=199, Percent_Identity=29.1457286432161, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=33.1983805668016, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24643142, Length=249, Percent_Identity=31.3253012048193, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=30.5220883534137, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=25.8064516129032, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24640492, Length=193, Percent_Identity=30.0518134715026, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=28.8, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=30.2325581395349, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281364892, Length=196, Percent_Identity=31.1224489795918, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357041, Length=249, Percent_Identity=28.5140562248996, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17737361, Length=251, Percent_Identity=27.8884462151394, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI18859837, Length=227, Percent_Identity=27.3127753303965, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644337, Length=250, Percent_Identity=29.6, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24581726, Length=196, Percent_Identity=27.5510204081633, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24584744, Length=195, Percent_Identity=27.6923076923077, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574402, Length=195, Percent_Identity=27.6923076923077, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358495, Length=198, Percent_Identity=25.2525252525253, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=27.5132275132275, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649181, Length=193, Percent_Identity=27.4611398963731, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357673, Length=234, Percent_Identity=24.3589743589744, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.69 [H]

Molecular weight: Translated: 27579; Mature: 27579

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQA
CCCCHHHCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
VAAPFNVTHKHEIDAAVEHIEKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTA
HHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHCCCEEEECHHH
VFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELSRHN
HHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHCCCEEEEECCE
IQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVN
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHC
GHLLFVDGGMLVAV
CEEEEEECCEEEEC
>Mature Secondary Structure
MNDLFSLAGKNILITGSAQGIGFLLATGLGKYGAQIIINDITAERAELAVEKLHQEGIQA
CCCCHHHCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
VAAPFNVTHKHEIDAAVEHIEKDIGPIDVLVNNAGIQRRHPFTEFPEQEWNDVIAVNQTA
HHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHCCCEEEECHHH
VFLVSQAVTRHMVERKAGKVINICSMQSELGRDTITPYAASKGAVKMLTRGMCVELSRHN
HHHHHHHHHHHHHHHHCCCEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHCCCEEEEECCE
IQVNGIAPGYFKTEMTKALVEDEAFTAWLCKRTPAARWGDPQELIGAAVFLSSKASDFVN
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHC
GHLLFVDGGMLVAV
CEEEEEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]