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The map label for this gene is lyxK [H]

Identifier: 218550862

GI number: 218550862

Start: 3662386

End: 3663882

Strand: Direct

Name: lyxK [H]

Synonym: EFER_3578

Alternate gene names: 218550862

Gene position: 3662386-3663882 (Clockwise)

Preceding gene: 218550861

Following gene: 218550863

Centisome position: 79.81

GC content: 56.98

Gene sequence:

>1497_bases
ATGACGCAATACTGGCTGGGGTTAGATTGTGGCGGTAGCTGGCTGAAAGCCGGCCTGTATGACCGCGAAGGCCGGGAGGC
AGGCGTGCAGCGCCTGCCGCTGTGCGCATTAAGCCCGCAGCCAGGCTGGGCAGAGCGCGATATGGCAGAACTGTGGCAAT
GCTGCATGGCTGTCATTCGCTCCCTGCTTACCCATTCCAGCGTTAGCGGGGAGCAAATTGTCGGCATCGGTATCTCCGCA
CAGGGAAAGGGCTTGTTTTTGCTGGATAAAAACGACAAGCCGCTCGGTAACGCCATTTTGTCCTCGGATCGCCGGGCGAT
GGAAATCGTTCGTCGCTGGCAGGAAGATAGCATCCCGGAAAAACTCTACCCGCTGACCCGACAAACCTTGTGGACCGGGC
ATCCGGTGTCGCTGTTACGCTGGCTGAAAGAGCACGAACCAGAACGCTACGCGCAAATTGGCTGCGTGATGATGACGCAC
GACTACCTGCGCTGGTGTTTAACCGGTGTCAAAGGCTGCGAAGAGAGCAATATTTCCGAATCCAATCTCTACAACATGAG
TCTTGGGGAATATGACCCGTGCCTCACCGACTGGCTGGGGATCAGTGAAATCAATCTCGCCCTGCCGCCTGTTGTCGGAT
CTGCCGAAATCTGCGGGGAAATCACCGCTCAGACAGCCGCACTGACCGGTCTGAAAGCGGGTACGCCCGTTGTCGGCGGC
CTGTTTGATGTGGTTTCTACCGCACTCTGCGCCGGAATCGAAGACGAATTTACCCTCAATGCGGTGATGGGGACCTGGGC
GGTGACCAGCGGCATAACCAGCGGTTTAGGTGACGGTGAAGCGCATCCGTATGTCTATGGCCGCTACGTTAACGACGATG
AATTTATCGTTCACGAAGCCAGCCCTACGTCTTCCGGCAATCTCGAATGGTTTACCGCGCAGTGGGGAGAAATCTCGTTT
GCTGAGATCAACCAGGCTGTTGTCAGCTTACCGAAAGCCGGTGGCGATCTCTTTTTCCTGCCGTTCCTGTACGGCAGCAA
CGCCGGACTTGAGATGACCAGCGGTTTCTACGGGATGCAGGCTATTCACACCCGCGCGCACCTGTTGCAGGCCATCTATG
AAGGGGTGGTGTTCAGCCATATGACCCATCTCAACCGGATGCGCGAACGTTTTACTGATGTTCACACCCTGCGCGTGACT
GGTGGCCCGGCGCACTCCGATGTCTGGATGCAAATGCTGGCGGACGTCAGCGGCTTACGTATCGAACTGCCGCAGGTGGA
AGAAACCGGCTGTTTTGGCGCGGCGCTTGCAGCCCGCGTCGGCACCGGTGTTTATCGCGATTTCAGTGAAGCCCAGCGCG
ATCAACAGCACCCGGTGCGCACCCTGTTACCGGATATGACCGCCCATCAGCTTTACCAACAAAAATACCAACGCTATCAG
CACCTCATTGCCGCACTACAGGGCTTTCATGCCCGCGTTAAGGAGAACACATTATGA

Upstream 100 bases:

>100_bases
CTTTAGCGACGCTCTGGGTACTCAGGTCCGCGACATGTTTGTAAAAGATGTTCCGCAGGGCGCTGACCTGCTGAAAGCCG
TGGATGAGGTGCAATAAGCC

Downstream 100 bases:

>100_bases
GCAGACCACTTCTGCAACTGGCCCTCGACCACTCATCACTTGAAGCCGCACAGCGCGACGTTGCGCTGTTAAAAGACAGC
GTCGATATCGTCGAAGCGGG

Product: L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRSLLTHSSVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDSIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGISEINLALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITSGLGDGEAHPYVYGRYVNDDEFIVHEASPTSSGNLEWFTAQWGEISF
AEINQAVVSLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDQQHPVRTLLPDMTAHQLYQQKYQRYQ
HLIAALQGFHARVKENTL

Sequences:

>Translated_498_residues
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRSLLTHSSVSGEQIVGIGISA
QGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDSIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTH
DYLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGISEINLALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITSGLGDGEAHPYVYGRYVNDDEFIVHEASPTSSGNLEWFTAQWGEISF
AEINQAVVSLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVT
GGPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDQQHPVRTLLPDMTAHQLYQQKYQRYQ
HLIAALQGFHARVKENTL
>Mature_497_residues
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIRSLLTHSSVSGEQIVGIGISAQ
GKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDSIPEKLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHD
YLRWCLTGVKGCEESNISESNLYNMSLGEYDPCLTDWLGISEINLALPPVVGSAEICGEITAQTAALTGLKAGTPVVGGL
FDVVSTALCAGIEDEFTLNAVMGTWAVTSGITSGLGDGEAHPYVYGRYVNDDEFIVHEASPTSSGNLEWFTAQWGEISFA
EINQAVVSLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQAIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTG
GPAHSDVWMQMLADVSGLRIELPQVEETGCFGAALAARVGTGVYRDFSEAQRDQQHPVRTLLPDMTAHQLYQQKYQRYQH
LIAALQGFHARVKENTL

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI88196792, Length=492, Percent_Identity=24.7967479674797, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI164663828, Length=542, Percent_Identity=23.2472324723247, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790005, Length=498, Percent_Identity=96.5863453815261, Blast_Score=999, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=511, Percent_Identity=25.0489236790607, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI1789987, Length=494, Percent_Identity=23.8866396761134, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790361, Length=475, Percent_Identity=23.1578947368421, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1789168, Length=476, Percent_Identity=21.8487394957983, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656367, Length=523, Percent_Identity=23.1357552581262, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21357867, Length=535, Percent_Identity=22.2429906542056, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24655555, Length=463, Percent_Identity=23.3261339092873, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24655560, Length=463, Percent_Identity=23.3261339092873, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24655570, Length=463, Percent_Identity=23.3261339092873, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24655574, Length=463, Percent_Identity=23.3261339092873, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24655565, Length=463, Percent_Identity=23.3261339092873, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24656372, Length=167, Percent_Identity=28.1437125748503, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 55067; Mature: 54936

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00445 FGGY_KINASES_2 ; PS00591 GLYCOSYL_HYDROL_F10

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
CCCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHH
SLLTHSSVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDSIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SNLYNMSLGEYDPCLTDWLGISEINLALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
CCEEECCCCCCCCHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITSGLGDGEAHPYVYGRYVNDDEFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEC
SPTSSGNLEWFTAQWGEISFAEINQAVVSLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCEEHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEECCCCHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDQQHPVRTLLPDMTAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHH
HLIAALQGFHARVKENTL
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQYWLGLDCGGSWLKAGLYDREGREAGVQRLPLCALSPQPGWAERDMAELWQCCMAVIR
CCEEEEECCCCHHHHCCCCCCCCHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHH
SLLTHSSVSGEQIVGIGISAQGKGLFLLDKNDKPLGNAILSSDRRAMEIVRRWQEDSIPE
HHHHCCCCCCCEEEEEEEECCCCEEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHCCCCH
KLYPLTRQTLWTGHPVSLLRWLKEHEPERYAQIGCVMMTHDYLRWCLTGVKGCEESNISE
HHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SNLYNMSLGEYDPCLTDWLGISEINLALPPVVGSAEICGEITAQTAALTGLKAGTPVVGG
CCEEECCCCCCCCHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LFDVVSTALCAGIEDEFTLNAVMGTWAVTSGITSGLGDGEAHPYVYGRYVNDDEFIVHEA
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEEC
SPTSSGNLEWFTAQWGEISFAEINQAVVSLPKAGGDLFFLPFLYGSNAGLEMTSGFYGMQ
CCCCCCCEEEEECCCCCEEHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEECCCCHHHH
AIHTRAHLLQAIYEGVVFSHMTHLNRMRERFTDVHTLRVTGGPAHSDVWMQMLADVSGLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCCCE
IELPQVEETGCFGAALAARVGTGVYRDFSEAQRDQQHPVRTLLPDMTAHQLYQQKYQRYQ
EECCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHH
HLIAALQGFHARVKENTL
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]