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The map label for this gene is lysA [H]

Identifier: 218550088

GI number: 218550088

Start: 2839610

End: 2840872

Strand: Reverse

Name: lysA [H]

Synonym: EFER_2773

Alternate gene names: 218550088

Gene position: 2840872-2839610 (Counterclockwise)

Preceding gene: 218550090

Following gene: 218550086

Centisome position: 61.91

GC content: 52.73

Gene sequence:

>1263_bases
ATGCCACACTTACTGACCTGTGCTGCCAGTGATTTGACCGCTGAAAATCTGCTGACACTGCCTGCCGAATTTGGTTGCCC
GGTATGGGTATACGATGCACAAATCATCCGCCGACAGATCGCGGCACTGAAGCAGTTTGATGTGGTGCGCTTTGCCCAGA
AGGCATGTTCCAATATTCATATTCTACGTCTGATGCGTGAGCAAGGAGTGAAGGTTGATTCCGTATCGCTGGGCGAGATC
GAACGAGCATTGGCTGCCGGGTACGATCCTTTGACTTCACCGGACGATATTGTCTTTACCGCTGATGTGATTGATAGCGC
GACTCTGGCACGGGTCAGCGAGCTGCGTATTCCGGTAAATGCCGGATCTGTCGATATGCTGGAGCAATTAGGGCAGGTTT
CGCCAGGGCATCGTGTCTGGCTGCGGGTCAATCCTGGCTTTGGTCACGGGCACAGCCAGAAAACGAACACCGGCGGCGAG
AACAGTAAGCATGGGATTTGGCATACCGATTTGCCTGCAGCACTGGCAGTGATTGCACGCTATGAGTTGAAACTTGTGGG
GATTCATATGCATATTGGTTCCGGTGTCGATTACGCGCATCTGGAACAGGTCTGTGGGGCTATGGTGAGTCAGGTCATTG
AGTTTGGTCAGGAGCTGGAGGCGATATCTGCTGGTGGTGGATTGTCGATCCCGTATCGTGACGGCGAAGAGGCCGTGGAT
ACCGAACACTATTTTGGTTTGTGGAATGCTGCTCGTGAGCAAATTGCTCATCATCTTGGGCATCGGGTGAAGCTGGAAAT
CGAACCAGGACGTTTTCTGGTAGCACAATCCGGCGTATTAATCGCCCAGGTACGAAGCGTGAAACAGATGGGGCGTCGCC
ACTTCGTGTTGATTGATGCAGGATTCAACGACTTAATGCGCCCTGCAATGTATGGCAGTTATCACCGAATTACTGCACTG
GCGGCAGACGGACGATCATTTGACAATACGCCAGTGGTGGAAACTGTAGTGGCGGGGCCGTTGTGTGAGTCCGGCGATGT
TTTCACGCAGCAGGAGGGGGGCACTGTCGAAACGCGTGAACTTCCACAAGTTGCGCCGGGTGATTATCTGGTATTGCATG
ACACGGGCGCCTATGGCGCATCGATGTCATCGAATTACAACAGCCGCCCGTTACTGCCAGAAGTACTGTTTGATAATGGT
CAGGCGCGGTTAATTCGTCGTCGCCAAACTATTGAGGAGTTACTGGCACTGGAGTTAATCTGA

Upstream 100 bases:

>100_bases
CAGCATTAATCCATATCATTTTTGCATAGACTTACGAAAAAACGATATTTTTTATTCGGTTTTTCCTGTGGCGTAATCAT
AAAAAAAAGAGGAGCCACAA

Downstream 100 bases:

>100_bases
GTGCCAGCTTGTGTTCAGTTGCTGGAAGCTGAATGACTGGCTTCCAGTGGCGGCGTCACGGAGTGCCTGCGCACCAGGGT
AGGGATGAAAACGTGCGTGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MPHLLTCAASDLTAENLLTLPAEFGCPVWVYDAQIIRRQIAALKQFDVVRFAQKACSNIHILRLMREQGVKVDSVSLGEI
ERALAAGYDPLTSPDDIVFTADVIDSATLARVSELRIPVNAGSVDMLEQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGE
NSKHGIWHTDLPAALAVIARYELKLVGIHMHIGSGVDYAHLEQVCGAMVSQVIEFGQELEAISAGGGLSIPYRDGEEAVD
TEHYFGLWNAAREQIAHHLGHRVKLEIEPGRFLVAQSGVLIAQVRSVKQMGRRHFVLIDAGFNDLMRPAMYGSYHRITAL
AADGRSFDNTPVVETVVAGPLCESGDVFTQQEGGTVETRELPQVAPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNG
QARLIRRRQTIEELLALELI

Sequences:

>Translated_420_residues
MPHLLTCAASDLTAENLLTLPAEFGCPVWVYDAQIIRRQIAALKQFDVVRFAQKACSNIHILRLMREQGVKVDSVSLGEI
ERALAAGYDPLTSPDDIVFTADVIDSATLARVSELRIPVNAGSVDMLEQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGE
NSKHGIWHTDLPAALAVIARYELKLVGIHMHIGSGVDYAHLEQVCGAMVSQVIEFGQELEAISAGGGLSIPYRDGEEAVD
TEHYFGLWNAAREQIAHHLGHRVKLEIEPGRFLVAQSGVLIAQVRSVKQMGRRHFVLIDAGFNDLMRPAMYGSYHRITAL
AADGRSFDNTPVVETVVAGPLCESGDVFTQQEGGTVETRELPQVAPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNG
QARLIRRRQTIEELLALELI
>Mature_419_residues
PHLLTCAASDLTAENLLTLPAEFGCPVWVYDAQIIRRQIAALKQFDVVRFAQKACSNIHILRLMREQGVKVDSVSLGEIE
RALAAGYDPLTSPDDIVFTADVIDSATLARVSELRIPVNAGSVDMLEQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGEN
SKHGIWHTDLPAALAVIARYELKLVGIHMHIGSGVDYAHLEQVCGAMVSQVIEFGQELEAISAGGGLSIPYRDGEEAVDT
EHYFGLWNAAREQIAHHLGHRVKLEIEPGRFLVAQSGVLIAQVRSVKQMGRRHFVLIDAGFNDLMRPAMYGSYHRITALA
ADGRSFDNTPVVETVVAGPLCESGDVFTQQEGGTVETRELPQVAPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQ
ARLIRRRQTIEELLALELI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=89.294403892944, Blast_Score=759, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45924; Mature: 45793

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHLLTCAASDLTAENLLTLPAEFGCPVWVYDAQIIRRQIAALKQFDVVRFAQKACSNIH
CCCEEEECCCCCCHHHHEECCHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMREQGVKVDSVSLGEIERALAAGYDPLTSPDDIVFTADVIDSATLARVSELRIPVN
HHHHHHHCCCEECCCCHHHHHHHHHCCCCCCCCCCCEEEEHHHHCCHHHHHHHHEEEECC
AGSVDMLEQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWHTDLPAALAVIAR
CCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
YELKLVGIHMHIGSGVDYAHLEQVCGAMVSQVIEFGQELEAISAGGGLSIPYRDGEEAVD
HEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
TEHYFGLWNAAREQIAHHLGHRVKLEIEPGRFLVAQSGVLIAQVRSVKQMGRRHFVLIDA
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCCCEEEEEEEC
GFNDLMRPAMYGSYHRITALAADGRSFDNTPVVETVVAGPLCESGDVFTQQEGGTVETRE
CHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCEECCCC
LPQVAPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQARLIRRRQTIEELLALELI
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PHLLTCAASDLTAENLLTLPAEFGCPVWVYDAQIIRRQIAALKQFDVVRFAQKACSNIH
CCEEEECCCCCCHHHHEECCHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ILRLMREQGVKVDSVSLGEIERALAAGYDPLTSPDDIVFTADVIDSATLARVSELRIPVN
HHHHHHHCCCEECCCCHHHHHHHHHCCCCCCCCCCCEEEEHHHHCCHHHHHHHHEEEECC
AGSVDMLEQLGQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWHTDLPAALAVIAR
CCCHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
YELKLVGIHMHIGSGVDYAHLEQVCGAMVSQVIEFGQELEAISAGGGLSIPYRDGEEAVD
HEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
TEHYFGLWNAAREQIAHHLGHRVKLEIEPGRFLVAQSGVLIAQVRSVKQMGRRHFVLIDA
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCHHHHHHHHHHCCCEEEEEEEC
GFNDLMRPAMYGSYHRITALAADGRSFDNTPVVETVVAGPLCESGDVFTQQEGGTVETRE
CHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEEECCCCEECCCC
LPQVAPGDYLVLHDTGAYGASMSSNYNSRPLLPEVLFDNGQARLIRRRQTIEELLALELI
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]