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The map label for this gene is mngA [H]

Identifier: 218549696

GI number: 218549696

Start: 2429838

End: 2431766

Strand: Reverse

Name: mngA [H]

Synonym: EFER_2373

Alternate gene names: 218549696

Gene position: 2431766-2429838 (Counterclockwise)

Preceding gene: 218549706

Following gene: 218549695

Centisome position: 52.99

GC content: 54.28

Gene sequence:

>1929_bases
GTGAGGATCATGATGAACCTGACGACTCTGACCCACCGCGATGCGCTGTGCCTGAATGCGCGCTTTACCAGCCGTGAAGA
GGCCATCCACGCGTTGACTCAACGTCTTGCTGCTCTGGGGAAAATTTCCAGTACTGAGCAATTTCTGGAAGAAGTGCATC
ACCGTGAAAGTCTTGGCCCGACGGCCTTAGGTGAAGGGCTGGCTGTGCCGCATGGTAAAACTGCTGCGGTAAAAGAAGCA
GCGTTTGCGGTCGCGACACTGAGTGAGCCGCTTCAGTGGGAAGGCGTTGATGGCCCGGAAGCGGTTGATTTAGTGGTGTT
GCTGGCTATTCCTCCCAATGAAGCAGGTACAACGCATATGCAATTGCTGACAGCGCTGACCACGCGCCTGGCGGATGATG
AGATTCGGGCGAGAATTCAGTCAGCAACGACGCCAGATGAGTTGCTTTCGGCGCTTGATGATAAATGGTATGCACAACCT
GCAGTGAATTTCAGCAATGCGCCAACAATTGTTTGTGTGACGGCCTGTCCGGCAGGGATAGCCCACACCTATATGGCTGC
GGAATATCTGGAGAAAGCAGGGCGAAAGTTGGGCGTGAATGTCTTTGTTGAAAAGCAGGGAGCTAACGGTATTGAAGGGC
GTTTAACGGCGGATCAACTCAATAGTGCAACTGCGTGTATTTTTGCGGCTGAAGTCGCCATCAAGGAGAGTGAGCGTTTT
AACGGCATTCCTGCGCTTTCTGTGCCTGTTGCCGAGCCGATTCGCCATGCAGAAGCATTGATCCAACAAGCGCTTACCCT
CAAGCGTAGTGATGAGACGCGTACTGTACAGCAAGATACGCAACCGGTGAAAAGTGTCAAAACTGAGCTGAAACAGGCGC
TGTTAAGCGGGATCTCTTTCGCCGTGCCGTTGATTGTCGCGGGGGGCACGGTGCTGGCGGTTGCGGTATTACTGTCGCAA
ATCTTCGGGCTACAAGATTTGTTTAATGAAGAAAACTCCTGGCTGTGGATGTACCGCAAGCTGGGCGGCGGGATGCTCGG
GATTTTGATGGTGCCGGTGCTGGCAGCCTATACCGCCTATTCGCTGGCAGATAAACCGGCGTTAGCGCCGGGCTTTGCGG
CTGGACTGGCCGCCAACATGATCGGTTCCGGGTTTCTCGGCGCGGTCGTTGGCGGATTGATAGCCGGTTACCTGATGCGC
TGGGTGAAAAATCACTTACGTCTTAGCAGTAAATTCAATGGCTTCCTGACTTTCTATCTCTACCCGGTGCTCGGTACATT
GGGAGCGGGCAGTCTGATGCTGTTTGTGGTGGGGGAACCTGTCGCCTGGATCAATAACTCGCTTACCGCCTGGCTGAACG
GTCTGTCAGGAAGTAATGCGCTGTTGCTTGGCGCCATTCTCGGTTTTATGTGTTCCTTTGACCTTGGTGGGCCAGTGAAC
AAAGCCGCTTATGCATTCTGCCTCGGCGCAATGGCGAACGGCGTTTACGGCCCCTATGCCATTTTCGCCTCCGTCAAAAT
GGTTTCGGCATTTACCGTAACGGCTTCCACGATGCTCGCGCCGCGCCTGTTTAAAGAATTTGAAATTGAAACCGGGAAAT
CAACCTGGCTATTGGGGCTGGCGGGGATTACGGAAGGGGCGATCCCGATGGCGATTGAAGATCCATTGCGCGTCATTGGC
TCTTTTGTGCTGGGCTCTATGGTGACGGGCGCTATCGTTGGCGCGATGAATATTGGCCTTTCCACACCGGGGGCCGGAAT
ATTCTCCCTCTTTTTACTTCATGATAACGGTGCTGGTGGTGTGATGGCTGCTCTGGGCTGGTTTGGCGCGGCGCTGGTGG
GGAGCGCAATCTCTACCGCAATTCTCCTGATCTGGCGGCGTCACGCGGTTAAGCATGGCAACTATCTGATTGACGGCGTA
ACGCCATAA

Upstream 100 bases:

>100_bases
AATAATACAAATATAATACAAATAATCTCAATCAAGTGAAATTGATCACATAATAGTATTTGTTTGTCGGGCACACTGGC
GCGACTATAAAAACGATCAA

Downstream 100 bases:

>100_bases
ACAAAAACAGGAAACGACGATGAAAGCTGTATCTCGCGTTCACATCACCCCGCATATGCACTGGGATCGGGAGTGGTATT
TTACTACCGAAGAGTCACGC

Product: PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC

Products: NA

Alternate protein names: Putative PTS system EIIABC component; Phosphotransferase enzyme IIA component; PTS system EIIA component; Phosphotransferase enzyme IIB component; PTS system EIIB component; Permease IIC component; PTS system EIIC component [H]

Number of amino acids: Translated: 642; Mature: 642

Protein sequence:

>642_residues
MRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISSTEQFLEEVHHRESLGPTALGEGLAVPHGKTAAVKEA
AFAVATLSEPLQWEGVDGPEAVDLVVLLAIPPNEAGTTHMQLLTALTTRLADDEIRARIQSATTPDELLSALDDKWYAQP
AVNFSNAPTIVCVTACPAGIAHTYMAAEYLEKAGRKLGVNVFVEKQGANGIEGRLTADQLNSATACIFAAEVAIKESERF
NGIPALSVPVAEPIRHAEALIQQALTLKRSDETRTVQQDTQPVKSVKTELKQALLSGISFAVPLIVAGGTVLAVAVLLSQ
IFGLQDLFNEENSWLWMYRKLGGGMLGILMVPVLAAYTAYSLADKPALAPGFAAGLAANMIGSGFLGAVVGGLIAGYLMR
WVKNHLRLSSKFNGFLTFYLYPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLGAILGFMCSFDLGGPVN
KAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLFKEFEIETGKSTWLLGLAGITEGAIPMAIEDPLRVIG
SFVLGSMVTGAIVGAMNIGLSTPGAGIFSLFLLHDNGAGGVMAALGWFGAALVGSAISTAILLIWRRHAVKHGNYLIDGV
TP

Sequences:

>Translated_642_residues
MRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISSTEQFLEEVHHRESLGPTALGEGLAVPHGKTAAVKEA
AFAVATLSEPLQWEGVDGPEAVDLVVLLAIPPNEAGTTHMQLLTALTTRLADDEIRARIQSATTPDELLSALDDKWYAQP
AVNFSNAPTIVCVTACPAGIAHTYMAAEYLEKAGRKLGVNVFVEKQGANGIEGRLTADQLNSATACIFAAEVAIKESERF
NGIPALSVPVAEPIRHAEALIQQALTLKRSDETRTVQQDTQPVKSVKTELKQALLSGISFAVPLIVAGGTVLAVAVLLSQ
IFGLQDLFNEENSWLWMYRKLGGGMLGILMVPVLAAYTAYSLADKPALAPGFAAGLAANMIGSGFLGAVVGGLIAGYLMR
WVKNHLRLSSKFNGFLTFYLYPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLGAILGFMCSFDLGGPVN
KAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLFKEFEIETGKSTWLLGLAGITEGAIPMAIEDPLRVIG
SFVLGSMVTGAIVGAMNIGLSTPGAGIFSLFLLHDNGAGGVMAALGWFGAALVGSAISTAILLIWRRHAVKHGNYLIDGV
TP
>Mature_642_residues
MRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISSTEQFLEEVHHRESLGPTALGEGLAVPHGKTAAVKEA
AFAVATLSEPLQWEGVDGPEAVDLVVLLAIPPNEAGTTHMQLLTALTTRLADDEIRARIQSATTPDELLSALDDKWYAQP
AVNFSNAPTIVCVTACPAGIAHTYMAAEYLEKAGRKLGVNVFVEKQGANGIEGRLTADQLNSATACIFAAEVAIKESERF
NGIPALSVPVAEPIRHAEALIQQALTLKRSDETRTVQQDTQPVKSVKTELKQALLSGISFAVPLIVAGGTVLAVAVLLSQ
IFGLQDLFNEENSWLWMYRKLGGGMLGILMVPVLAAYTAYSLADKPALAPGFAAGLAANMIGSGFLGAVVGGLIAGYLMR
WVKNHLRLSSKFNGFLTFYLYPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLGAILGFMCSFDLGGPVN
KAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLFKEFEIETGKSTWLLGLAGITEGAIPMAIEDPLRVIG
SFVLGSMVTGAIVGAMNIGLSTPGAGIFSLFLLHDNGAGGVMAALGWFGAALVGSAISTAILLIWRRHAVKHGNYLIDGV
TP

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane [H]

COG id: COG1299

COG function: function code G; Phosphotransferase system, fructose-specific IIC component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1786951, Length=642, Percent_Identity=97.5077881619938, Blast_Score=1244, Evalue=0.0,
Organism=Escherichia coli, GI1788492, Length=473, Percent_Identity=35.7293868921776, Blast_Score=269, Evalue=4e-73,
Organism=Escherichia coli, GI87082348, Length=480, Percent_Identity=32.9166666666667, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1790386, Length=289, Percent_Identity=39.1003460207612, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1788729, Length=393, Percent_Identity=26.972010178117, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1790387, Length=94, Percent_Identity=43.6170212765958, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1788730, Length=103, Percent_Identity=34.9514563106796, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI48994992, Length=151, Percent_Identity=24.5033112582781, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788726, Length=136, Percent_Identity=27.2058823529412, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789597, Length=151, Percent_Identity=27.8145695364238, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 67758; Mature: 67758

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISSTEQFLEEVHHRESLGP
CEEEEEEHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
TALGEGLAVPHGKTAAVKEAAFAVATLSEPLQWEGVDGPEAVDLVVLLAIPPNEAGTTHM
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEEEECCCCCCHHHH
QLLTALTTRLADDEIRARIQSATTPDELLSALDDKWYAQPAVNFSNAPTIVCVTACPAGI
HHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCHHCCCCCCCCCCCCCEEEEECCCCHH
AHTYMAAEYLEKAGRKLGVNVFVEKQGANGIEGRLTADQLNSATACIFAAEVAIKESERF
HHHHHHHHHHHHCCCEECCEEEEEECCCCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHC
NGIPALSVPVAEPIRHAEALIQQALTLKRSDETRTVQQDTQPVKSVKTELKQALLSGISF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVPLIVAGGTVLAVAVLLSQIFGLQDLFNEENSWLWMYRKLGGGMLGILMVPVLAAYTAY
HHHHHHCCHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHH
SLADKPALAPGFAAGLAANMIGSGFLGAVVGGLIAGYLMRWVKNHLRLSSKFNGFLTFYL
HHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLGAILGFMCSFDLGGPVN
HHHHHHCCCCCEEEEEECCCHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCH
KAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLFKEFEIETGKSTWLLGL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
AGITEGAIPMAIEDPLRVIGSFVLGSMVTGAIVGAMNIGLSTPGAGIFSLFLLHDNGAGG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEEECCCCCH
VMAALGWFGAALVGSAISTAILLIWRRHAVKHGNYLIDGVTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC
>Mature Secondary Structure
MRIMMNLTTLTHRDALCLNARFTSREEAIHALTQRLAALGKISSTEQFLEEVHHRESLGP
CEEEEEEHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
TALGEGLAVPHGKTAAVKEAAFAVATLSEPLQWEGVDGPEAVDLVVLLAIPPNEAGTTHM
HHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEEEEECCCCCCHHHH
QLLTALTTRLADDEIRARIQSATTPDELLSALDDKWYAQPAVNFSNAPTIVCVTACPAGI
HHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCHHCCCCCCCCCCCCCEEEEECCCCHH
AHTYMAAEYLEKAGRKLGVNVFVEKQGANGIEGRLTADQLNSATACIFAAEVAIKESERF
HHHHHHHHHHHHCCCEECCEEEEEECCCCCCCCCEEHHHHCCHHHHHHHHHHHHHHHHHC
NGIPALSVPVAEPIRHAEALIQQALTLKRSDETRTVQQDTQPVKSVKTELKQALLSGISF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVPLIVAGGTVLAVAVLLSQIFGLQDLFNEENSWLWMYRKLGGGMLGILMVPVLAAYTAY
HHHHHHCCHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHH
SLADKPALAPGFAAGLAANMIGSGFLGAVVGGLIAGYLMRWVKNHLRLSSKFNGFLTFYL
HHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YPVLGTLGAGSLMLFVVGEPVAWINNSLTAWLNGLSGSNALLLGAILGFMCSFDLGGPVN
HHHHHHCCCCCEEEEEECCCHHHHCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCH
KAAYAFCLGAMANGVYGPYAIFASVKMVSAFTVTASTMLAPRLFKEFEIETGKSTWLLGL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEE
AGITEGAIPMAIEDPLRVIGSFVLGSMVTGAIVGAMNIGLSTPGAGIFSLFLLHDNGAGG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEEEEEECCCCCH
VMAALGWFGAALVGSAISTAILLIWRRHAVKHGNYLIDGVTP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9063979; 9278503; 8905232 [H]