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The map label for this gene is cusC [H]

Identifier: 218549854

GI number: 218549854

Start: 2602260

End: 2603648

Strand: Reverse

Name: cusC [H]

Synonym: EFER_2538

Alternate gene names: 218549854

Gene position: 2603648-2602260 (Counterclockwise)

Preceding gene: 218549859

Following gene: 218549853

Centisome position: 56.74

GC content: 51.76

Gene sequence:

>1389_bases
GTGCCTATGTCTCCTTGTAAACTTCTGCCATTTTGTGTGGCCCTTGCGCTAACCGGTTGTTCACTGGCACCGGATTATCA
GCGTCCGGCAATGCCCGTGCCGCAGCAGTTCTCACTCAGCCAGAACGGCCAGGTTAACGCGGTAGATAACTACCAGAACG
CGGGCTGGCGCACCTTTTTTGTTGATAATCAGGTGAAGACGCTGATTAGCGAGGCGCTGGTGAATAACCGGGATTTGCGC
ATGGCGACGCTGAAAGTGCAGGAGGCACGGACGCAATATCGTCTGACCGATGCCGACCGCTACCCGCAGCTCAATGGCGA
GGGTAGCGGCAGCTGGAGCGGCAATCTTAAAGGCGATTCAGCCACGACGCGGGAGTTCTCGACTGGCCTTAACGCCAGCT
TTGATTTCGATTTTTTCGGTCGCTTAAAGAACATGAGCGAAGCCGAGCGACAAAATTATTTAGCCACTGAGGAAGCTCAG
CGCGCGGTGCATATTCTGCTGGTTTCTAATGTCGCGCAAAGCTATTTCAATCAGCAACTGGCTTATGCGCAATTACAAAT
AGCCGAAGAAACGCTGCGTAATTATCAGCAGTCATATGCGTTTGTCGAAAAACAACTTTTGACTGGTAGCAGCAATGTTC
TGGCGCTGGAACAGGCTCGCGGGGTGATAGAAAGTACCCGCAGTGATATCGCTAAACGTCAGGGGGAACTGGCGCAGGCG
AATAATGCATTGCAACTGTTATTGGGAAGCTACGGCAAGCTGCCGCAAGCGCAGACAGTAAACAGCGACAGCCTGCAAAG
CGTTAAATTACCGGCGGGCTTGTCGTCGCAAATCTTGTTGCAGCGCCCGGATATTATGGAAGCTGAACACGCGTTAATGG
CGGCTAATGCCAATATTGGTGCTGCGCGTGCGGCATTTTTCCCGTCTATCAGCCTGACCAGCGGAATATCAACCGCCAGC
AGCGATCTGTCATCATTATTTAACGCCAGCAGCGGGATGTGGAATTTTATTCCCAAAATTGAGATCCCCATTTTTAATGC
CGGACGCAACCAGGCCAATCTGGATATCGCCGAAATTCGCCAGCAGCAGTCGGTGGTGAATTATGAACAGAAAATCCAGA
ACGCCTTTAAAGAAGTGGCAGATGCGCTTGCATTACGTCAAAGCCTGAACGATCAAATCAGCGCCCAGCAGCGTTATCTG
GCGTCGCTGCAAATTACGTTGCAACGGGCGCGGGCATTATATCAGCACGGCGCGGTAAGTTATCTGGAAGTGCTGGATGC
CGAGCGTTCCTTATTTGCAACCCGACAAACTTTACTCGACCTGAATTATGCCCGTCAGGTTAACGAAGTTTCCTTATATA
CCGCCCTGGGTGGCGGTTGGCAGCAATAA

Upstream 100 bases:

>100_bases
CAATCGCTTATTGGCAAAATGACAATTTTGTCATTTTCCTGTCACCGGAAAATCAGAGCCTGGCGTGTAAAGTTGGCGGC
ATAAAATCACCAGAAATTAT

Downstream 100 bases:

>100_bases
ATTTTAACTCCAGGAGAGAATAATGAAAAAAGCACTGCAAGTCGTAATGTTCAGTCTGTTTACTGTTATTGGCTTTAATG
CCCAGGCTAACGAACATCAT

Product: copper/silver efflux system outer membrane protein CusC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MPMSPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGQVNAVDNYQNAGWRTFFVDNQVKTLISEALVNNRDLR
MATLKVQEARTQYRLTDADRYPQLNGEGSGSWSGNLKGDSATTREFSTGLNASFDFDFFGRLKNMSEAERQNYLATEEAQ
RAVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQA
NNALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGISTAS
SDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYL
ASLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEVSLYTALGGGWQQ

Sequences:

>Translated_462_residues
MPMSPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGQVNAVDNYQNAGWRTFFVDNQVKTLISEALVNNRDLR
MATLKVQEARTQYRLTDADRYPQLNGEGSGSWSGNLKGDSATTREFSTGLNASFDFDFFGRLKNMSEAERQNYLATEEAQ
RAVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQA
NNALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGISTAS
SDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYL
ASLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEVSLYTALGGGWQQ
>Mature_461_residues
PMSPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGQVNAVDNYQNAGWRTFFVDNQVKTLISEALVNNRDLRM
ATLKVQEARTQYRLTDADRYPQLNGEGSGSWSGNLKGDSATTREFSTGLNASFDFDFFGRLKNMSEAERQNYLATEEAQR
AVHILLVSNVAQSYFNQQLAYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQAN
NALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIGAARAAFFPSISLTSGISTASS
DLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIRQQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLA
SLQITLQRARALYQHGAVSYLEVLDAERSLFATRQTLLDLNYARQVNEVSLYTALGGGWQQ

Specific function: Part of a cation efflux system that mediates resistance to copper and silver [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=457, Percent_Identity=98.4682713347921, Blast_Score=914, Evalue=0.0,
Organism=Escherichia coli, GI2367348, Length=462, Percent_Identity=26.6233766233766, Blast_Score=148, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51021; Mature: 50890

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGQVNAVDNYQNAGWRTFF
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEE
VDNQVKTLISEALVNNRDLRMATLKVQEARTQYRLTDADRYPQLNGEGSGSWSGNLKGDS
ECHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCC
ATTREFSTGLNASFDFDFFGRLKNMSEAERQNYLATEEAQRAVHILLVSNVAQSYFNQQL
CCHHHHHCCCCCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHH
NNALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIG
CHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCEECCCCHHHHHHHHHCCCCCCC
AARAAFFPSISLTSGISTASSDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIR
HHHHHHCCCCHHHCCCCHHHHHHHHHHHCCCCCEECCCCEEEEEEECCCCCCCCCHHHHH
QQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLASLQITLQRARALYQHGAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLEVLDAERSLFATRQTLLDLNYARQVNEVSLYTALGGGWQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC
>Mature Secondary Structure 
PMSPCKLLPFCVALALTGCSLAPDYQRPAMPVPQQFSLSQNGQVNAVDNYQNAGWRTFF
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEE
VDNQVKTLISEALVNNRDLRMATLKVQEARTQYRLTDADRYPQLNGEGSGSWSGNLKGDS
ECHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCCC
ATTREFSTGLNASFDFDFFGRLKNMSEAERQNYLATEEAQRAVHILLVSNVAQSYFNQQL
CCHHHHHCCCCCCCCHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYAQLQIAEETLRNYQQSYAFVEKQLLTGSSNVLALEQARGVIESTRSDIAKRQGELAQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHHH
NNALQLLLGSYGKLPQAQTVNSDSLQSVKLPAGLSSQILLQRPDIMEAEHALMAANANIG
CHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCEECCCCHHHHHHHHHCCCCCCC
AARAAFFPSISLTSGISTASSDLSSLFNASSGMWNFIPKIEIPIFNAGRNQANLDIAEIR
HHHHHHCCCCHHHCCCCHHHHHHHHHHHCCCCCEECCCCEEEEEEECCCCCCCCCHHHHH
QQQSVVNYEQKIQNAFKEVADALALRQSLNDQISAQQRYLASLQITLQRARALYQHGAVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
YLEVLDAERSLFATRQTLLDLNYARQVNEVSLYTALGGGWQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]