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The map label for this gene is mtlD [H]

Identifier: 218550875

GI number: 218550875

Start: 3677268

End: 3678416

Strand: Direct

Name: mtlD [H]

Synonym: EFER_3591

Alternate gene names: 218550875

Gene position: 3677268-3678416 (Clockwise)

Preceding gene: 218550874

Following gene: 218550876

Centisome position: 80.14

GC content: 52.31

Gene sequence:

>1149_bases
ATGAAAGCATTACATTTTGGCGCAGGTAATATCGGTCGTGGTTTTATCGGTAAACTGCTGGCAGACGCGGGTATCCAACT
GACGTTTGCCGATGTCAATCAGGTGGTACTTGATGCCCTGAATGCCCGTCATAGCTATCAGGTTCATGTGGTCGGTGAAA
CCGAGCAGGTAGATACCGTTTCCGGTGTTAATGCCGTCAGCAGCATTGGTAATGATGTCGTTGATCTGATTGCTCAGGTC
GATTTAGTCACTACCGCTGTTGGCCCGGTTGTGCTGGAACGTATTGCCCCGGCAATCGCCAAAGGGCTGGTGAAACGTAA
AGAACAAGGTAATGAATCCCCACTGAACATTATCGCCTGTGAAAACATGGTACGCGGCACCACGCAGCTGAAAGGCCATG
TGATGAACGCCCTGCCGGAAGACGCCAAAGCGTGGGTAGAAGAACACGTTGGCTTTGTCGATTCCGCGGTTGACCGCATC
GTACCGCCTTCGGCTTCGGCAACCAACGATCCGCTGGAAGTGACGGTAGAAACCTTCAGCGAATGGATTGTTGATAAAAC
CCAGTTCAAAGGCGCGCTGCCGAACATTCCAGGCATGGAGTTAACCGACAACCTGATGGCATTTGTCGAACGTAAACTCT
TCACCCTGAACACGGGTCATGCTATAACCGCGTACCTCGGAAAACTGGCGGGTCATCAGACCATTCGTGATGCGATTCTC
GACGCGAAAATCCGCGCGGTGGTAAAAGGGGCGATGGAAGAAAGCGGCGCGGTACTGATTAAACGTTACGGTTTTGACGC
GGACAAACATGCGGCGTACATCCAGAAAATCCTTGGTCGTTTTGAGAACCCGTATCTGAAAGATGATGTAGAGCGCGTAG
GCCGTCAGCCGCTGCGTAAACTGAGCGCAGGCGACCGTCTGATCAAGCCACTGCTGGGTACGCTGGAATATGGTCTGCCA
CATAAAAACCTGATTGAAGGTATTGCCGCTGCAATGCACTTCCGCAGTGAAGATGATCCGCAGGCTCAGGAACTGGCAGC
ACTGATCGCTGACAAAGGCCCGCAAGCCGCACTGGCAGAGATTTCCGGGCTTGATGCTAACAGCGATGTCGTCATTGAGG
CGGTACGCGTTTATAACGAAAAGCAATGA

Upstream 100 bases:

>100_bases
AAGTAATCCAACCCTACCCTCTCCTCACGGAGAGGGTTTGGGTGAGGGAAAAGCCTCACCCCAGCCCTCTCGGGTAAAAA
CATTGATGAAGGTTAATACT

Downstream 100 bases:

>100_bases
TGTAAGACCAGGCCGCAGGGTAACCTGCGCCTGAAACATAGATTGTCAGATATGCAGGCAACAATGGAACAAACCCAGGC
CTTTGAAAACCGTGTGCTGG

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVNAVSSIGNDVVDLIAQV
DLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRI
VPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DAKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HKNLIEGIAAAMHFRSEDDPQAQELAALIADKGPQAALAEISGLDANSDVVIEAVRVYNEKQ

Sequences:

>Translated_382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVNAVSSIGNDVVDLIAQV
DLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRI
VPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DAKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HKNLIEGIAAAMHFRSEDDPQAQELAALIADKGPQAALAEISGLDANSDVVIEAVRVYNEKQ
>Mature_382_residues
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTVSGVNAVSSIGNDVVDLIAQV
DLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIACENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRI
VPPSASATNDPLEVTVETFSEWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
DAKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRKLSAGDRLIKPLLGTLEYGLP
HKNLIEGIAAAMHFRSEDDPQAQELAALIADKGPQAALAEISGLDANSDVVIEAVRVYNEKQ

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790028, Length=382, Percent_Identity=97.1204188481675, Blast_Score=754, Evalue=0.0,
Organism=Escherichia coli, GI1788497, Length=232, Percent_Identity=28.8793103448276, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1787823, Length=267, Percent_Identity=28.0898876404494, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790779, Length=259, Percent_Identity=28.1853281853282, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324401, Length=234, Percent_Identity=28.6324786324786, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320765, Length=234, Percent_Identity=28.6324786324786, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.17 [H]

Molecular weight: Translated: 41203; Mature: 41203

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00974 MANNITOL_DHGENASE ; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTV
CCCEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
SGVNAVSSIGNDVVDLIAQVDLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
ENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
EWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DAKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRK
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYGLPHKNLIEGIAAAMHFRSEDDPQAQELAALIADKGPQAALAE
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHH
ISGLDANSDVVIEAVRVYNEKQ
HHCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKALHFGAGNIGRGFIGKLLADAGIQLTFADVNQVVLDALNARHSYQVHVVGETEQVDTV
CCCEECCCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
SGVNAVSSIGNDVVDLIAQVDLVTTAVGPVVLERIAPAIAKGLVKRKEQGNESPLNIIAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEH
ENMVRGTTQLKGHVMNALPEDAKAWVEEHVGFVDSAVDRIVPPSASATNDPLEVTVETFS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHH
EWIVDKTQFKGALPNIPGMELTDNLMAFVERKLFTLNTGHAITAYLGKLAGHQTIRDAIL
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
DAKIRAVVKGAMEESGAVLIKRYGFDADKHAAYIQKILGRFENPYLKDDVERVGRQPLRK
HHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LSAGDRLIKPLLGTLEYGLPHKNLIEGIAAAMHFRSEDDPQAQELAALIADKGPQAALAE
HHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHH
ISGLDANSDVVIEAVRVYNEKQ
HHCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA