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The map label for this gene is metH [H]

Identifier: 218551296

GI number: 218551296

Start: 4175546

End: 4179229

Strand: Direct

Name: metH [H]

Synonym: EFER_4072

Alternate gene names: 218551296

Gene position: 4175546-4179229 (Clockwise)

Preceding gene: 218551294

Following gene: 218551297

Centisome position: 91.0

GC content: 55.18

Gene sequence:

>3684_bases
GTGAGCAGCAAAGTGGAACAACTGCGTGCGCAGTTAAATGAACGTATTCTGGTGCTGGATGGCGGTATGGGCACTATGAT
CCAGAGCTATCGACTGAACGAAGCCGATTTTCGTGGTGAACGCTTTGCCGACTGGCCATGCGATCTCAAAGGCAACAACG
ACCTACTGGTGCTCAGCAAACCGGAAGTGATCGCCGCTATCCACAACGCCTACTTTGAAGCGGGTGCGGATATCATCGAA
ACCAACACCTTCAACTCCACGACTATTGCGATGGCGGATTACCAGATGGAATCCCTGTCGGCGGAAATCAACTTTGCGGC
GGCGAAGCTGGCGCGTGCCTGTGCTGACGAGTGGACCGCCCGTACGCCAGAGAAACCGCGCTACGTTGCCGGTGTTCTCG
GCCCGACCAACCGCACGGCGTCTATTTCTCCGGACGTGAACGATCCAGCATTCCGCAACATCACTTTTGACCAGCTGGTG
GCGGCTTATCGAGAATCCACTAAAGCGCTGGTGGAAGGCGGTGCGGATCTGATCCTGATTGAAACCGTTTTCGACACCCT
TAACGCCAAAGCGGCGGTCTTTGCGGTGAAAACGGAGTTCGAAGCGCTGGGCGTTGAACTGCCGATAATGATCTCCGGCA
CCATCACTGACGCCTCCGGGCGCACGCTCTCCGGGCAGACCACCGAAGCATTTTACAACTCATTGCGCCACGCCGAAGCG
CTAACCTTTGGCCTGAACTGTGCGCTGGGGCCCGATGAACTGCGCCAGTACGTGCAGGAGCTGTCACGGATTGCGGAGTG
CTACGTCACCGCGCACCCGAACGCTGGGCTGCCCAACGCCTTTGGTGAATACGATCTCGACGCCGACACGATGGCAAAAC
AAATACGTGAATGGGCAGAAGCGGGATTCCTGAATATTGTTGGCGGCTGCTGCGGCACCACGCCACAACATATTGCAGCG
ATGAGCCGTGCTGTAGAAGGATTAGCGCCGCGCAAACTGCCGGAAATTCCTGTAGCCTGCCGTTTGTCTGGCCTGGAGCC
GCTGAACATTGGCGACGATAGCCTGTTTGTGAACGTGGGTGAACGCACCAACGTCACAGGTTCCGCTAAGTTCAAGCGCC
TGATCAAAGAAGAGAAATACAGCGAGGCGTTGGATGTGGCGCGTCAGCAGGTGGAAAACGGCGCGCAGATTATCGATATC
AACATGGATGAAGGGATGCTCGACGCCGAAGCGGCGATGGTGCGTTTTCTCAATCTGATTGCCGGTGAACCGGATATCGC
TCGCGTGCCGATTATGATCGACTCCTCAAAATGGGACGTCATTGAAAAAGGTCTGAAGTGTATCCAGGGCAAAGGCATTG
TTAACTCTATCTCGATGAAAGAGGGCGTCGACGCCTTTATCCATCACGCGAAACTGTTGCGTCGCTACGGTGCGGCAGTC
GTGGTAATGGCCTTTGACGAACAGGGCCAGGCCGATACCCGCGCACGGAAAATCGAGATTTGCCGTCGGGCGTACAAAAT
CCTCACCGAAGAGGTTGGCTTCCCGCCAGAAGATATCATCTTTGACCCGAACATCTTCGCGGTCGCAACTGGCATTGAAG
AGCACAACAACTACGCACAGGACTTTATCGGCGCGTGTGAAGACATCAAACGTGAACTGCCGCACGCGCTGATCTCCGGC
GGTGTTTCTAACGTTTCTTTCTCATTCCGTGGCAACGATCCGGTGCGCGAAGCCATTCACGCGGTGTTCCTCTACTATGC
CATCCGTAACGGTATGGATATGGGGATAGTCAACGCCGGGCAACTGGCGATTTACGACGACCTACCCGCTGAACTGCGCG
ACGCGGTGGAAGATGTGATTCTTAATCGTCGCGACGATGGCACCGAGCGTTTACTGGAGCTTGCCGAGAAATATCGCGGC
AGCAAAACCGACGACACCGCCAACGCCCAGCAGGCGGAGTGGCGCTCGTGGGAAGTGAATAAACGCCTGGAGTACTCGCT
GGTCAAAGGTATTACCGAATTTATTGAACAGGACACCGAAGAAGCCCGTCAGCAGGCTACGCGCCCGATTGAAGTGATTG
AAGGCCCGTTGATGGACGGCATGAACGTGGTCGGCGATCTGTTTGGCGAAGGCAAAATGTTCCTGCCGCAGGTGGTCAAA
TCGGCGCGTGTGATGAAGCAGGCGGTGGCTTACCTCGAACCATTCATAGAAGCCAGCAAAGAGCAGGGCAAAACTAATGG
CAAGATGGTGATCGCTACAGTGAAGGGTGACGTCCACGACATCGGTAAAAATATCGTTGGCGTGGTGCTGCAATGTAACA
ACTACGAAATTGTTGATCTCGGCGTTATGGTGCCGGCGGAAAAAATTCTCCGCACCGCCAAAGAAGTGAATGCTGATTTG
ATTGGCCTTTCGGGGCTTATCACGCCGTCGCTGGATGAAATGGTTAACGTGGCGAAAGAGATGGAGCGTCAGGGTTTCAC
CATTCCGTTACTGATCGGCGGCGCGACCACCTCTAAAGCGCACACGGCGGTGAAAATCGAGCAAAACTACAGTGGCCCGA
CGGTGTATGTGCAGAACGCCTCACGCACCGTTGGTGTGGTGGCGGCGCTGCTTTCTGACACTCAGCGTGATGATTTTGTC
GCTCGTACCCGTAAAGAGTACGAAACCGTACGTATTCAACATGGGCGCAAGAAACCGCGCACACCGCCAGTCACGCTGGA
AGCGGCGCGCGATAACGACTTCGCTTTTGACTGGCAGGCTTATACGCCGCCGGTGGCGCACCGTCTCGGCGTGCAGGAAG
TGGAAGCCAGCATCGAAACGCTGCGTAATTACATCGACTGGACGCCGTTCTTTATGACCTGGTCACTGGCTGGGAAGTAT
CCGCGCATTCTGGAAGATGAAGTGGTGGGTGAAGAGGCGAAGCGCCTGTTTAAAGACGCCAATGACATGCTGGATAAATT
AAGCGCCGAAAAAACGCTGAATCCACGTGGCGTGGTGGGCCTGTTCCCGGCAAACCGTGTGGGCGATGACATTGAAATCT
ACCGTGACGAAACGCGTACACATGTAATCAACGTCAGCCACCATCTGCGTCAACAGACCGAAAAAACGGGCTTCGCTAAC
TACTGTCTCGCTGACTTCGTTGCGCCGAAGCTTTCTGGTAAAGCAGATTACATTGGCGCATTTGCTGTGACCGGCGGGCT
GGAAGAGGACGCACTGGCTGATGCCTTCGAAGCACAGCACGATGATTACAACAAAATAATGGTGAAAGCGCTTGCCGACC
GTTTAGCCGAAGCGTTTGCGGAGTATCTCCATGAGCGTGTGCGTAAAGTCTACTGGGGCTATGCGCCGAACGAGAACCTC
AGCAACGAAGAGCTGATCCGCGAAAACTATCAGGGAATCCGCCCGGCACCAGGCTACCCGGCCTGCCCTGAACATACGGA
AAAAGCCACCATCTGGGAGCTGCTGGAAGTGGAAAAACACACCGGCATGAAACTCACGGAATCTTTCGCGATGTGGCCGG
GAGCTTCGGTTTCGGGTTGGTACTTCAGCCACCCGGACAGCAAGTATTACGCGGTAGCGCAAATTCAGCGCGATCAGGTC
GAAGACTATGCCCGCCGTAAAGGTATGAGCGTCTCAGATGTTGAACGCTGGCTGGCACCGAATCTGGGGTATGACGCCGA
GTAA

Upstream 100 bases:

>100_bases
TCTCATGTTGCGTGGTGCTCGCTTTTACCACAGATGCGTTTATGCCAGTATGGTTTGTTGAATTTTTATTAAATCTGGGT
TGAGCGTGTCGGGAGCAAGT

Downstream 100 bases:

>100_bases
ATGATAATACCGGGGTATTTGCCCCGGTATTTAATGTCATAAATAATGGATTATTGAAAATGATAAAAATTGATGAAATA
GATTTTTTCGCTTTCGAAGG

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS [H]

Number of amino acids: Translated: 1227; Mature: 1226

Protein sequence:

>1227_residues
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIAAIHNAYFEAGADIIE
TNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLV
AAYRESTKALVEGGADLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLNIVGGCCGTTPQHIAA
MSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDI
NMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISG
GVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRG
SKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADL
IGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFV
ARTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAKRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFAN
YCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENL
SNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVSDVERWLAPNLGYDAE

Sequences:

>Translated_1227_residues
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIAAIHNAYFEAGADIIE
TNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLV
AAYRESTKALVEGGADLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLNIVGGCCGTTPQHIAA
MSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDI
NMDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISG
GVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRG
SKTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADL
IGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFV
ARTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGEEAKRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFAN
YCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENL
SNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVSDVERWLAPNLGYDAE
>Mature_1226_residues
SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSKPEVIAAIHNAYFEAGADIIET
NTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTARTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVA
AYRESTKALVEGGADLILIETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEAL
TFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAEAGFLNIVGGCCGTTPQHIAAM
SRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVGERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDIN
MDEGMLDAEAAMVRFLNLIAGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAVV
VMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQDFIGACEDIKRELPHALISGG
VSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAGQLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGS
KTDDTANAQQAEWRSWEVNKRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVKS
ARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDLGVMVPAEKILRTAKEVNADLI
GLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKAHTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVA
RTRKEYETVRIQHGRKKPRTPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYP
RILEDEVVGEEAKRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFANY
CLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLS
NEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVE
DYARRKGMSVSDVERWLAPNLGYDAE

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1252, Percent_Identity=53.9137380191693, Blast_Score=1319, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1227, Percent_Identity=99.3480032599837, Blast_Score=2524, Evalue=0.0,
Organism=Escherichia coli, GI1786456, Length=329, Percent_Identity=24.0121580547112, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17535405, Length=1251, Percent_Identity=53.0775379696243, Blast_Score=1287, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 136072; Mature: 135941

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
CCHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
CHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEH
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
HHHHHHHCCCEEEEEEEEHHHHHCEEEEEEEEEEEECCCCCEECCCHHHHHHHHHHHHHH
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE
HHCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVG
CCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCCCCCCCCEEEECC
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
CCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCEE
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCEEEEECCHHHCCHHH
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEECCC
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
CEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCC
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHCHHHHHHHHHCCCCCHHHHHHH
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHEEEEEEECCEEEEEE
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
EEECCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
EEEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
CCCEEEEECCCCCCEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PRILEDEVVGEEAKRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHEEECCCCE
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
EEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHCC
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
CCCCCCCHHHHHHHHHHHHHCCCEEHHHHHCCCCCCCCCCEEECCCCCEEEEHHHHHHHH
EDYARRKGMSVSDVERWLAPNLGYDAE
HHHHHHCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
CHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
CHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDQLVAAYRESTKALVEGGADLILI
CCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEH
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
HHHHHHHCCCEEEEEEEEHHHHHCEEEEEEEEEEEECCCCCEECCCHHHHHHHHHHHHHH
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAE
HHCCCCCCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGDDSLFVNVG
CCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCCCCCCCCEEEECC
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHH
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
CCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHCCCEE
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCEEEEECCHHHCCHHH
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
HHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEECCC
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
CEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCCCCCCCC
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHCHHHHHHHHHCCCCCHHHHHHH
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHEEEEEEECCEEEEEE
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
EEECCHHHHHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCC
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
EEEEEEECCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCC
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
CCCEEEEECCCCCCEEECCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCC
PRILEDEVVGEEAKRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHEEECCCCE
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
EEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHCC
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCC
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
CCCCCCCHHHHHHHHHHHHHCCCEEHHHHHCCCCCCCCCCEEECCCCCEEEEHHHHHHHH
EDYARRKGMSVSDVERWLAPNLGYDAE
HHHHHHCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2185137; 2668277; 8369296; 8265357; 9278503; 1593636; 7992050; 8939751 [H]