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The map label for this gene is yqeF [H]

Identifier: 218550090

GI number: 218550090

Start: 2841922

End: 2843103

Strand: Reverse

Name: yqeF [H]

Synonym: EFER_2775

Alternate gene names: 218550090

Gene position: 2843103-2841922 (Counterclockwise)

Preceding gene: 218550100

Following gene: 218550088

Centisome position: 61.96

GC content: 54.31

Gene sequence:

>1182_bases
ATGAAAGAGGTCGTGATAGTCGGGGCGTTGCGCACACCCATTGGATGTTTTCAGGGGGCGTTGTCACGTCATTCTGCGGT
CGAGCTGGGTAGCCGGGTAATACACGCCCTGCTGGAAAAAACAGGCGTGGATGGCAATGCCATTGATGAGGTGATTCTGG
GGCAGGTACTCACTGCCGGAGCAGGGCAAAACCCCGCCCGACAGTCAGCAATTAAAGGTGGCCTGCCGAATACCGTCTCA
GCTATAACTATCAACGACGTTTGCGGTTCCGGTCTGAAAGCGCTTCATCTTGCCACTCAGGCAATCCAGTGCGGCGAGGC
TGATATCGTTATTGCGGGCGGCCAGGAGAATATGAGCCGCGCGCCGCATGTATTGACCGATAGCCGAACTGGTGCGCAAC
TTGGTAACAGTCAACTGGTTGACAGCCTTGTGCATGACGGTTTGTGGGATGCGTTTAATGATTATCATATTGGCGTGACG
GCGGAAAATCTGGCGCGTGAATATGGTATCAGCCGTGAGTTACAGGATGCATACGCCCTGAGTTCCCAGCAAAAGGCACG
TGCTGCCATCGATAGTGGCCGATTCCAGGCTGAAATCGTACCGGTAGTCATCGAACGTGAAGGGCAGTTGCTGCGGGTCG
ATACCGATGAACAGCCACGTACCGATGCCAGTGCAGAAGGACTGGCACAGCTAAATCCTGCTTTTGAGCAGATGGGCTCG
GTCACTGCGGGCAATGCTTCTTCTATGAATGATGGCGCAGCGGCAGTCATGATGATGAGTGAAGCGAAAGCCCTGGAACT
TAATTTGCCGATCCTTGCGCGTATTCGTTCTTTTGCCAGTGTAGGGGTTGATCCGGCGCTGATGGGGATAGCCCCCGTTT
ATGCCACTCGTCGTTGCCTTGAACGTGTAGGCTGGCAGCTCGCGGATGTTGACCTGATTGAAGCAAATGAAGCTTTTGCT
GCTCAGGCATTATCGGTAGGGAAAATGCTGGAGTGGGATGAACGCCGGGTCAATGTTAACGGCGGTGCAATTGCTTTGGG
ACACCCTATAGGCGCATCGGGTTGCCGAATTCTGGTTTCCCTCGTCCATGAAATGGTCAAACGCAAAGCGCGTAAAGGGC
TGGCGACGCTTTGCATCGGCGGTGGTCAGGGCGTGGCTTTAACGATAGAGCGCGACGAATAA

Upstream 100 bases:

>100_bases
TGTAAATATCTTGTGATAAAAATCACCGTTTTTGCACAAACAAGATAACTGTCATTAACAATAATCTATTATTGGCGGGT
CAATTTGTGCAGAGGTCGTA

Downstream 100 bases:

>100_bases
GCCGTTAATGTTGCTTTGCACCTTGCAGGATGGCATCAAGTGAAGTTACCAGGCCCTGTAAGCTGGTTTGTAAGTGTTCA
CTAAAAGCATCGACCAGTGC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKEVVIVGALRTPIGCFQGALSRHSAVELGSRVIHALLEKTGVDGNAIDEVILGQVLTAGAGQNPARQSAIKGGLPNTVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRELQDAYALSSQQKARAAIDSGRFQAEIVPVVIEREGQLLRVDTDEQPRTDASAEGLAQLNPAFEQMGS
VTAGNASSMNDGAAAVMMMSEAKALELNLPILARIRSFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRKARKGLATLCIGGGQGVALTIERDE

Sequences:

>Translated_393_residues
MKEVVIVGALRTPIGCFQGALSRHSAVELGSRVIHALLEKTGVDGNAIDEVILGQVLTAGAGQNPARQSAIKGGLPNTVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRELQDAYALSSQQKARAAIDSGRFQAEIVPVVIEREGQLLRVDTDEQPRTDASAEGLAQLNPAFEQMGS
VTAGNASSMNDGAAAVMMMSEAKALELNLPILARIRSFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRKARKGLATLCIGGGQGVALTIERDE
>Mature_393_residues
MKEVVIVGALRTPIGCFQGALSRHSAVELGSRVIHALLEKTGVDGNAIDEVILGQVLTAGAGQNPARQSAIKGGLPNTVS
AITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSRAPHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVT
AENLAREYGISRELQDAYALSSQQKARAAIDSGRFQAEIVPVVIEREGQLLRVDTDEQPRTDASAEGLAQLNPAFEQMGS
VTAGNASSMNDGAAAVMMMSEAKALELNLPILARIRSFASVGVDPALMGIAPVYATRRCLERVGWQLADVDLIEANEAFA
AQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVSLVHEMVKRKARKGLATLCIGGGQGVALTIERDE

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=48.0818414322251, Blast_Score=367, Evalue=1e-102,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=43.4010152284264, Blast_Score=321, Evalue=8e-88,
Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=41.2658227848101, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI4501853, Length=396, Percent_Identity=40.4040404040404, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI4504327, Length=430, Percent_Identity=30.6976744186047, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI194353979, Length=396, Percent_Identity=30.3030303030303, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI87082165, Length=393, Percent_Identity=90.5852417302799, Blast_Score=725, Evalue=0.0,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=57.9081632653061, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=44.75, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=41.645885286783, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=32.3529411764706, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=42.8571428571429, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=41.2820512820513, Blast_Score=285, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17535921, Length=392, Percent_Identity=39.5408163265306, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=33.1632653061224, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=30.0469483568075, Blast_Score=175, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=396, Percent_Identity=42.6767676767677, Blast_Score=292, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=36.8686868686869, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=51.9181585677749, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=42.5641025641026, Blast_Score=306, Evalue=1e-83,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=42.1994884910486, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI17137578, Length=427, Percent_Identity=32.3185011709602, Blast_Score=182, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41341; Mature: 41341

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVVIVGALRTPIGCFQGALSRHSAVELGSRVIHALLEKTGVDGNAIDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPNTVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRELQDAYAL
CCCEEECCCCCHHCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHH
SSQQKARAAIDSGRFQAEIVPVVIEREGQLLRVDTDEQPRTDASAEGLAQLNPAFEQMGS
HHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEECCCCCCCCCCCCCCHHHCCHHHHHHCC
VTAGNASSMNDGAAAVMMMSEAKALELNLPILARIRSFASVGVDPALMGIAPVYATRRCL
CCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERVGWQLADVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHHCCEEECEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRKARKGLATLCIGGGQGVALTIERDE
HHHHHHHHHHHCCCEEEEEECCCEEEEEEECCC
>Mature Secondary Structure
MKEVVIVGALRTPIGCFQGALSRHSAVELGSRVIHALLEKTGVDGNAIDEVILGQVLTAG
CCCEEEEECHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
AGQNPARQSAIKGGLPNTVSAITINDVCGSGLKALHLATQAIQCGEADIVIAGGQENMSR
CCCCHHHHHHHCCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
APHVLTDSRTGAQLGNSQLVDSLVHDGLWDAFNDYHIGVTAENLAREYGISRELQDAYAL
CCCEEECCCCCHHCCHHHHHHHHHHCCHHHCCCCEEEEEEHHHHHHHHCCCHHHHHHHHH
SSQQKARAAIDSGRFQAEIVPVVIEREGQLLRVDTDEQPRTDASAEGLAQLNPAFEQMGS
HHHHHHHHHHHCCCCEEEEEEEEEECCCCEEEECCCCCCCCCCCCCCHHHCCHHHHHHCC
VTAGNASSMNDGAAAVMMMSEAKALELNLPILARIRSFASVGVDPALMGIAPVYATRRCL
CCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERVGWQLADVDLIEANEAFAAQALSVGKMLEWDERRVNVNGGAIALGHPIGASGCRILVS
HHHCCEEECEEEEECCHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCHHHHHHHH
LVHEMVKRKARKGLATLCIGGGQGVALTIERDE
HHHHHHHHHHHCCCEEEEEECCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]