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The map label for this gene is lysP [H]

Identifier: 218549569

GI number: 218549569

Start: 2299696

End: 2301165

Strand: Reverse

Name: lysP [H]

Synonym: EFER_2241

Alternate gene names: 218549569

Gene position: 2301165-2299696 (Counterclockwise)

Preceding gene: 218549570

Following gene: 218549568

Centisome position: 50.15

GC content: 52.45

Gene sequence:

>1470_bases
ATGGTTTCCGAAACTAAAACTACAGAAGCGCCCGGTTTACGCCGTGAGTTAAAGGCGCGCCACCTGACGATGATTGCCAT
TGGCGGTTCCATCGGTACAGGTCTTTTTGTTGCTTCTGGTGCAACGATTTCTCAGGCGGGCCCAGGTGGCGCGCTGCTCT
CATATATTCTGATAGGTCTGATGGTTTACTTCCTGATGACCAGTCTCGGTGAACTGGCTGCATATATGCCGGTTTCCGGT
TCGTTTGCCACTTACGGTCAGAACTATGTTGAAGAAGGCTTTGGCTTCGCGTTGGGCTGGAACTACTGGTACAACTGGGC
GGTAACTATCGCTGTTGACCTGGTAGCTGCGCAGCTGGTCATGAGCTGGTGGTTCCCGGATACGCCCGGTTGGATCTGGA
GTGCCTTGTTCCTTGGCGTTATCTTCCTGCTGAACTACATCTCTGTTCGTGGCTTTGGTGAAGCTGAATACTGGTTCTCA
CTTATCAAAGTTGCCACTGTGGTTATCTTTATCATCGTCGGTGTAATGATGATTATTGGTATCTTCAAAGGCGCACAGCC
GGCGGGCTGGAGCAACTGGACGATAGGCGAGGCACCGTTTGCCGGTGGTTTTGCGGCGATGATCGGTGTGGCGATGATTG
TCGGCTTCTCCTTCCAGGGAACAGAGTTGATCGGTATTGCAGCTGGCGAATCTGAAGATCCGGCGAAAAACATTCCGCGC
GCGGTGCGTCAGGTGTTCTGGCGAATCCTGCTGTTCTATGTGTTCGCGATTCTGATCATCAGCCTGATCATTCCTTACAC
TGATCCGAGCCTGCTGCGTAACGATGTGAAAGATATTAGCGTTAGCCCGTTCACCCTGGTGTTCCAGCACGCGGGGCTGC
TCTCTGCGGCGGCAGTGATGAACGCGGTCATTCTGACGGCAGTACTGTCAGCGGGTAACTCCGGGATGTATGCATCTACC
CGTATGCTGTATACCCTGGCCTGTGACGGTAAAGCGCCGCGTATTTTCGCTAAACTGTCGCGTGGTGGCGTGCCGCGTAA
CGCTCTGTATGCGACAACGGTGATCGCGGGTCTGTGCTTTCTGACATCTATGTTCGGTAACCAGACAGTTTACTTATGGC
TGCTGAACACCTCCGGGATGACAGGTTTCATCGCCTGGCTGGGGATTGCAATTAGCCATTATCGCTTCCGTCGCGGTTAT
GTATTGCAGGGTCATGATATTAACGATCTGCCATACCGTTCTGGTTTCTTCCCGCTGGGGCCGATCTTCGCATTTGTACT
GTGCCTGATCATCACTCTGGGTCAGAACTACGAAGCGTTCCTGAAAGACACCATCGACTGGGGCGGCGTAGCGGCGACGT
ATATCGGTATTCCGCTGTTCCTGGCTATCTGGTTTGGTTACAAGTTGATTAAAGGAACACACTTTGTGCGTTACAGCGAA
ATGAAGTTCCCGCAGAACGACAACAAATAA

Upstream 100 bases:

>100_bases
CAGTCATGAAGGTCTCTTATAACTGCGTATTTGTACCGGAAGGAAAGCATTTCCTCTGCTACAATCGCGCCTCATTTTTT
GGATGGATAGCATTTTTAGT

Downstream 100 bases:

>100_bases
GTCATCCCCCTTCCTAACGAAGCCCTCTCAACCGAGAGGGCTTTTTCTTTTCCTTAATAATCATGCTGATATAAATTTAA
CAATTAGATTGATAATTGTT

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVATVVIFIIVGVMMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLAIWFGYKLIKGTHFVRYSE
MKFPQNDNK

Sequences:

>Translated_489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVATVVIFIIVGVMMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLAIWFGYKLIKGTHFVRYSE
MKFPQNDNK
>Mature_489_residues
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFS
LIKVATVVIFIIVGVMMIIGIFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGHDINDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLAIWFGYKLIKGTHFVRYSE
MKFPQNDNK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=369, Percent_Identity=24.390243902439, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788480, Length=489, Percent_Identity=98.3640081799591, Blast_Score=972, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=40.1826484018265, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI48994972, Length=466, Percent_Identity=37.9828326180258, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1786789, Length=418, Percent_Identity=37.5598086124402, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1786302, Length=408, Percent_Identity=35.7843137254902, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI1790653, Length=422, Percent_Identity=35.0710900473934, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1789017, Length=392, Percent_Identity=34.1836734693878, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI87081915, Length=395, Percent_Identity=34.9367088607595, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786602, Length=406, Percent_Identity=37.192118226601, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI87081869, Length=395, Percent_Identity=24.0506329113924, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082023, Length=335, Percent_Identity=23.8805970149254, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082250, Length=234, Percent_Identity=28.2051282051282, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=389, Percent_Identity=24.9357326478149, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=474, Percent_Identity=36.4978902953587, Blast_Score=323, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6324990, Length=487, Percent_Identity=34.7022587268994, Blast_Score=306, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6324061, Length=482, Percent_Identity=34.4398340248963, Blast_Score=304, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=37.0526315789474, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6324059, Length=476, Percent_Identity=35.7142857142857, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6324924, Length=483, Percent_Identity=33.5403726708075, Blast_Score=274, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=480, Percent_Identity=30.2083333333333, Blast_Score=260, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6324553, Length=429, Percent_Identity=35.4312354312354, Blast_Score=259, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6319824, Length=472, Percent_Identity=29.2372881355932, Blast_Score=239, Evalue=9e-64,
Organism=Saccharomyces cerevisiae, GI6322967, Length=470, Percent_Identity=31.7021276595745, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6320717, Length=482, Percent_Identity=28.0082987551867, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6321053, Length=464, Percent_Identity=29.3103448275862, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319543, Length=474, Percent_Identity=29.3248945147679, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6319542, Length=472, Percent_Identity=27.7542372881356, Blast_Score=219, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6324981, Length=480, Percent_Identity=32.5, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6320251, Length=480, Percent_Identity=26.0416666666667, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=493, Percent_Identity=27.9918864097363, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320364, Length=555, Percent_Identity=25.9459459459459, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24666159, Length=358, Percent_Identity=24.0223463687151, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366235, Length=396, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007820, Length=396, Percent_Identity=23.4848484848485, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221512776, Length=358, Percent_Identity=24.0223463687151, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53476; Mature: 53476

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGL
CCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAYMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLV
HHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHH
MSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFSLIKVATVVIFIIVGVMMIIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCF
HHHHHHHHHHCCCCCCEEHHEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGHDINDLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHH
PIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLAIWFGYKLIKGTHFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
MKFPQNDNK
CCCCCCCCC
>Mature Secondary Structure
MVSETKTTEAPGLRRELKARHLTMIAIGGSIGTGLFVASGATISQAGPGGALLSYILIGL
CCCCCCCCCCCCHHHHHHHHHEEEEEECCCCCCCEEEECCCEECCCCCCHHHHHHHHHHH
MVYFLMTSLGELAAYMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLV
HHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHH
MSWWFPDTPGWIWSALFLGVIFLLNYISVRGFGEAEYWFSLIKVATVVIFIIVGVMMIIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGAQPAGWSNWTIGEAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESEDPAKNIPR
HHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPSLLRNDVKDISVSPFTLVFQHAGLLSAAAVM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCF
HHHHHHHHHHCCCCCCEEHHEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGHDINDLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHH
PIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLAIWFGYKLIKGTHFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
MKFPQNDNK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]