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The map label for this gene is ppiD [H]

Identifier: 218549891

GI number: 218549891

Start: 2641735

End: 2643651

Strand: Reverse

Name: ppiD [H]

Synonym: EFER_2576

Alternate gene names: 218549891

Gene position: 2643651-2641735 (Counterclockwise)

Preceding gene: 218549892

Following gene: 218549890

Centisome position: 57.61

GC content: 49.45

Gene sequence:

>1917_bases
TTGCGTGAGGTATACAAGTCACCTACAGCGGAGTGTTGTTACACCATGATGGACAGCTTACGCACGGCTGCAAACAGTCT
CGTGCTCAAGATTATTTTCGGTATCATTATCGTGTCGTTCATTTTGACCGGCGTGAGTGGTTACCTGATTGGCGGAGGCA
ACAACTACGCCGCAAAAGTGAATGGCCAGGAAATCAGCCGTGGGCAATTCGAAAACGCGTTCAACAGCGAACGTAATCGA
ATGCAGCAGCAACTGGGCGATCAATACTCGGAGCTGGCAGCTAACGAAGGCTACATGAAGACGTTGCGCCAGCAGGTGTT
GAATCGTCTGATTGATGAGGCTCTGTTAGATCAATACTCCCGCGACCTGAAACTGGGAATCAGTGACGAGCAAGTCAAAC
AGGCGATCTTTGCCACCCCAGCCTTCCAGGTTGACGGTAAGTTTGATAACAGTCGCTACAATGCCATTCTTAATCAGATG
GGAATGAGTGCTGATCAATACGCACAGGCGCTACGTAACCAGCTGACCACGCAACAGTTGATTAACGGGATTGCCGGAAC
AGATTTCATGCTGAAAGGCGAAACTGACGAACTGGCAGCTCTGGTGTCTCAGCAACGCGTGGTTCGTGAAGCAACCATAG
ACGTTAATGCGAAAGCTGAAAAACAGCAGGTGAGTGATGCAGAAATCACCAGCTACTATGATCAGCATAAAAACAACTTC
GTGACACCGGAGCAATTCCGCGTTAGCTACATCATGCTGGATGCGGCAAACATACAGCAACCGGTTAGCGATGCAGATAT
CCAGGCTTATTACGACCAGCATCAGGATCAATTCACTCAGCCACAGCGTGTTCGCTATAGCATCATCCAGACCAAAACTG
AAAATGAAGCTAAAGCCGTGTTAGATGCGCTCAATAATGGTGGTGATTTTGCTGAGCTGGCGAAAGAGAAATCAGCCGAT
ATCATCTCCGCACGTAATGGCGGTGATCTGGGGTGGCTGGAAGATAGCACCACGCCGCAAGAGCTGAAAGACGCCGGGCT
GAAAGATAAAGGCCAGTTATCTGGGGTGATTAAATCTTCCGTAGGCTTCCTGGTGGTACGTCTGGATGACGTTCAACCGG
CCAAAGTAAAAACGTTAGCCGAAGTTCGTGATGACATCGCAGCGAAAGTGAAGCACGAAAAAGCGCTGGATGCTTATTAC
GCATTGCAACAGAAAGTTAGCGATGCCGCCAGCAACGATACTGAATCCCTGGCGGGTGCTGAGCAGGCGGCTGGAGTGAA
GGCAAAAGAAACTGGCTGGTTTAGCCAACAGAATCTGCCGGAAGAACTGAATTTCAAACCTGTTGCAGACGCTATCTTTA
GCGGTAGCCTGGTCGGAGAAAACGGCACTCCTGGTAGCAACTCAGATATCATCACTGTTGATGGCGATCGTGCCTTTGTG
CTTCGCGTTAGCGAACATAAAGCAGAAGCGATTAAACCGCTTTCTGAGGTGAAAGATCAGGTTAAGGCGCTGGTACAGCA
CGATAAAGCTGAACAGCAAGCGAAACTGGAAGCCGAAAAACTACTGGTTGAGTTGAAAGCAGGCAAAGGTGTAGACGCAA
TGCGGGCTGCTGGGTTGCAATTTGGCGAACAGAAAACCTTAAGCCGTTCTGGTCAGGACCCGGTTAGCCTGGCTGCGTTT
GCCTTAGGTTTGCCGGAGAAAGACAAGCCGAGCTACGGTATGGCAACCAATACGCAGGGTAATGTGGTATTGCTGGCACT
GGATGAAGTGAAAGCCGGTACGATGCCAGAAGCACAAAAACAAGCATTGGTTCAGGGGATCACCCAGAATAATGCTCAGA
TTGTTTTTGAAGCGCTGATGAGCAACCTGCGTAAAGAAGCAAAAATCAAAATTGGCGATGCGCTGGAACAGCAGTAA

Upstream 100 bases:

>100_bases
GATGTGCCTTTTTTATTTGTGATTCGGGACTTTATACCGCTTGTGGGCTGACAATTACCCCTGTTTCTTGTCACAATAGG
CCTTTGCGCGCAGCGATACG

Downstream 100 bases:

>100_bases
TTACGAGTCGCCTCGCAAATAATTGCACCAACTCTGTAACAACCAAAGGCCGCTTTCGCGGCCTTTTCCAAATCTGAAAA
TTGCCATTTGTACGCTTTTC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MREVYKSPTAECCYTMMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNGQEISRGQFENAFNSERNR
MQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYSRDLKLGISDEQVKQAIFATPAFQVDGKFDNSRYNAILNQM
GMSADQYAQALRNQLTTQQLINGIAGTDFMLKGETDELAALVSQQRVVREATIDVNAKAEKQQVSDAEITSYYDQHKNNF
VTPEQFRVSYIMLDAANIQQPVSDADIQAYYDQHQDQFTQPQRVRYSIIQTKTENEAKAVLDALNNGGDFAELAKEKSAD
IISARNGGDLGWLEDSTTPQELKDAGLKDKGQLSGVIKSSVGFLVVRLDDVQPAKVKTLAEVRDDIAAKVKHEKALDAYY
ALQQKVSDAASNDTESLAGAEQAAGVKAKETGWFSQQNLPEELNFKPVADAIFSGSLVGENGTPGSNSDIITVDGDRAFV
LRVSEHKAEAIKPLSEVKDQVKALVQHDKAEQQAKLEAEKLLVELKAGKGVDAMRAAGLQFGEQKTLSRSGQDPVSLAAF
ALGLPEKDKPSYGMATNTQGNVVLLALDEVKAGTMPEAQKQALVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ

Sequences:

>Translated_638_residues
MREVYKSPTAECCYTMMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNGQEISRGQFENAFNSERNR
MQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYSRDLKLGISDEQVKQAIFATPAFQVDGKFDNSRYNAILNQM
GMSADQYAQALRNQLTTQQLINGIAGTDFMLKGETDELAALVSQQRVVREATIDVNAKAEKQQVSDAEITSYYDQHKNNF
VTPEQFRVSYIMLDAANIQQPVSDADIQAYYDQHQDQFTQPQRVRYSIIQTKTENEAKAVLDALNNGGDFAELAKEKSAD
IISARNGGDLGWLEDSTTPQELKDAGLKDKGQLSGVIKSSVGFLVVRLDDVQPAKVKTLAEVRDDIAAKVKHEKALDAYY
ALQQKVSDAASNDTESLAGAEQAAGVKAKETGWFSQQNLPEELNFKPVADAIFSGSLVGENGTPGSNSDIITVDGDRAFV
LRVSEHKAEAIKPLSEVKDQVKALVQHDKAEQQAKLEAEKLLVELKAGKGVDAMRAAGLQFGEQKTLSRSGQDPVSLAAF
ALGLPEKDKPSYGMATNTQGNVVLLALDEVKAGTMPEAQKQALVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ
>Mature_638_residues
MREVYKSPTAECCYTMMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKVNGQEISRGQFENAFNSERNR
MQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYSRDLKLGISDEQVKQAIFATPAFQVDGKFDNSRYNAILNQM
GMSADQYAQALRNQLTTQQLINGIAGTDFMLKGETDELAALVSQQRVVREATIDVNAKAEKQQVSDAEITSYYDQHKNNF
VTPEQFRVSYIMLDAANIQQPVSDADIQAYYDQHQDQFTQPQRVRYSIIQTKTENEAKAVLDALNNGGDFAELAKEKSAD
IISARNGGDLGWLEDSTTPQELKDAGLKDKGQLSGVIKSSVGFLVVRLDDVQPAKVKTLAEVRDDIAAKVKHEKALDAYY
ALQQKVSDAASNDTESLAGAEQAAGVKAKETGWFSQQNLPEELNFKPVADAIFSGSLVGENGTPGSNSDIITVDGDRAFV
LRVSEHKAEAIKPLSEVKDQVKALVQHDKAEQQAKLEAEKLLVELKAGKGVDAMRAAGLQFGEQKTLSRSGQDPVSLAAF
ALGLPEKDKPSYGMATNTQGNVVLLALDEVKAGTMPEAQKQALVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=623, Percent_Identity=88.4430176565008, Blast_Score=1130, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 69785; Mature: 69785

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVYKSPTAECCYTMMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEE
NGQEISRGQFENAFNSERNRMQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RDLKLGISDEQVKQAIFATPAFQVDGKFDNSRYNAILNQMGMSADQYAQALRNQLTTQQL
HHHCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
INGIAGTDFMLKGETDELAALVSQQRVVREATIDVNAKAEKQQVSDAEITSYYDQHKNNF
HHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHCCCC
VTPEQFRVSYIMLDAANIQQPVSDADIQAYYDQHQDQFTQPQRVRYSIIQTKTENEAKAV
CCHHHHEEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
LDALNNGGDFAELAKEKSADIISARNGGDLGWLEDSTTPQELKDAGLKDKGQLSGVIKSS
HHHHCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHC
VGFLVVRLDDVQPAKVKTLAEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTESLAGA
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCH
EQAAGVKAKETGWFSQQNLPEELNFKPVADAIFSGSLVGENGTPGSNSDIITVDGDRAFV
HHHCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHCCCEECCCCCCCCCCCEEEECCCEEEE
LRVSEHKAEAIKPLSEVKDQVKALVQHDKAEQQAKLEAEKLLVELKAGKGVDAMRAAGLQ
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
FGEQKTLSRSGQDPVSLAAFALGLPEKDKPSYGMATNTQGNVVLLALDEVKAGTMPEAQK
CCCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
QALVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECHHHCCC
>Mature Secondary Structure
MREVYKSPTAECCYTMMDSLRTAANSLVLKIIFGIIIVSFILTGVSGYLIGGGNNYAAKV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEE
NGQEISRGQFENAFNSERNRMQQQLGDQYSELAANEGYMKTLRQQVLNRLIDEALLDQYS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
RDLKLGISDEQVKQAIFATPAFQVDGKFDNSRYNAILNQMGMSADQYAQALRNQLTTQQL
HHHCCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
INGIAGTDFMLKGETDELAALVSQQRVVREATIDVNAKAEKQQVSDAEITSYYDQHKNNF
HHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHCCCC
VTPEQFRVSYIMLDAANIQQPVSDADIQAYYDQHQDQFTQPQRVRYSIIQTKTENEAKAV
CCHHHHEEEEEEEEHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHH
LDALNNGGDFAELAKEKSADIISARNGGDLGWLEDSTTPQELKDAGLKDKGQLSGVIKSS
HHHHCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHC
VGFLVVRLDDVQPAKVKTLAEVRDDIAAKVKHEKALDAYYALQQKVSDAASNDTESLAGA
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCH
EQAAGVKAKETGWFSQQNLPEELNFKPVADAIFSGSLVGENGTPGSNSDIITVDGDRAFV
HHHCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHCCCEECCCCCCCCCCCEEEECCCEEEE
LRVSEHKAEAIKPLSEVKDQVKALVQHDKAEQQAKLEAEKLLVELKAGKGVDAMRAAGLQ
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
FGEQKTLSRSGQDPVSLAAFALGLPEKDKPSYGMATNTQGNVVLLALDEVKAGTMPEAQK
CCCHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHH
QALVQGITQNNAQIVFEALMSNLRKEAKIKIGDALEQQ
HHHHHHHHCCCHHHHHHHHHHHHHHHHEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]