Click here to switch to the map view.

The map label for this gene is ptrB [H]

Identifier: 218689783

GI number: 218689783

Start: 1995977

End: 1998037

Strand: Reverse

Name: ptrB [H]

Synonym: ECED1_2050

Alternate gene names: 218689783

Gene position: 1998037-1995977 (Counterclockwise)

Preceding gene: 218689784

Following gene: 218689779

Centisome position: 38.35

GC content: 50.02

Gene sequence:

>2061_bases
ATGCTACCAAAAGCCGCCCGCATTCCCCACGCCATGACGCTTCATGGCGATACGCGCATCGATAATTACTACTGGCTGCG
GGACGATACGCGTTCTCAGCCGGAAGTCCTGGACTATCTGCAACAAGAAAATAGTTACGGTCATCGGGTGATGGCCTCGC
AACAAGCCTTGCAGGATCGCATCTTAAAGGAAATCATCGACCGCATTCCGCAACGAGAAGTTTCTGCGCCCTACATCAAA
AATGGCTACCGCTATCGGCATATTTATGAACCAGGCTGTGAATATGCTATCTACCAGCGTCAATCGGCGTTCAGTGAAGA
GTGGGACGAGTGGGAAACATTGCTCGATGCCAACAAGCGCGCGGCTCATAGTGAGTTTTATTCGATGGGCGGAATGGCGA
TTACGCCAGATAACACCATTATGGCACTGGCAGAAGATTTTCTTTCCCGACGGCAGTACGGCATTCGTTTTCGTAATCTG
GAAACAGGTAACTGGTACCCGGAACTGCTGGATAACGTTGAACCCAGCTTTGTCTGGGCAAATGACTCCTGGACTTTCTA
CTATGTTCGCAAGCATCCAGTGACGCTGCTGCCTTATCAGGTCTGGCGTCACGCCATCGGTACGCCAGCATCGCAAGATA
AACTGATTTACGAAGAAAAAGACGATACCTATTACGTCAGCCTGCATAAAACGACCTCGAAGCATTATGTGGTCATTCAT
CTGGCCAGCGCCACCACCAGTGAAGTTCGCCTGCTGGACGCGGAAATGGCCGATGCCGAGCCGTTTGTTTTTCTGCCTCG
CCGCAAAGATCACGAATACAGCCTTGATCACTACCAGCATCGGTTTTATCTGCGTTCCAACCGCCACGGTAAAAACTTTG
GCTTATACCGTACCCGTATGCGTGATGAGCAACAGTGGGAAGAGTTAATTCCGCCACGTGATAACATTATGCTGGAAGGG
TTTACGCTGTTTACCGACTGGCTGGTGGTTGAAGAGCGTCAGCGCGGGTTAACCAGTTTGCGGCAAATTAACCGCAAGAC
CCGGGAAGTCATTGGCATTGCCTTTGATGATCCGGCCTATGTGACCTGGATTGCCTACAATCCAGAACCTGAAACCGCGC
GATTGCGTTATGGTTATTCGTCCATGACCACACCAGATACTTTGTTTGAACTGGATATGGATACCGGTGAGCGTCGTGTA
TTAAAACAAACGGAGGTTCCTGGTTTTGATGCGGCGAATTACCGCAGTGAACACCTGTGGATAGTCGCCCGTGATGGCGT
CGAAGTTCCGGTTTCGCTGGTCTATCATCGCAAACATTTTCGCAAAGGACACAACCCGCTGCTGGTGTATGGCTACGGTT
CTTACGGCGCAAGTATTGATGCCGATTTCAGTTTTAGCCGCTTGAGTTTGTTGGATCGTGGATTTGTCTACGCCATTGTC
CATGTTCGTGGCGGCGGTGAGCTGGGGCAACAATGGTACGAGGACGGTAAATTTCTGAAGAAGAAAAATACGTTTAATGA
TTATCTTGATGCCTGCGATGCATTGTTAAAACTGGGCTATGGCTCTCCTTCGCTCTGTTATGCGATGGGCGGGAGTGCGG
GGGGTATGTTGATGGGCGTTGCGATTAATCAACGCCCGGAATTGTTCCACGGCGTTATCGCCCAGGTACTGTTTGTTGAT
GTTGTAACAACAATGCTGGATGAATCAATTCCTCTTACCACCGGCGAATTTGAAGAGTGGGGGAATCCGCAGGATCCGCA
ATATTACGAGTATATGAAAAGCTACAGCCCGTATGACAACGTCACCGCACAGGCTTATCCGCATTTACTGGTAACGACCG
GTTTACACGATTCTCAGGTGCAATATTGGGAACCGGCAAAATGGGTCGCTAAATTGCGCGAGCTGAAAACCGATGACCAT
CTTTTATTGCTCTGTACCGACATGGACTCAGGTCATGGCGGTAAATCTGGTCGCTTTAAATCGTACGAAGGCGTAGCGAT
GGAATATGCTTTTCTGGTCGCGCTGGCGCAGGGAACATTACCCGCTCAGTCAGCGGATTAA

Upstream 100 bases:

>100_bases
ATTACCTGTCATCATCTAAGCAATGACTACCCTGTTTCGCTTGCATCCCCGGTGAGTTTTGCCACCCTTATAAGATGTTT
CAACCAGAAAGAACAATAAC

Downstream 100 bases:

>100_bases
GTATTTTCCAGATAATGTTTCAGTGTTAAACGCAGCTCCGGGCTCATGCTGTCGAGGTTATTAAACAACCAGCGCAGATA
GCCCGGATCGCGTTCGGCAA

Product: protease 2

Products: NA

Alternate protein names: Oligopeptidase B; Protease II [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIK
NGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNL
ETGNWYPELLDNVEPSFVWANDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRMRDEQQWEELIPPRDNIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRV
LKQTEVPGFDAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFHGVIAQVLFVD
VVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDH
LLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQGTLPAQSAD

Sequences:

>Translated_686_residues
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIK
NGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNL
ETGNWYPELLDNVEPSFVWANDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRMRDEQQWEELIPPRDNIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRV
LKQTEVPGFDAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFHGVIAQVLFVD
VVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDH
LLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQGTLPAQSAD
>Mature_686_residues
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIK
NGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNL
ETGNWYPELLDNVEPSFVWANDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRMRDEQQWEELIPPRDNIMLEG
FTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRV
LKQTEVPGFDAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFHGVIAQVLFVD
VVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDNVTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDH
LLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQGTLPAQSAD

Specific function: Cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues [H]

COG id: COG1770

COG function: function code E; Protease II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=696, Percent_Identity=24.8563218390805, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI284172420, Length=474, Percent_Identity=29.746835443038, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI284172413, Length=474, Percent_Identity=29.746835443038, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI70778815, Length=474, Percent_Identity=29.746835443038, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI284172438, Length=474, Percent_Identity=29.746835443038, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI284172431, Length=474, Percent_Identity=29.746835443038, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI108860686, Length=214, Percent_Identity=40.1869158878505, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI108860692, Length=213, Percent_Identity=40.3755868544601, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1788150, Length=686, Percent_Identity=99.1253644314869, Blast_Score=1416, Evalue=0.0,
Organism=Drosophila melanogaster, GI24583414, Length=701, Percent_Identity=23.2524964336662, Blast_Score=165, Evalue=9e-41,
Organism=Drosophila melanogaster, GI221510989, Length=666, Percent_Identity=25.6756756756757, Blast_Score=153, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.83 [H]

Molecular weight: Translated: 79450; Mature: 79450

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDR
CCCCCCCCCEEEEECCCCEECCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
ILKEIIDRIPQREVSAPYIKNGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKR
HHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCHH
AAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNLETGNWYPELLDNVEPSFVWA
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHCCCCCCEEEE
NDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
CCCEEEEEEECCCCEEECHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCCEEEEE
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRM
EECCCCCCEEEEEHHCCCCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCCCCHHHHC
RDEQQWEELIPPRDNIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAY
CCHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCE
VTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRVLKQTEVPGFDAANYRSEHLW
EEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEE
IVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
EEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEEE
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGV
EEECCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEE
AINQRPELFHGVIAQVLFVDVVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDN
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHCCCCCCC
VTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDHLLLLCTDMDSGHGGKSGRFK
CCHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
SYEGVAMEYAFLVALAQGTLPAQSAD
CCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLPKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDR
CCCCCCCCCEEEEECCCCEECCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
ILKEIIDRIPQREVSAPYIKNGYRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKR
HHHHHHHHCCCCCCCCCHHHCCEEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHCCHH
AAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNLETGNWYPELLDNVEPSFVWA
HHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHCCCCCCEEEE
NDSWTFYYVRKHPVTLLPYQVWRHAIGTPASQDKLIYEEKDDTYYVSLHKTTSKHYVVIH
CCCEEEEEEECCCCEEECHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCCEEEEE
LASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRM
EECCCCCCEEEEEHHCCCCCCEEEECCCCCCCCCHHHHHEEEEEECCCCCCCCCCHHHHC
RDEQQWEELIPPRDNIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAY
CCHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCE
VTWIAYNPEPETARLRYGYSSMTTPDTLFELDMDTGERRVLKQTEVPGFDAANYRSEHLW
EEEEEECCCCCCEEEEECCCCCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEE
IVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSLLDRGFVYAIV
EEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCEEEEEE
HVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGV
EEECCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEE
AINQRPELFHGVIAQVLFVDVVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDN
EECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCHHHHHHHCCCCCCC
VTAQAYPHLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDHLLLLCTDMDSGHGGKSGRFK
CCHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCC
SYEGVAMEYAFLVALAQGTLPAQSAD
CCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1769955; 9097040; 9278503 [H]