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The map label for this gene is cirA [H]

Identifier: 218549568

GI number: 218549568

Start: 2297434

End: 2299413

Strand: Reverse

Name: cirA [H]

Synonym: EFER_2240

Alternate gene names: 218549568

Gene position: 2299413-2297434 (Counterclockwise)

Preceding gene: 218549569

Following gene: 218549566

Centisome position: 50.11

GC content: 51.06

Gene sequence:

>1980_bases
ATGTTTAGGTTGAACCCTTTCGTACGGGTCGGGCTATGTTTGTCCGCAATTTCTTGTGCATGGCCTGTGTTAGCGGTTGA
TAGCGATGGCGAAACGATGGTTGTCACCGCCTCTTCCATTGAACAAAACCTCAAAGATGCACCTGCGAGTATTAGCGTTA
TTACTCAGGAAGATTTGCAGCGTAAACCTGTTCAGAATCTGAAAGATGTCCTCAAAGAAGTGCCAGGCGTACAACTGACG
AACGAAGGTGACAACCGCAAGGGTGTCAGTATTCGTGGTCTCGACAGCAGCTACACGCTGATTCTTGTCGATGGTAAACG
CGTTAACTCCCGCAATGCCGTCTTCCGCCATAATGATTTCGATCTGAACTGGATCCCGGTCGATTCCATCGAACGTATTG
AAGTGGTCCGTGGCCCGATGTCTTCGCTGTACGGTTCCGATGCACTTGGCGGTGTGGTGAATATCATCACTAAAAAAATC
GGCCAAAAATGGGCAGGCACAGTAACCGTCGATACCACCATTCAGGAACATCGCGATCGCGGTGATACCTATAACGGCCA
GTTCTTTACCAGCGGACCATTGATTGATGGCGTGCTGGGAATGAAAGCTTACGGCAGCCTGGCAAAACGTGAAAAGGATG
ATCCACAAAATTCAACCACCACCGATACCGGAGAAACACCACGTATTGAAGGATTCTCCAGCCGCGACGGCAATGTTGAA
TTTGCCTGGACACCGAATCAAAATCACGATTTTACTGCCGGATACGGTTTTGACCGTCAGGATCGTGATTCCGACTCGCT
GGACAAAAACCGCCTCGAACGCCAGAACTACTCTGTCAGCCATAATGGTCGCTGGGATTACGGTACCAGCGAACTGAAAT
ATTACGGCGAGAAAGTTGAGAACAAAAACCCTGGTAACAGCAGTCCGATCACTTCCGAAAGTAATACCGTCGATGGCAAA
TACACGTTGCCGCTGACGGCGATTAATCAGTTTGTCACGTTTGGCGGTGAATGGCGTCACGACAAACTTAGCGATGCGGT
AAACCTGACTGGTGGTACCAGCACCAAAACATCTGCCAGCCAGTACGCGCTGTTTGTTGAAGATGAATGGCGGATCTTCG
AACCGTTGTCACTGACTACCGGCGTACGTATGGACGATCATGAAACCTACGGTGAACACTGGAGTCCGCGTGCCTACCTG
GTTTATAACGCCACCGATACTGTAACGGTGAAAGGGGGCTGGGCGACGGCATTTAAAGCGCCTTCTCTGTTGCAACTTAG
CCCTGACTGGACGAGCAATTCCTGCCGTGGGGCATGTAAGATTGTGGGTAGCCCGGATCTGAAACCTGAAACCAGCGAAA
GCTGGGAGCTGGGGCTGTACTACCTGGGTGAAGAGGGCTGGCTGGAAGGGGTGGAATCCAGCGTGACCGTTTTCCGTAAC
GATGTGAAAGATCGTATCAGCATCAGCCGTACGTCTGACGTCAATGCTGCACCGGGCTACCAAAACTTTGTTGGTTTTAC
AGCGGACGGTGTGCCGGTATTCAGCTACTACAACGTTAACAAAGCACGTATTCAGGGCGTGGAAACCGAACTGAAAATTC
CGTTCAACGATGAATGGAAACTGTCACTCAACTACACCTACAACGATGGTCGTGATGTCAGCAACGGCGAAAATAAACCG
CTATCCGATCTGCCGTTCCATACTGCTAACGGTACGCTGGACTGGAAACCGCTGGCGCTGGAAGACTGGTCATTCTATGT
TTCTGGTCACTATACCGGGCAGAAACGAGCAGACAGCGCGACGGCTAAAACACCGGGCGGCTATACCATCTGGAATACCG
GCGCGGCCTGGCAGGTGACCAAAGACGTCAAACTGCGTGCGGGCGTGCTGAACCTGGGTGACAAGGATCTCAGTCGTGAC
GACTACAGCTATAACGAAGATGGACGTCGTTACTTTATGGCTGTGGATTATCGCTTCTGA

Upstream 100 bases:

>100_bases
ATTAAAAAGTCCACCGCGATGACGTTTTGCGCAGGGGGACATGCAGAAGATGTGAGCGATAACCCATTTTATTTTCGTAG
TTACCTCATGGAGATATGGA

Downstream 100 bases:

>100_bases
TGAGAAGATGCCCGGCGAACCGGGCAGACTTTACTTCAGTAAATGCTGCGCATGGAAGCGCAGATGATCCTCTATAAAAG
AGGCGATGAAGTAGTAACTG

Product: colicin I receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MFRLNPFVRVGLCLSAISCAWPVLAVDSDGETMVVTASSIEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLT
NEGDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKI
GQKWAGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVE
FAWTPNQNHDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGK
YTLPLTAINQFVTFGGEWRHDKLSDAVNLTGGTSTKTSASQYALFVEDEWRIFEPLSLTTGVRMDDHETYGEHWSPRAYL
VYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYLGEEGWLEGVESSVTVFRN
DVKDRISISRTSDVNAAPGYQNFVGFTADGVPVFSYYNVNKARIQGVETELKIPFNDEWKLSLNYTYNDGRDVSNGENKP
LSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRD
DYSYNEDGRRYFMAVDYRF

Sequences:

>Translated_659_residues
MFRLNPFVRVGLCLSAISCAWPVLAVDSDGETMVVTASSIEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLT
NEGDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKI
GQKWAGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVE
FAWTPNQNHDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGK
YTLPLTAINQFVTFGGEWRHDKLSDAVNLTGGTSTKTSASQYALFVEDEWRIFEPLSLTTGVRMDDHETYGEHWSPRAYL
VYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYLGEEGWLEGVESSVTVFRN
DVKDRISISRTSDVNAAPGYQNFVGFTADGVPVFSYYNVNKARIQGVETELKIPFNDEWKLSLNYTYNDGRDVSNGENKP
LSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRD
DYSYNEDGRRYFMAVDYRF
>Mature_659_residues
MFRLNPFVRVGLCLSAISCAWPVLAVDSDGETMVVTASSIEQNLKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLT
NEGDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDFDLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKI
GQKWAGTVTVDTTIQEHRDRGDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVE
FAWTPNQNHDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVENKNPGNSSPITSESNTVDGK
YTLPLTAINQFVTFGGEWRHDKLSDAVNLTGGTSTKTSASQYALFVEDEWRIFEPLSLTTGVRMDDHETYGEHWSPRAYL
VYNATDTVTVKGGWATAFKAPSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYLGEEGWLEGVESSVTVFRN
DVKDRISISRTSDVNAAPGYQNFVGFTADGVPVFSYYNVNKARIQGVETELKIPFNDEWKLSLNYTYNDGRDVSNGENKP
LSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSATAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRD
DYSYNEDGRRYFMAVDYRF

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=663, Percent_Identity=97.5867269984917, Blast_Score=1332, Evalue=0.0,
Organism=Escherichia coli, GI1786798, Length=745, Percent_Identity=32.6174496644295, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1790405, Length=695, Percent_Identity=26.0431654676259, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787723, Length=155, Percent_Identity=32.9032258064516, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 73401; Mature: 73401

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00430 TONB_DEPENDENT_REC_1 ; PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRLNPFVRVGLCLSAISCAWPVLAVDSDGETMVVTASSIEQNLKDAPASISVITQEDLQ
CCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEHHHHHHHHHCCCCEEEEEEHHHHH
RKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDF
CCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCEEEEEEECCEECCCCCEEEECCC
DLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWAGTVTVDTTIQEHRDR
CEEEEECCCCHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCHHHCCEEEEECCHHHHHCC
GDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVE
CCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
FAWTPNQNHDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVE
EEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
NKNPGNSSPITSESNTVDGKYTLPLTAINQFVTFGGEWRHDKLSDAVNLTGGTSTKTSAS
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCHHCCEEEECCCCCCCCCCC
QYALFVEDEWRIFEPLSLTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKA
EEEEEEECCCEEECCCCCCCCCEECCCCCCCCCCCCCEEEEECCCCEEEEECCEEEEECC
PSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYLGEEGWLEGVESSVTVFRN
CCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCHHHHCHHHHHHHHHH
DVKDRISISRTSDVNAAPGYQNFVGFTADGVPVFSYYNVNKARIQGVETELKIPFNDEWK
CHHHHEEEEECCCCCCCCCHHHCCCEECCCEEEEEEECCCHHHEECCCEEEECCCCCCEE
LSLNYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSA
EEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEECEEEEEEEEECCCCCCCCC
TAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF
CCCCCCCEEEECCCCEEEEECCCEEEECEECCCCCCCCCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MFRLNPFVRVGLCLSAISCAWPVLAVDSDGETMVVTASSIEQNLKDAPASISVITQEDLQ
CCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEEEHHHHHHHHHCCCCEEEEEEHHHHH
RKPVQNLKDVLKEVPGVQLTNEGDNRKGVSIRGLDSSYTLILVDGKRVNSRNAVFRHNDF
CCHHHHHHHHHHHCCCEEEECCCCCCCCCEEEECCCCEEEEEEECCEECCCCCEEEECCC
DLNWIPVDSIERIEVVRGPMSSLYGSDALGGVVNIITKKIGQKWAGTVTVDTTIQEHRDR
CEEEEECCCCHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCHHHCCEEEEECCHHHHHCC
GDTYNGQFFTSGPLIDGVLGMKAYGSLAKREKDDPQNSTTTDTGETPRIEGFSSRDGNVE
CCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEE
FAWTPNQNHDFTAGYGFDRQDRDSDSLDKNRLERQNYSVSHNGRWDYGTSELKYYGEKVE
EEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHC
NKNPGNSSPITSESNTVDGKYTLPLTAINQFVTFGGEWRHDKLSDAVNLTGGTSTKTSAS
CCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCCCCCCHHCCEEEECCCCCCCCCCC
QYALFVEDEWRIFEPLSLTTGVRMDDHETYGEHWSPRAYLVYNATDTVTVKGGWATAFKA
EEEEEEECCCEEECCCCCCCCCEECCCCCCCCCCCCCEEEEECCCCEEEEECCEEEEECC
PSLLQLSPDWTSNSCRGACKIVGSPDLKPETSESWELGLYYLGEEGWLEGVESSVTVFRN
CCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEEECCCHHHHCHHHHHHHHHH
DVKDRISISRTSDVNAAPGYQNFVGFTADGVPVFSYYNVNKARIQGVETELKIPFNDEWK
CHHHHEEEEECCCCCCCCCHHHCCCEECCCEEEEEEECCCHHHEECCCEEEECCCCCCEE
LSLNYTYNDGRDVSNGENKPLSDLPFHTANGTLDWKPLALEDWSFYVSGHYTGQKRADSA
EEEEEEECCCCCCCCCCCCCCCCCCEECCCCCCCCCCEEEECEEEEEEEEECCCCCCCCC
TAKTPGGYTIWNTGAAWQVTKDVKLRAGVLNLGDKDLSRDDYSYNEDGRRYFMAVDYRF
CCCCCCCEEEECCCCEEEEECCCEEEECEECCCCCCCCCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]