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The map label for this gene is lldD [H]

Identifier: 218550883

GI number: 218550883

Start: 3689353

End: 3690543

Strand: Direct

Name: lldD [H]

Synonym: EFER_3599

Alternate gene names: 218550883

Gene position: 3689353-3690543 (Clockwise)

Preceding gene: 218550882

Following gene: 218550884

Centisome position: 80.4

GC content: 54.91

Gene sequence:

>1191_bases
ATGATTATTTCAGCAGCCAGCGATTATCGCGCCGCAGCGCAACGCATTTTGCCCCCTTTCTTATTCCACTACATCGACGG
TGGCGCTTATGCGGAATACACCTTGCGCCGTAACGTGGAAGATTTATCCCAGGTGGCACTACGCCAGCGTGTTCTGAAAA
ATATGTCTGATTTAAGCCTGGAAACCACGCTGTTTAATGAAAAACTGTCGATGCCAGTTGCACTTGCACCTGTCGGATTA
TGCGGCATGTACGCGCGGCGCGGTGAAGTGCAGGCCGCAGGCGCTGCAGATGCGCACGGTATCCCCTTTACGCTATCGAC
TGTTTCGGTCTGCCCAATTGAAGAAGTTGCACCAACCATTAAGCGCCCGATGTGGTTCCAGTTGTATGTGCTGCGCGATC
GCGGCTTTATGCGTAACGCGCTGGAGCGAGCAAAAGCAGCAGGCTGCTCGACGCTGGTTTTCACCGTGGATATGCCAACG
CCTGGCGCGCGTTACCGTGATGCGCACTCCGGTATGAGCGGCCCGAACGCAGCAATGCGCCGTTACTGGCAGGCGGTGAC
GCATCCGCAATGGGCGTGGGATGTGGGCCTGAATGGTCGTCCACATGATCTCGGTAATATCTCGGCTTACCTCGGCAAAC
CAACCGGACTGGAAGATTACATCGGCTGGCTGGCTAATAACTTCGATCCCTCGATCTCATGGAAAGACCTTGAATGGATC
CGCGACTTCTGGGATGGCCCGATGGTGATCAAAGGAATCCTTGATCCAGAAGATGCGCGTGATGCGGTACGTTTTGGCGC
AGATGGCATTGTGGTTTCTAACCACGGTGGTCGCCAGCTGGACGGTGTACTCTCTTCTGCCCGCGCACTCCCTGCTATTG
CGGATGCAGTGAAAGGTGATATCGCCATTCTGGCAGATAGCGGGATTCGTAACGGGCTGGACGTGGTACGCATGATTGCC
CTCGGTGCCGATACCGTACTGCTGGGTCGTGCATATCTTTACGCCCTGGCGACGGCTGGTAAGGCGGGCGTGGCTAATTT
ACTCAATTTGATCGAAAAAGAGATGAAAGTCGCAATGACGCTGACAGGTGCGAAGTCGATCAGTGAAATTAGTCAGGATT
CGCTGGTGCAGGAGTTGGATAAAGCACTGCCTGCGGCGCTGGCTCCACTGGCGAAAGGGAATGCAGCTTAA

Upstream 100 bases:

>100_bases
TCCACACCACCATTAAACGATTTGATGAAGACCAGGCCCGCCAGGCACGTATTACCCGTCTGCCCGGTGACCAGAATGAT
ATTTCCAGGGAGAACGAAGC

Downstream 100 bases:

>100_bases
GGGTTAGATGAATATCTGCTATCCTGCCCCCGCACTAAGGGGGCAGTATGCTAAACATCGTACTTTACGAACCAGAAATT
CCGCCAAACACTGGCAACAT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNEKLSMPVALAPVGL
CGMYARRGEVQAAGAADAHGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKAGVANLLNLIEKEMKVAMTLTGAKSISEISQDSLVQELDKALPAALAPLAKGNAA

Sequences:

>Translated_396_residues
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNEKLSMPVALAPVGL
CGMYARRGEVQAAGAADAHGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKAGVANLLNLIEKEMKVAMTLTGAKSISEISQDSLVQELDKALPAALAPLAKGNAA
>Mature_396_residues
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSLETTLFNEKLSMPVALAPVGL
CGMYARRGEVQAAGAADAHGIPFTLSTVSVCPIEEVAPTIKRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPT
PGARYRDAHSGMSGPNAAMRRYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGDIAILADSGIRNGLDVVRMIA
LGADTVLLGRAYLYALATAGKAGVANLLNLIEKEMKVAMTLTGAKSISEISQDSLVQELDKALPAALAPLAKGNAA

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=367, Percent_Identity=33.5149863760218, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI54234014, Length=380, Percent_Identity=34.4736842105263, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI7705393, Length=380, Percent_Identity=34.4736842105263, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI1790033, Length=396, Percent_Identity=96.2121212121212, Blast_Score=778, Evalue=0.0,
Organism=Caenorhabditis elegans, GI193208036, Length=371, Percent_Identity=34.5013477088949, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI32566217, Length=284, Percent_Identity=32.3943661971831, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6323587, Length=382, Percent_Identity=28.0104712041885, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI78707188, Length=382, Percent_Identity=34.2931937172775, Blast_Score=207, Evalue=9e-54,
Organism=Drosophila melanogaster, GI281363140, Length=382, Percent_Identity=34.2931937172775, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI78707190, Length=382, Percent_Identity=34.2931937172775, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 42782; Mature: 42782

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSL
CEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNEKLSMPVALAPVGLCGMYARRGEVQAAGAADAHGIPFTLSTVSVCPIEEVAPTI
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
IAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKAGVANLLNLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHE
LTGAKSISEISQDSLVQELDKALPAALAPLAKGNAA
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIISAASDYRAAAQRILPPFLFHYIDGGAYAEYTLRRNVEDLSQVALRQRVLKNMSDLSL
CEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCH
ETTLFNEKLSMPVALAPVGLCGMYARRGEVQAAGAADAHGIPFTLSTVSVCPIEEVAPTI
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCEEECCHHHHHHHH
KRPMWFQLYVLRDRGFMRNALERAKAAGCSTLVFTVDMPTPGARYRDAHSGMSGPNAAMR
CCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RYWQAVTHPQWAWDVGLNGRPHDLGNISAYLGKPTGLEDYIGWLANNFDPSISWKDLEWI
HHHHHHCCCCCEEECCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHH
RDFWDGPMVIKGILDPEDARDAVRFGADGIVVSNHGGRQLDGVLSSARALPAIADAVKGD
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCC
IAILADSGIRNGLDVVRMIALGADTVLLGRAYLYALATAGKAGVANLLNLIEKEMKVAMT
EEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHE
LTGAKSISEISQDSLVQELDKALPAALAPLAKGNAA
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA