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The map label for this gene is lctP [H]

Identifier: 218692556

GI number: 218692556

Start: 4960659

End: 4962215

Strand: Reverse

Name: lctP [H]

Synonym: ECED1_5018

Alternate gene names: 218692556

Gene position: 4962215-4960659 (Counterclockwise)

Preceding gene: 218692561

Following gene: 218692555

Centisome position: 95.25

GC content: 46.44

Gene sequence:

>1557_bases
ATGCACGATTACCTGCTTTTTTTACTGGGACTTACACCGCTTCTGGCGATGATCATTTTGATTCTGAAAGTCAAAATGCC
CATACATTATGCCGTGCTTAGCACTCTCCTGATCACGCTAATCCTTGGGGGTGTTTTCTGGCAGACGCCAGTTATGGATA
TGGGATCTGCTGTGGTATACGGCACAATCAAAGGTTTGTGGCCAATTGTGATTGTTATCCTCGCTGCCATTTACAGCTAT
AACCTGATGAATGCGACAAAAAGCATGGATATTCTGAGAAATGTTCTGGCGAGCGTTAGTGATGACAAGCGTATCCAGGT
ACTTCTTATCTCATGGTGTTTTGGCGGATTTCTTGAGGCGGCAGCCGGTTACGGTACAGCTGTAGCAATCCCCATTGGTA
TACTGATTGCACTGGGCTTTAACCCACTAAAAGCAGCAATTGCGTCACTGGTTGCTAATACAGTCCCTACAGCATTTGGA
GCAGTCGGTATACCTGTCTCTGTACTTGCTGAACAAGTTAATTTGCCTGTAACCACACTCAGTGGGACGATTATTCTTCA
GCTGGCACTGTTCAACATTCTGCTCCCCTTCGTCATCGTCGCGATTATCGGTGGAGGGATGAAGGCTATACGAGGCGTAG
GATTAATTACCCTGATGTGCGGTGTCAGCACATTGATACCTCAGTATCTGGTGGCTGTTAATCTTGGTGCAGAACTCCCG
GCTTTCGCGGGAAGTCTTGTCAGTCTGATCGTTATAGTCTTTATGGCAAAAAACCGTAAAGAAAAAACAGAACCTGAATT
TCTTATTGATACTTCAGCAGATAGCGCCAGCGCACTTTCATACTCTCGTGGGGCGTTGTTACGTGCGTGCTCAATCTACA
TCCTGATTTTTCTGTTCATTCTGCTTTGCTCTCCACTGTTCCCGACGATAAAAAGTGCGGTGTCTCAGATTGCCTCGTCA
CTCAGTTTCTCTCTGAGTAACGGCAGCAATCTGTCGATGAAGATTGAATGGATCGCAACCCCCGGTGTTCTGATTATCAT
TGCCAGTGTTATTGGCGGCTTGATACAAAAAGCATCCCTGTCATGTCTGTTAAACGTATTTATCAGTACGGTAAAACAGC
TCAAAAACTCCATTATTGCCATTTCTGCGATTGTTGCCATGGCAACGGTAATGGATGTTTGTGGGTTAATTGGCACTCTG
GCACAAAGCCTTGTGGATCTCACTGGTGGAGCCTACCTCTTCATTGCTCCGGTTATCGGCGCTCTTGGTACATTTGTTAC
AGGCAGTGACACAAACTCCAACATTCTGTTCGGTAAATTGCAGACCACTGCGGCTGAAAAATTGCATGTGGACCCGCTCT
GGCTGGCTGCCGCAAATACATCTGGCGCAACAGGCGGCAAAATGATTTCTCCTCAGAGTATTGCTATCGCTGTTTCAGCC
ACCCGTATGGATGGTCAGGGCAGCGTAATCATGTCAGGAACACTGAAGTACTGCTTTGCTTATATTGTTATTCTTGGACT
GAAAGTAGGCCTTGTCTACCACCTGTTCATGGCCTGA

Upstream 100 bases:

>100_bases
ATTCTCCCCCTGATAACTAAACGCTCTCGTCCGACAGGGTGTGGAGACTATCAATATCCACAGTAATGATGCTGACTTTG
TTTTCGTTTGAGGAAATGAC

Downstream 100 bases:

>100_bases
GAAAAAACAACAAAAGGACGTGGAATATTAATCAACAGGAGAAATTTCTGTGAATGTTAACTTTTTCGTCACCTGCATTG
GTGATGCGTTTAAATCCCGG

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MHDYLLFLLGLTPLLAMIILILKVKMPIHYAVLSTLLITLILGGVFWQTPVMDMGSAVVYGTIKGLWPIVIVILAAIYSY
NLMNATKSMDILRNVLASVSDDKRIQVLLISWCFGGFLEAAAGYGTAVAIPIGILIALGFNPLKAAIASLVANTVPTAFG
AVGIPVSVLAEQVNLPVTTLSGTIILQLALFNILLPFVIVAIIGGGMKAIRGVGLITLMCGVSTLIPQYLVAVNLGAELP
AFAGSLVSLIVIVFMAKNRKEKTEPEFLIDTSADSASALSYSRGALLRACSIYILIFLFILLCSPLFPTIKSAVSQIASS
LSFSLSNGSNLSMKIEWIATPGVLIIIASVIGGLIQKASLSCLLNVFISTVKQLKNSIIAISAIVAMATVMDVCGLIGTL
AQSLVDLTGGAYLFIAPVIGALGTFVTGSDTNSNILFGKLQTTAAEKLHVDPLWLAAANTSGATGGKMISPQSIAIAVSA
TRMDGQGSVIMSGTLKYCFAYIVILGLKVGLVYHLFMA

Sequences:

>Translated_518_residues
MHDYLLFLLGLTPLLAMIILILKVKMPIHYAVLSTLLITLILGGVFWQTPVMDMGSAVVYGTIKGLWPIVIVILAAIYSY
NLMNATKSMDILRNVLASVSDDKRIQVLLISWCFGGFLEAAAGYGTAVAIPIGILIALGFNPLKAAIASLVANTVPTAFG
AVGIPVSVLAEQVNLPVTTLSGTIILQLALFNILLPFVIVAIIGGGMKAIRGVGLITLMCGVSTLIPQYLVAVNLGAELP
AFAGSLVSLIVIVFMAKNRKEKTEPEFLIDTSADSASALSYSRGALLRACSIYILIFLFILLCSPLFPTIKSAVSQIASS
LSFSLSNGSNLSMKIEWIATPGVLIIIASVIGGLIQKASLSCLLNVFISTVKQLKNSIIAISAIVAMATVMDVCGLIGTL
AQSLVDLTGGAYLFIAPVIGALGTFVTGSDTNSNILFGKLQTTAAEKLHVDPLWLAAANTSGATGGKMISPQSIAIAVSA
TRMDGQGSVIMSGTLKYCFAYIVILGLKVGLVYHLFMA
>Mature_518_residues
MHDYLLFLLGLTPLLAMIILILKVKMPIHYAVLSTLLITLILGGVFWQTPVMDMGSAVVYGTIKGLWPIVIVILAAIYSY
NLMNATKSMDILRNVLASVSDDKRIQVLLISWCFGGFLEAAAGYGTAVAIPIGILIALGFNPLKAAIASLVANTVPTAFG
AVGIPVSVLAEQVNLPVTTLSGTIILQLALFNILLPFVIVAIIGGGMKAIRGVGLITLMCGVSTLIPQYLVAVNLGAELP
AFAGSLVSLIVIVFMAKNRKEKTEPEFLIDTSADSASALSYSRGALLRACSIYILIFLFILLCSPLFPTIKSAVSQIASS
LSFSLSNGSNLSMKIEWIATPGVLIIIASVIGGLIQKASLSCLLNVFISTVKQLKNSIIAISAIVAMATVMDVCGLIGTL
AQSLVDLTGGAYLFIAPVIGALGTFVTGSDTNSNILFGKLQTTAAEKLHVDPLWLAAANTSGATGGKMISPQSIAIAVSA
TRMDGQGSVIMSGTLKYCFAYIVILGLKVGLVYHLFMA

Specific function: Plays a role in L-lactate utilization [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=518, Percent_Identity=34.5559845559846, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1789347, Length=540, Percent_Identity=32.5925925925926, Blast_Score=233, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 54320; Mature: 54320

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDYLLFLLGLTPLLAMIILILKVKMPIHYAVLSTLLITLILGGVFWQTPVMDMGSAVVY
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEH
GTIKGLWPIVIVILAAIYSYNLMNATKSMDILRNVLASVSDDKRIQVLLISWCFGGFLEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHH
AAGYGTAVAIPIGILIALGFNPLKAAIASLVANTVPTAFGAVGIPVSVLAEQVNLPVTTL
HCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEH
SGTIILQLALFNILLPFVIVAIIGGGMKAIRGVGLITLMCGVSTLIPQYLVAVNLGAELP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AFAGSLVSLIVIVFMAKNRKEKTEPEFLIDTSADSASALSYSRGALLRACSIYILIFLFI
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLCSPLFPTIKSAVSQIASSLSFSLSNGSNLSMKIEWIATPGVLIIIASVIGGLIQKASL
HHHCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHH
SCLLNVFISTVKQLKNSIIAISAIVAMATVMDVCGLIGTLAQSLVDLTGGAYLFIAPVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ALGTFVTGSDTNSNILFGKLQTTAAEKLHVDPLWLAAANTSGATGGKMISPQSIAIAVSA
HHHCCCCCCCCCCCEEEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEE
TRMDGQGSVIMSGTLKYCFAYIVILGLKVGLVYHLFMA
EEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MHDYLLFLLGLTPLLAMIILILKVKMPIHYAVLSTLLITLILGGVFWQTPVMDMGSAVVY
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEEEH
GTIKGLWPIVIVILAAIYSYNLMNATKSMDILRNVLASVSDDKRIQVLLISWCFGGFLEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHH
AAGYGTAVAIPIGILIALGFNPLKAAIASLVANTVPTAFGAVGIPVSVLAEQVNLPVTTL
HCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEH
SGTIILQLALFNILLPFVIVAIIGGGMKAIRGVGLITLMCGVSTLIPQYLVAVNLGAELP
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
AFAGSLVSLIVIVFMAKNRKEKTEPEFLIDTSADSASALSYSRGALLRACSIYILIFLFI
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LLCSPLFPTIKSAVSQIASSLSFSLSNGSNLSMKIEWIATPGVLIIIASVIGGLIQKASL
HHHCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHH
SCLLNVFISTVKQLKNSIIAISAIVAMATVMDVCGLIGTLAQSLVDLTGGAYLFIAPVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
ALGTFVTGSDTNSNILFGKLQTTAAEKLHVDPLWLAAANTSGATGGKMISPQSIAIAVSA
HHHCCCCCCCCCCCEEEEEHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEEEEE
TRMDGQGSVIMSGTLKYCFAYIVILGLKVGLVYHLFMA
EEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10508058 [H]